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Protein Overview: ATG2

General Information:
Name(s) found: ATG2 / YNL242W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1592 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    pre-autophagosomal structure [IDALink to PubMed article]
    extrinsic to membrane [IDALink to PubMed article]
    Biological Process: autophagy [IMPLink to PubMed articleLink to PubMed article]
    peroxisome degradation [IDALink to PubMed article][IEPLink to PubMed article][IMPLink to PubMed article]
    protein targeting to vacuole [IEPLink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFWLPQNIQ KRLLLYVLQQ ISLFSNIDLS NLDVSIGSKS HFSFHDVNLS LDDLNIPNVQ  60
   61 INEGIVDELV LKLTVSGGVE IDGSGLRFIM TPLYSSGSQE LHSDFLVKSI QDLTNSMLQF 120
  121 SDPLTTYNRY KEDDISSSDS SSDLNSNIEA SKPAANGSYT LQNMRNKALN VALAKLKIAL 180
  181 KDVTIRFIVN DRDPSDNIVE VHLESIQLIT TDANLRHINI ENITISSIQK QAVPDSPVHP 240
  241 FNNDDLSQSV YLSKMEATSL YMSAMEEQSN EDPSEPQVTQ EEQENDKCKE SLMEINNLNI 300
  301 AFKGLSSVND LRMSNIVIDI QDVHLAIHKI VEIKNSTLKN IIDIIVTHLD ANESFSCQDS 360
  361 QSPSPDKQEP SALSSVDIKC IYLNLGQDIT VILKSFKLEQ KENNSLAFSL GSFYSNSSPL 420
  421 TISHKTKPLL TGEQTPQSIA LNMGDELDII ISHDGIAHFF KIFQFVSKCM SFYQNKSKGM 480
  481 MPQIASDTKR TVQLTSKAVK LSLKFPYFLL CFQVSPFIYD SNRELYIELV DVFKKLPSRC 540
  541 TKILTMSSIT ISNLQSPLQL GSYDDTLKEA LIYSSVHAII KEVIFNEEYS GIVQLVEDIS 600
  601 AFGKLFTDSK NSECTGKSKS KRGSFLQRSV RVLNSSRFVY KQSLSANFSL KIDSMKLKVS 660
  661 EIIGPQFGSV EALLSNNFFA ITDDSQIVYF TKNLKVERKT PSLLEPQEIM SVVLNKAVNE 720
  721 PVLYVHRRAN GKLKVIFNNI RIHYYARWLE ILKKNIGPDN ASSKDEPVSQ KLSKKQPTSG 780
  781 FPWELKCLDC SLILHPFRLK SVMVIVLDNL TTGGSSFIPQ AKLLSKANTL FLIDDYQNFK 840
  841 IQKDKNWPSL INFYAGQGFS AIGKIDTLNF LINKSDGALL LDCKIEQVGL SLCADSFQTF 900
  901 CQLCIDLKYP QTFPDEEKFR TQLKNPIDVF KDIDCDLFNS AFIRENNHQN DYDSVHLVDS 960
  961 FLDKTHEFNN GARSKLSSQG SYEMDSSSGT ATGGILLPHE SYLDSAQPKE EDTPPIASKE1020
 1021 QERDVDIRGS IDVEKVVIKL FDGYDWKYTR KFIANTVEKL DKELSKAEAS SSKSNVPQSE1080
 1081 ANIFDSIYIS ANKNNVTDLR RNLDGEIQGV QNSFSDVSKV NLRPSKHYKA LIQLNKVHVN1140
 1141 LKNYRVDEPD ESNSDNSTDV LNRCVVSIYE FEIIDNVPTS TWNKFVTLLK HEPWPHSSPM1200
 1201 FLLDLEFIRP IDFLQAVELV MQLNVAPLRL HVDQDTLEFL IRFLGFKDKR FELIDEYPDI1260
 1261 VFIQKFSTNS IKLRLDYKPK KVDYAGLRSG QTSELMNFFT LDGSKIILKS VVLYGLNGFD1320
 1321 ELNNKLKAIW TPDITKKQLP GVLEGLAPVR SFMAIGSGVK TLVTVLMSEY RQEGHLGRSL1380
 1381 KKGGNVFLKT TTGDFVKLGV KLTSGTQAIL ENTEELFGGV GSNGRVYDAS KFGSADGADS1440
 1441 DTAAVLDLDT LFEEDQLVGS KYSRIRDHEP TAVVIDMSSP GDHNEPTIVS LYADQPLDLP1500
 1501 TGLKEAYSSL EKHMHIAYDA VWRAKGQMKD DKRGGPSAAA VYVARAAPVA IIRPLIGATE1560
 1561 AVSKTLQGIA NQVDKTHNEQ INDKYKSNRT DS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ATG18 ATG2
    View Details Krogan NJ, et al. (2006) ATG2 MAS1 MAS2
    View Details Gavin AC, et al. (2002) ADH1 ATG18 ATG2
    View Details Ho Y, et al. (2002) ATG18 ATG2 CDC55 SAP155
    View Details Qiu et al. (2008) ATG1 ATG11 ATG16 ATG2 ATG20 ATG8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HMT1 ATG2 1 Unpublished Fields Lab Data
    View Screen UBC6 ATG2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ATG2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1209] deduced N/A No confident structure predictions are available.
    2 View Details [1210..1592] MSA 3.011913 View MSA. No confident structure predictions are available.
    3 View Details [283..362] deduced N/A No confident structure predictions are available.
    4 View Details [363..479] deduced N/A No confident structure predictions are available.
    5 View Details [480..635] deduced N/A No confident structure predictions are available.
    6 View Details [636..779] deduced N/A No confident structure predictions are available.
    7 View Details [780..1012] deduced N/A No confident structure predictions are available.
    8 View Details [1013..1251] deduced N/A No confident structure predictions are available.
    9 View Details [1252..1414] MSA 4.046996 View MSA. No confident structure predictions are available.
    10 View Details [1415..1592] Pfam 54.30103 No description for PF09333.2 was found. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle