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Protein Overview: PRC1

General Information:
Name(s) found: PRC1 / YMR297W [SGD]
Description(s) found:
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  • gi|6323955|ref|NP_014026.1| Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; Prc1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|530354|emb|CAA56806.1| carboxypeptidase Y precursor [Saccharomyces cerevisiae] [NCBI NR]
  • pir||CPBYY carboxypeptidase C (EC 3.4.16.5) precursor [validated] - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|172239|gb|AAA34902.1| protein carboxypeptidase Y precursor [NCBI NR]
  • gi|115901|sp|P00729.1|CBPY_YEAST RecName: Full=Carboxypeptidase Y; AltName: Full=Carboxypeptidase YSCY; Flags: Precursor [NCBI NR]
  • Carboxypeptidase Y OS=Saccharomyces cerevisiae GN=PRC1 PE=1 SV=1 [Swiss-Prot]
  • PRC1 Carboxypeptidase y, serine-type protease [mips]
  • Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family [SGD]
  • PRC1, Chr XIII from 861922-863520 [yeast_orfs2]
  • Chr XIII from 861922-863520 [yeastorf3.fasta]
  • (P00729) Carboxypeptidase Y precursor (EC 3.4.16.5) (Carboxypeptidase YSCY) [4932.FASTACCERV.txt]
  • PRC1 SGDID:S0004912, Chr XIII from 861921-863519, Verified ORF [yeastflysequest.fasta]
  • Prc1p [Saccharomyces cerevisiae]gi|530354|emb|CAA56806.1| carboxypeptidase Y precursor [Saccharomyces cerevisiae]gi|279561|pir||CPBYY carboxypeptidase C (EC 3.4.16.5) precursor [validated] - yeast (Saccharomyces cerevisiae)gi|172239|gb|AAA34902.1| prot [nrdb_11152004_Chlamydomonas]
  • PRC1 SGDID:S000004912, Chr XIII from 861921-863519, Verified ORF, "Vacuolar carboxypeptidase Y (proteinase C), involved in protein degradation in the vacuole and required for full protein degradation during sporulation" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PRC1 SGDID:S000004912, Chr XIII from 861921-863519, Verified ORF, "Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase fam [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Carboxypeptidase Y precursor (Carboxypeptidase YSCY) [nr-271106-contam.fasta]
  • protein carboxypeptidase Y precursor [nr-271106-contam.fasta]
  • Vacuolar carboxypeptidase Y (proteinase C), involved in protein degradation in the vacuole and required for full protein degradation during sporulation; Prc1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • carboxypeptidase Y precursor [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PRC1 SGDID:S000004912, Chr XIII from 861921-863519, Verified ORF, "Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidas [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • PRC1 SGDID:S000004912, Chr XIII from 861921-863519, Verified ORF, "Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • PRC1 SGDID:S000004912, Chr XIII from 861921-863519, Verified ORF, "Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family" [SGDyeast.20101221.fasta]
  • Carboxypeptidase Y OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRC1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PRC1 SGDID:S000004912, Chr XIII from 861922-863520, Genome Release 64-1-1, Verified ORF, "Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family" [yeast-030211-contam.fasta]
  • PRC1 SGDID:S000004912, Chr XIII from 861922-863520, Genome Release 64-2-1, Verified ORF, "Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family" [20141208_orf_trans.fasta]
  • YMR297W SGDID:S000004912, Chr XIII from 861922-863520, Genome Release 64-1-1, Verified ORF, "Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 532 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    fungal-type vacuole lumen [TASLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    fungal-type vacuole [IDALink to PubMed article]
    Biological Process: vacuolar protein catabolic process [TASLink to PubMed article]
    Molecular Function: carboxypeptidase C activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAFTSLLCG LGLSTTLAKA ISLQRPLGLD KDVLLQAAEK FGLDLDLDHL LKELDSNVLD  60
   61 AWAQIEHLYP NQVMSLETST KPKFPEAIKT KKDWDFVVKN DAIENYQLRV NKIKDPKILG 120
  121 IDPNVTQYTG YLDVEDEDKH FFFWTFESRN DPAKDPVILW LNGGPGCSSL TGLFFELGPS 180
  181 SIGPDLKPIG NPYSWNSNAT VIFLDQPVNV GFSYSGSSGV SNTVAAGKDV YNFLELFFDQ 240
  241 FPEYVNKGQD FHIAGESYAG HYIPVFASEI LSHKDRNFNL TSVLIGNGLT DPLTQYNYYE 300
  301 PMACGEGGEP SVLPSEECSA MEDSLERCLG LIESCYDSQS VWSCVPATIY CNNAQLAPYQ 360
  361 RTGRNVYDIR KDCEGGNLCY PTLQDIDDYL NQDYVKEAVG AEVDHYESCN FDINRNFLFA 420
  421 GDWMKPYHTA VTDLLNQDLP ILVYAGDKDF ICNWLGNKAW TDVLPWKYDE EFASQKVRNW 480
  481 TASITDEVAG EVKSYKHFTY LRVFNGGHMV PFDVPENALS MVNEWIHGGF SL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CRP1 IDS2 PDR1 PEP4 PRC1 RTN1 SIA1
    View Details Gavin AC, et al. (2006) ADH1 PRC1
    View Details Qiu et al. (2008) APE3 COS2, COS3 CPS1 ECM14 LAP4 PEP4 PRB1 PRC1 YBR139W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PRC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] deduced N/A No confident structure predictions are available.
    2 View Details [79..282]
    [376..416]    		 PSI-BLAST 10157.0 Serine carboxypeptidase II
    3 View Details [283..375]
    [417..532]    		 PSI-BLAST 10157.0 Serine carboxypeptidase II

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • hydrolase activity
    		•  4.09944423676394 bayes_pls_golite062009
  • peptidase activity
    		•  2.49064988313037 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.10044305272656 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.83678475999803 bayes_pls_golite062009
  • palmitoyl-(protein) hydrolase activity
    		•  1.46950384675756 bayes_pls_golite062009
  • catalytic activity
    		•  1.39629727416851 bayes_pls_golite062009
  • palmitoyl-CoA hydrolase activity
    		•  0.815337671271829 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  0.49805374409569 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.43631945855397 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle