Protein Overview: ALD2

General Information:
Name(s) found:	ALD2 / YMR170C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|825575\|emb\|CAA89806.1\| Ald2p [Saccharomyces cerevisiae] [NCBI NR] gi\|6323822\|ref\|NP_013893.1\| Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p; Ald2p [Saccharomyc [NCBI NR] gi\|1706382\|sp\|P47771.2\|ALDH2_YEAST RecName: Full=Aldehyde dehydrogenase [NAD(P)+] 1 [NCBI NR] (P47771) Aldehyde dehydrogenase [NAD(P)+] 1 (EC 1.2.1.5) [Swiss-Prot] Aldehyde dehydrogenase [NAD(P)+] 1 OS=Saccharomyces cerevisiae GN=ALD2 PE=1 SV=2 [Swiss-Prot] ALD2 Aldehyde dehydrogenase 2 (NAD+) [mips] Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p [SGD] ALD2, Chr XIII from 601561-603081, reverse complement [yeast_orfs2] Chr XIII from 601561-603081, reverse complement [yeastorf3.fasta] Chr XIII from 603081-601561, reverse complement [yeastorf5.fasta] ALD2 SGDID:S0004780, Chr XIII from 603081-601561, reverse complement, Verified ORF [yeastflysequest.fasta] Ald2p [Saccharomyces cerevisiae]gi\|825575\|emb\|CAA89806.1\| Ald2p [Saccharomyces cerevisiae]gi\|1706382\|sp\|P47771\|DHA2_YEAST Aldehyde dehydrogenase [NAD(P)+] 1 [nrdb_11152004_Chlamydomonas] ALD2 SGDID:S000004780, Chr XIII from 603081-601561, reverse complement, Verified ORF, "Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and g [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p; Ald2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Aldehyde dehydrogenase [NAD(P)+] 1 [nr-271106-contam.fasta] Ald2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ALD2 SGDID:S000004780, Chr XIII from 603081-601561, reverse complement, Verified ORF, "Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Aldehyde dehydrogenase [NAD(P)+] 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ALD2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ALD2 SGDID:S000004780, Chr XIII from 603082-601562, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p" [yeast-030211-contam.fasta] ALD2 SGDID:S000004780, Chr XIII from 603082-601562, Genome Release 64-2-1, reverse complement, Verified ORF, "Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p" [20141208_orf_trans.fasta] YMR170C SGDID:S000004780, Chr XIII from 603082-601562, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	506 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA][ISS]
Biological Process:	cellular aldehyde metabolic process [ISS] beta-alanine biosynthetic process [IMP] polyamine catabolic process [IGI][IMP]
Molecular Function:	3-chloroallyl aldehyde dehydrogenase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT SFQAANEKDV  60
   61 DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT LAALETLDAG KPYHSNAKGD 120
  121 LAQILQLTRY FAGSADKFDK GATIPLTFNK FAYTLKVPFG VVAQIVPWNY PLAMACWKLQ 180
  181 GALAAGNTVI IKPAENTSLS LLYFATLIKK AGFPPGVVNI VPGYGSLVGQ ALASHMDIDK 240
  241 ISFTGSTKVG GFVLEASGQS NLKDVTLECG GKSPALVFED ADLDKAIDWI AAGIFYNSGQ 300
  301 NCTANSRVYV QSSIYDKFVE KFKETAKKEW DVAGKFDPFD EKCIVGPVIS STQYDRIKSY 360
  361 IERGKREEKL DMFQTSEFPI GGAKGYFIPP TIFTDVPQTS KLLQDEIFGP VVVVSKFTNY 420
  421 DDALKLANDT CYGLASAVFT KDVKKAHMFA RDIKAGTVWI NSSNDEDVTV PFGGFKMSGI 480
  481 GRELGQSGVD TYLQTKAVHI NLSLDN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ALD2 ALD3 YLR143W YPF1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#31 Asynchronous Prep (Protease cleavage)	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SPT23	ALD2	1	Unpublished Fields Lab Data
View Screen	RAS2	ALD2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ALD2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..269] [474..506]	PSI-BLAST	2260.0	Aldehyde reductase (dehydrogenase), ALDH
2	View Details	[270..473]	PSI-BLAST	2260.0	Aldehyde reductase (dehydrogenase), ALDH

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
oxidoreductase activity, acting on the aldehyde or oxo group of donors	5.09598561374689	bayes_pls_golite062009
oxidoreductase activity	4.47226217021998	bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity	4.35175408702761	bayes_pls_golite062009
malonate-semialdehyde dehydrogenase (acetylating) activity	4.2273960318884	bayes_pls_golite062009
methylmalonate-semialdehyde dehydrogenase (acylating) activity	3.87605237828483	bayes_pls_golite062009
succinate-semialdehyde dehydrogenase [NAD(P)+] activity	3.64672165191647	bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity	3.37049090049734	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	3.2867555127991	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	2.99564252244797	bayes_pls_golite062009
aldehyde dehydrogenase (NAD) activity	2.81851373615334	bayes_pls_golite062009
catalytic activity	2.80804701752928	bayes_pls_golite062009
glutamate-5-semialdehyde dehydrogenase activity	2.78416888468693	bayes_pls_golite062009
succinate-semialdehyde dehydrogenase activity	2.71501590413507	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors	2.70230501280821	bayes_pls_golite062009
aldehyde dehydrogenase [NAD(P)+] activity	2.43250909158896	bayes_pls_golite062009
aminobutyraldehyde dehydrogenase activity	2.35958138496479	bayes_pls_golite062009
acyl-CoA binding	2.26220696569489	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	1.6559690223037	bayes_pls_golite062009
retinal dehydrogenase activity	1.42867174920845	bayes_pls_golite062009
electron carrier activity	1.33390667257376	bayes_pls_golite062009
binding	1.06673666884196	bayes_pls_golite062009
retinoid binding	0.983782635681687	bayes_pls_golite062009
isoprenoid binding	0.900374761028287	bayes_pls_golite062009
protein binding	0.894945263794726	bayes_pls_golite062009
hydrolase activity	0.799513645745266	bayes_pls_golite062009
histidinol dehydrogenase activity	0.258030369394064	bayes_pls_golite062009
benzaldehyde dehydrogenase (NAD+) activity	0.23487570676521	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2