YRC Public Data Repository - Protein Structure Prediction

Protein:	MAM3
Organism:	Saccharomyces cerevisiae
Length:	706 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MAM3.

Description	E-value	Query Range	Subject Range
MAM3 - Protein required for normal mitochondrial morphology, has similarity to hemolysins MAM3_YEAST - Protein MAM3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MAM3 PE=1 SV=1	0.0	[1..706]	[1..706]
gi\|15809000, gi\|... - gi\|9280368\|gb\|AAF86373.1\| ancient conserved domain protein 2; mACDP2 [Mus musculus], gi\|15809000\|ref...	8.0E-95	[47..539]	[55..580]
gi\|6959526 - gi\|6959526\|gb\|AAF33142.1\|AF196836_1 putative hemolysin [Candida glabrata]	2.0E-93	[33..554]	[32..506]
gi\|9280370 - gi\|9280370\|gb\|AAF86374.1\| ancient conserved domain protein 2 [Homo sapiens]	5.0E-92	[53..539]	[1..520]
gi\|17134355, gi\|... - gi\|17232708\|ref\|NP_489256.1\| hypothetical protein alr5216 [Nostoc sp. PCC 7120], gi\|17134355\|dbj\|BAB... gi\|25302934 - pir\|\|AH2457 hypothetical protein alr5216 [imported] - Nostoc sp. (strain PCC 7120)	3.0E-89	[59..479]	[2..433]
gi\|221315397 - gi\|221315397\|ref\|ZP_03597202.1\| hypothetical protein BsubsN3_16922 [Bacillus subtilis subsp. subtili... YUGS_BACSU - UPF0053 protein yugS OS=Bacillus subtilis GN=yugS PE=3 SV=1 gi\|221320314 - gi\|221320314\|ref\|ZP_03601608.1\| hypothetical protein BsubsJ_16895 [Bacillus subtilis subsp. subtilis... gi\|16080182, gi\|... - gi\|2635626\|emb\|CAB15119.1\| yugS [Bacillus subtilis subsp. subtilis str. 168], gi\|16080182\|ref\|NP_391...	7.0E-89	[61..477]	[7..432]
gi\|25497441 - pir\|\|C97075 uncharacterized CBS domain-containing protein, YUGS B. subtilis ortholog [imported] - Cl... gi\|15024362, gi\|... - gi\|15894701\|ref\|NP_348050.1\| hypothetical protein CAC1422 [Clostridium acetobutylicum ATCC 824], gi\|...	2.0E-86	[63..475]	[5..426]
gi\|7429271 - pir\|\|B64706 hemolysin - Helicobacter pylori (strain 26695) gi\|2314662, gi\|1... - gi\|2314662\|gb\|AAD08525.1\| conserved hypothetical protein [Helicobacter pylori 26695], gi\|15646099\|re...	2.0E-86	[57..485]	[10..449]
gi\|7444893 - pir\|\|B71816 hypothetical protein jhp1383 - Helicobacter pylori (strain J99) gi\|15612448, gi\|... - gi\|4155992\|gb\|AAD06954.1\| putative [Helicobacter pylori J99], gi\|15612448\|ref\|NP_224101.1\| hypotheti...	3.0E-86	[57..485]	[2..441]

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Predicted Domain #1

Region A:
Residues: [1-195]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFLPLRSRS RSGAPHWVYI ILYHIFTIPK IYSLPLLSGS HVLNSRDVAD SGHSVGDEAS  60
   61 VTTYYIISII LVLLGGVFAG LTLGLMGQDE VYLKVISTSG SNSEKKLAKR VLDLISRGKH 120
  121 WVLVTLLLSN VITNETLPIV LDRCLGGGWQ AVVSSTILIV IFGEIIPQSV CVKYGLQVGA 180
  181 FFCPFVLVLM YLMYP

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	28.251812
Match:	PF01595
Description:	Domain of unknown function DUF21

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [196-521]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAYPIATLLD YMLGEDHGTM YKKSGLKTLV TLHRTMGVER LTKDEVTIIS AVLDLKAKRV  60
   61 EEIMTPIENV FTMSADTILD DKTVEKIFNS GFSRIPIFLP NEPNNFIGML LVRVLISYDP 120
  121 DDCLPISHFP LATLPETSPN TSCLNILNYF QEGKAHMCVV SKEPGSSHGA IGVLTLEDVI 180
  181 EELIGEEIVD ESDVFVDMHQ HIMRQQPGPL SKRHITSYLH HLYTSSHKEH KAADQADESS 240
  241 PLLSPSNSNH PSEHPQQDLN NKSWKQKSND GYDRSNAVLS PTPQVTEHGT IIPSNLASNP 300
  301 LNVNKSFVTI KKPANVPKII TTHTPH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.522879
Match:	1zfjA_
Description:	Inosine monophosphate dehydrogenase (IMPDH); Type II inosine monophosphate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [522-706]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSKEPSPAPH SNDKSLSAEE QQLLSDHAEL SRQAVLHTQR SGQPTQVTTS TKTTRNSPDS  60
   61 ISIPNSGANH GNENQNVTIS TSYQNTKNGI VESVITVKGV PKTIIGPAKD WDESKSEYGN 120
  121 ENINQENSNR SDDRESSSSN ASLFSSIKNK FKNENANNND RSNFTDSLSR TSNYDANGSS 180
  181 STIKR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits