Protein Overview: GCR2

General Information:
Name(s) found:	GCR2 / YNL199C [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	534 amino acids
Gene Ontology:
Cellular Component:	nucleus [IC ]
Biological Process:	positive regulation of transcription from RNA polymerase II promoter [IMP] positive regulation of glycolysis [IMP]
Molecular Function:	transcription activator activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHHQTKLDVF IIRAYNLLSN ESVISGASLQ SVTNSPQTTT NTPSGMVNGA VGTGIANPTG  60
   61 LMGSDSTPNI DEIITSTGSN ALTKTNSDSA NGTPNGNSSS TSAISNASNP ATTGNNASSS 120
  121 ATSNGIYTQA QYSQLFAKIS KLYNATLSSG SIDDRSTSPK SAIELYQRFQ QMIKELELSF 180
  181 DASPYAKYFR RLDGRLWQIK TDSELENDEL WRLVSMSIFT VFDPQTGQIL TQGRRKGNSL 240
  241 NTSTKGSPSD LQGINNGNNN GNNGNIGNGS NIKNYGNKNM PNNRTKKRGT RVAKNAKNGK 300
  301 NNKNSNKERN GITDTSAFSN TTISNPGTNM LFDPSLSQQL QKRLQTLSQD VNSRSLTGYY 360
  361 TQPTSPGSGG FEFGLSHADL NPNASSNTMG YNTMSNNGSH SWKRRSLGSL DVNTLDDEAV 420
  421 EELLQLTNTS KRQRPMTTAA EGALINDGPD TNLNANNTQM KVDLNPSNSM GPIDTEAVIR 480
  481 PLKEAYDAII SEKGQRIVQL ERELELQRQE TQWLRKMLIE DMGCVRSMLR DLQR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		GCR1 GCR2
View Details	Ho Y, et al. (2002)		CDC25 CKI1 GCR2 GIN4 HOM3 IRA1 IRA2 MYO2 MYO4 NAP1 PMD1 PRS2 PRS3 PRS5 RIM11 TPS1 TSL1 YDR170W-A YER138C YER160C YJR027W YJR028W

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	GDI1	GCR2	1	Unpublished Fields Lab Data
View Screen	YPT1	GCR2	1	Unpublished Fields Lab Data
View Screen	AML1	GCR2	1	Unpublished Fields Lab Data
View Screen	NPA3	GCR2	1	Unpublished Fields Lab Data
View Screen	YJU2	GCR2	1	Unpublished Fields Lab Data
View Screen	PUF3	GCR2	1	Unpublished Fields Lab Data
View Screen	NUP2	GCR2	1	Unpublished Fields Lab Data
View Screen	SPT21	GCR2	1	Unpublished Fields Lab Data
View Screen	YNL260C	GCR2	1	Unpublished Fields Lab Data
View Screen	MPD1	GCR2	1	Unpublished Fields Lab Data
View Screen	ATG12	GCR2	1	Unpublished Fields Lab Data
View Screen	LSM4	GCR2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..157]	MSA	1.002946	View MSA. No confident structure predictions are available.
2	View Details	[158..237]	deduced	N/A	Confident ab initio structure predictions are available.
3	View Details	[238..318]	MSA	1.002996	View MSA. No confident structure predictions are available.
4	View Details	[319..534]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2