YRC Public Data Repository - Protein Structure Prediction

Protein:	NMA111
Organism:	Saccharomyces cerevisiae
Length:	997 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NMA111.

Description	E-value	Query Range	Subject Range
NM111_YEAS7 - Pro-apoptotic serine protease NMA111 OS=Saccharomyces cerevisiae (strain YJM789) GN=NMA111 PE=3 SV=1 NMA111 - Serine protease and general molecular chaperone; involved in response to heat stress and promotion o... NM111_YEAST - Pro-apoptotic serine protease NMA111 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NMA...	0.0	[1..997]	[1..997]
YIFC_SCHPO - PDZ domain-containing protein C23G3.12c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SP... SPAC23G3.12c - serine protease	0.0	[7..997]	[2..971]
gi\|229344317, gi... - gi\|229519628\|ref\|ZP_04409071.1\| outer membrane stress sensor protease DegQ [Vibrio cholerae RC9], gi... gi\|229342095, gi... - gi\|229520862\|ref\|ZP_04410284.1\| outer membrane stress sensor protease DegQ [Vibrio cholerae TM 11079... gi\|227080749, gi... - gi\|227080749\|ref\|YP_002809300.1\| protease DO [Vibrio cholerae M66-2], gi\|227008637\|gb\|ACP04849.1\| pr... gi\|229507177, gi... - gi\|229507177\|ref\|ZP_04396683.1\| outer membrane stress sensor protease DegQ [Vibrio cholerae BX 33028... gi\|15640588, gi\|... - gi\|9654996\|gb\|AAF93734.1\| protease DO [Vibrio cholerae O1 biovar El Tor str. N16961], gi\|15640588\|re... gi\|11278798 - pir\|\|F82307 proteinase DO VC0566 [imported] - Vibrio cholerae (strain N16961 serogroup O1) gi\|229606145, gi... - gi\|229606145\|ref\|YP_002876793.1\| outer membrane stress sensor protease DegQ [Vibrio cholerae MJ-1236... gi\|121591583, gi... - gi\|121591583\|ref\|ZP_01678838.1\| protease DO [Vibrio cholerae 2740-80], gi\|121546565\|gb\|EAX56765.1\| p... gi\|124120842, gi... - gi\|153803624\|ref\|ZP_01958210.1\| protease DO [Vibrio cholerae MZO-3], gi\|124120842\|gb\|EAY39585.1\| pro... gi\|153224050, gi... - gi\|153224050\|ref\|ZP_01954195.1\| protease DO [Vibrio cholerae MAK 757], gi\|124117870\|gb\|EAY36613.1\| p... gi\|126518367, gi... - gi\|229509162\|ref\|ZP_04398647.1\| outer membrane stress sensor protease DegQ [Vibrio cholerae B33], gi... gi\|125617304 - gi\|125617304\|gb\|EAZ45876.1\| protease DO [Vibrio cholerae MO10] gi\|153830227, gi... - gi\|153830227\|ref\|ZP_01982894.1\| protease DO [Vibrio cholerae 623-39], gi\|148874287\|gb\|EDL72422.1\| pr... gi\|147673156, gi... - gi\|227116942\|ref\|YP_002818838.1\| protease DO [Vibrio cholerae O395], gi\|227012392\|gb\|ACP08602.1\| pro...	4.0E-80	[517..964]	[37..456]
DEGPL_CHLMU - Probable periplasmic serine endoprotease DegP-like OS=Chlamydia muridarum (strain MoPn / Nigg) GN=ht... DEGP_CHLMU, DEGP... - Probable serine protease do-like OS=Chlamydia muridarum GN=degP PE=3 SV=1, Probable periplasmic seri...	6.0E-79	[520..967]	[73..497]
gi\|15618887, gi\|... - gi\|4377306\|gb\|AAD19116.1\| DO Serine Protease [Chlamydophila pneumoniae CWL029], gi\|15618887\|ref\|NP_2... gi\|8979352, gi\|1... - gi\|8979352\|dbj\|BAA99186.1\| DO serine protease [Chlamydophila pneumoniae J138], gi\|15836510\|ref\|NP_30... DEGPL_CHLPN - Probable periplasmic serine endoprotease DegP-like OS=Chlamydia pneumoniae GN=htrA PE=3 SV=1	1.0E-78	[469..967]	[15..488]
