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Protein Overview: NMA111

General Information:
Name(s) found: NMA111 / YNL123W [SGD]
Description(s) found:
Found 37 descriptions.
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  • Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 997 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    Biological Process: lipid metabolic process [IMPLink to PubMed article][IPILink to PubMed article]
    apoptosis [IMPLink to PubMed articleLink to PubMed article][ISSLink to PubMed articleLink to PubMed article]
    Molecular Function: serine-type peptidase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTISLSNIKK RDHSKISDGT SGESSLVKRK QLESATGDQE EEYTDHEIII EPLHFANNNN  60
   61 TVLTDSENYL RWQNTISNVV KSVVSIHFSQ VAPFDCDSAL VSEATGFVVD AKLGIILTNR 120
  121 HVVGPGPFVG YVVFDNHEEC DVIPIYRDPV HDFGFLKFDP KNIKYSKIKA LTLKPSLAKV 180
  181 GSEIRVVGND AGEKLSILAG FISRIDRNAP EYGELTYNDF NTEYIQAAAS ASGGSSGSPV 240
  241 VNIDGYAVAL QAGGSTEAST DFFLPLDRIL RALICIQTNK PITRGTIQVQ WLLKPYDECR 300
  301 RLGLTSERES EARAKFPENI GLLVAETVLR EGPGYDKIKE GDTLISINGE TISSFMQVDK 360
  361 IQDENVGKEI QLVIQRGGVE CTVTCTVGDL HAITPHRYVE VCGATFHELS YQMARFYALP 420
  421 VRGVFLSSAS GSFNFDSKER VGWIVDSIDN KETPDLDTFI EIMKTIPDRK RVTVRYHHLT 480
  481 DQHSPLVTSI YIDRHWCNEF RVYTRNDTTG IWDYKNVADP LPADALKPRS AKIIPIPVNN 540
  541 EKVAKLSSSL CTVATMAAVP LDSLSADILK TSGLIIDAEK GYVLVSRRVV PHDCLDTFVT 600
  601 IADSLVVPAT VEFLHPTHNF AIVKYDPELV KAPLITPKLS TTRMKRGDKL QFIGFTQNDR 660
  661 IVTSETTVTD ISSVSIPSNL IPRYRATNLE AISIDCNVST RCNSGILTDN DGTVRGLWLP 720
  721 FLGERLENKE KVYLMGLDIM DCREVIDILK NGGKPRVSIV DAGFGSISVL QARIRGVPEE 780
  781 WIMRMEHESN NRLQFITVSR VSYTEDKIHL ETGDVILSVN GKLVTEMNDL NGVVSSADGI 840
  841 LPSAMLDFKV VRDGNIVDLK IKTVEVQETD RFVIFAGSIL QKPHHAVLQA MVDVPKGVYC 900
  901 TFRGESSPAL QYGISATNFI THVNEIETPD LDTFLKVVKT IPDNSYCKMR LMTFDNVPFA 960
  961 ISLKTNYHYF PTAELKRDNI THKWIEKEFT GNSQSEK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NMA111 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..295] PSI-BLAST 135.522879 Mitochondrial serine protease HtrA2; Mitochondrial serine protease HtrA2, catalytic domain
    2 View Details [296..388] PSI-BLAST 135.522879 Mitochondrial serine protease HtrA2; Mitochondrial serine protease HtrA2, catalytic domain
    3 View Details [389..506] PSI-BLAST 6.69897 Photosystem II D1 C-terminal processing protease
    4 View Details [507..756] PSI-BLAST 156.201249 Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain
    5 View Details [757..997] PSI-BLAST 156.201249 Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  4.29457766519035 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.89864153190117 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.83715255212076 bayes_pls_golite062009
  • serine hydrolase activity
    		•  3.10188179747851 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  3.09356744910628 bayes_pls_golite062009
  • hydrolase activity
    		•  2.95731933344861 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  2.91265669601085 bayes_pls_golite062009
  • catalytic activity
    		•  1.40927913545237 bayes_pls_golite062009
  • protein binding
    		•  1.32810553079123 bayes_pls_golite062009
  • binding
    		•  0.714540979086077 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.51799784310141 bayes_pls_golite062009
  • protein C-terminus binding
    		•  0.285650646146901 bayes_pls_golite062009
  • DNA binding
    		•  0.166098452144962 bayes_pls_golite062009
  • enzyme binding
    		•  0.0323607861080599 bayes_pls_golite062009
    2
    Term Confidence Notes
  • protein binding
    		•  3.43316749555592 bayes_pls_golite062009
  • binding
    		•  2.66667167586056 bayes_pls_golite062009
  • protein C-terminus binding
    		•  0.285650646146901 bayes_pls_golite062009
  • hydrolase activity
    		•  0.167877702757621 bayes_pls_golite062009
  • enzyme binding
    		•  0.0323607861080599 bayes_pls_golite062009
    3
    Term Confidence Notes
  • protein binding
    		•  3.43316749555592 bayes_pls_golite062009
  • binding
    		•  2.66667167586056 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.51799784310141 bayes_pls_golite062009
  • protein C-terminus binding
    		•  0.285650646146901 bayes_pls_golite062009
  • hydrolase activity
    		•  0.167877702757621 bayes_pls_golite062009
  • DNA binding
    		•  0.166098452144962 bayes_pls_golite062009
  • enzyme binding
    		•  0.0323607861080599 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle