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Protein Overview: APE3

General Information:
Name(s) found: APE3 / YBR286W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Vacuolar aminopeptidase Y, processed to mature form by Prb1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 537 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    vacuolar protein catabolic process [IDALink to PubMed article]
    Molecular Function: aminopeptidase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHFSLKQLAV AAFYATNLGS AYVIPQFFQE AFQQEEPIEN YLPQLNDDDS SAVAANIPKP  60
   61 HIPYFMKPHV ESEKLQDKIK VDDLNATAWD LYRLANYSTP DYGHPTRVIG SKGHNKTMEY 120
  121 ILNVFDDMQD YYDVSLQEFE ALSGKIISFN LSDAETGKSF ANTTAFALSP PVDGFVGKLV 180
  181 EIPNLGCEEK DYASVVPPRH NEKQIALIER GKCPFGDKSN LAGKFGFTAV VIYDNEPKSK 240
  241 EGLHGTLGEP TKHTVATVGV PYKVGKKLIA NIALNIDYSL YFAMDSYVEF IKTQNIIADT 300
  301 KHGDPDNIVA LGAHSDSVEE GPGINDDGSG TISLLNVAKQ LTHFKINNKV RFAWWAAEEE 360
  361 GLLGSNFYAY NLTKEENSKI RVFMDYDMMA SPNYEYEIYD ANNKENPKGS EELKNLYVDY 420
  421 YKAHHLNYTL VPFDGRSDYV GFINNGIPAG GIATGAEKNN VNNGKVLDRC YHQLCDDVSN 480
  481 LSWDAFITNT KLIAHSVATY ADSFEGFPKR ETQKHKEVDI LNAQQPQFKY RADFLII

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) APE3 SEH1
    View Details Qiu et al. (2008) APE3 LAP4 PEP4 PRC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data APE3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..56] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [57..138] ORFEUS 12.05 Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain
    3 View Details [139..224] ORFEUS 12.05 Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain
    4 View Details [225..537] PSI-BLAST 379.218487 Aminopeptidase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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