gi\|7189789, gi\|1... - gi\|7189789\|gb\|AAF38665.1\| serine protease, HtrA/DegQ/DegS family [Chlamydophila pneumoniae AR39], gi... gi\|11278801 - gi\|11278801\|pir\|\|G81528 serine proteinase, HtrA/DegQ/DegS family CP0877 [imported] - Chlamydophila p...	1.0E-78	[469..967]	[15..488]
gi\|16762108 - gi\|16762108\|ref\|NP_457725.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Typhi ... gi\|213648052 - gi\|213648052\|ref\|ZP_03378105.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Typ... gi\|213865023 - gi\|213865023\|ref\|ZP_03387142.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Typ... gi\|16504411, gi\|... - gi\|25305547\|pir\|\|AB0909 serine protease (EC 3.4.21.-) [imported] - Salmonella enterica subsp. enteri... gi\|29139232, gi\|... - gi\|29143597\|ref\|NP_806939.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Typhi ... gi\|213052237 - gi\|213052237\|ref\|ZP_03345115.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Typ... gi\|213424379 - gi\|213424379\|ref\|ZP_03357202.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Typ... gi\|213580506 - gi\|213580506\|ref\|ZP_03362332.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Typ... gi\|213609411 - gi\|213609411\|ref\|ZP_03369237.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Typ... gi\|56129533, gi\|... - gi\|56415276\|ref\|YP_152351.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Paraty... gi\|197364206, gi... - gi\|197364206\|ref\|YP_002143843.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Pa...	1.0E-78	[511..964]	[32..455]
gi\|12963467 - gi\|12963467\|gb\|AAK11276.1\|AF343973_1 MucD [Pseudomonas aeruginosa] gi\|115583903, gi... - gi\|116048682\|ref\|YP_792518.1\| serine protease MucD precursor [Pseudomonas aeruginosa UCBPP-PA14], gi...	7.0E-78	[50..480]	[8..463]
gi\|255317964 - gi\|255317964\|ref\|ZP_05359210.1\| DO Serine protease [Chlamydia trachomatis 6276s] gi\|255311663 - gi\|255311663\|ref\|ZP_05354233.1\| DO Serine protease [Chlamydia trachomatis 6276] DEGPL_CHLTR - Probable periplasmic serine endoprotease DegP-like OS=Chlamydia trachomatis (strain D/UW-3/Cx) GN=ht... DEGPL_CHLTR, DEG... - Probable serine protease do-like OS=Chlamydia trachomatis GN=degP PE=3 SV=2, Probable periplasmic se...	8.0E-78	[520..967]	[73..497]

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Predicted Domain #1

Region A:
Residues: [1-295]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTISLSNIKK RDHSKISDGT SGESSLVKRK QLESATGDQE EEYTDHEIII EPLHFANNNN  60
   61 TVLTDSENYL RWQNTISNVV KSVVSIHFSQ VAPFDCDSAL VSEATGFVVD AKLGIILTNR 120
  121 HVVGPGPFVG YVVFDNHEEC DVIPIYRDPV HDFGFLKFDP KNIKYSKIKA LTLKPSLAKV 180
  181 GSEIRVVGND AGEKLSILAG FISRIDRNAP EYGELTYNDF NTEYIQAAAS ASGGSSGSPV 240
  241 VNIDGYAVAL QAGGSTEAST DFFLPLDRIL RALICIQTNK PITRGTIQVQ WLLKP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	135.522879
Match:	1lcyA_
Description:	Mitochondrial serine protease HtrA2; Mitochondrial serine protease HtrA2, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	4.29457766519035	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.89864153190117	bayes_pls_golite062009
endopeptidase activity	3.83715255212076	bayes_pls_golite062009
serine hydrolase activity	3.10188179747851	bayes_pls_golite062009
serine-type peptidase activity	3.09356744910628	bayes_pls_golite062009
hydrolase activity	2.95731933344861	bayes_pls_golite062009
serine-type endopeptidase activity	2.91265669601085	bayes_pls_golite062009
catalytic activity	1.40927913545237	bayes_pls_golite062009
protein binding	1.32810553079123	bayes_pls_golite062009
binding	0.714540979086077	bayes_pls_golite062009
nucleic acid binding	0.51799784310141	bayes_pls_golite062009
protein C-terminus binding	0.285650646146901	bayes_pls_golite062009
DNA binding	0.166098452144962	bayes_pls_golite062009
enzyme binding	0.0323607861080599	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [296-388]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDECRRLGLT SERESEARAK FPENIGLLVA ETVLREGPGY DKIKEGDTLI SINGETISSF  60
   61 MQVDKIQDEN VGKEIQLVIQ RGGVECTVTC TVG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	135.522879
Match:	1lcyA_
Description:	Mitochondrial serine protease HtrA2; Mitochondrial serine protease HtrA2, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	3.43316749555592	bayes_pls_golite062009
binding	2.66667167586056	bayes_pls_golite062009
protein C-terminus binding	0.285650646146901	bayes_pls_golite062009
hydrolase activity	0.167877702757621	bayes_pls_golite062009
enzyme binding	0.0323607861080599	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [389-506]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLHAITPHRY VEVCGATFHE LSYQMARFYA LPVRGVFLSS ASGSFNFDSK ERVGWIVDSI  60
   61 DNKETPDLDT FIEIMKTIPD RKRVTVRYHH LTDQHSPLVT SIYIDRHWCN EFRVYTRN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.69897
Match:	1fc7A_
Description:	Photosystem II D1 C-terminal processing protease
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	3.43316749555592	bayes_pls_golite062009
binding	2.66667167586056	bayes_pls_golite062009
nucleic acid binding	0.51799784310141	bayes_pls_golite062009
protein C-terminus binding	0.285650646146901	bayes_pls_golite062009
hydrolase activity	0.167877702757621	bayes_pls_golite062009
DNA binding	0.166098452144962	bayes_pls_golite062009
enzyme binding	0.0323607861080599	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [507-756]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTTGIWDYKN VADPLPADAL KPRSAKIIPI PVNNEKVAKL SSSLCTVATM AAVPLDSLSA  60
   61 DILKTSGLII DAEKGYVLVS RRVVPHDCLD TFVTIADSLV VPATVEFLHP THNFAIVKYD 120
  121 PELVKAPLIT PKLSTTRMKR GDKLQFIGFT QNDRIVTSET TVTDISSVSI PSNLIPRYRA 180
  181 TNLEAISIDC NVSTRCNSGI LTDNDGTVRG LWLPFLGERL ENKEKVYLMG LDIMDCREVI 240
  241 DILKNGGKPR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	156.201249
Match:	1ky9A_
Description:	Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [757-997]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSIVDAGFGS ISVLQARIRG VPEEWIMRME HESNNRLQFI TVSRVSYTED KIHLETGDVI  60
   61 LSVNGKLVTE MNDLNGVVSS ADGILPSAML DFKVVRDGNI VDLKIKTVEV QETDRFVIFA 120
  121 GSILQKPHHA VLQAMVDVPK GVYCTFRGES SPALQYGISA TNFITHVNEI ETPDLDTFLK 180
  181 VVKTIPDNSY CKMRLMTFDN VPFAISLKTN YHYFPTAELK RDNITHKWIE KEFTGNSQSE 240
  241 K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	156.201249
Match:	1ky9A_
Description:	Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: