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View Structure Prediction Details

Protein: ALD2
Organism: Saccharomyces cerevisiae
Length: 506 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ALD2.

Description E-value Query
Range		 Subject
Range
AL1A1_SHEEP - Retinal dehydrogenase 1 OS=Ovis aries GN=ALDH1A1 PE=1 SV=2
 0.0 [1..506] [1..500]
AL1A1_BOVIN - Retinal dehydrogenase 1 - Bos taurus (Bovine)
 0.0 [1..506] [1..500]
AL1A1_CHICK - Retinal dehydrogenase 1 OS=Gallus gallus GN=ALDH1A1 PE=2 SV=1
 0.0 [8..506] [15..508]
AL1A7_MOUSE - Aldehyde dehydrogenase, cytosolic 1 OS=Mus musculus GN=Aldh1a7 PE=1 SV=1
 0.0 [1..506] [1..500]
AL1A1_RAT - Retinal dehydrogenase 1 OS=Rattus norvegicus GN=Aldh1a1 PE=1 SV=3
 0.0 [1..506] [1..500]
AL1A1_HORSE - Retinal dehydrogenase 1 OS=Equus caballus GN=ALDH1A1 PE=1 SV=1
 0.0 [3..506] [1..499]

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Predicted Domain #1
Region A:
Residues: [1-269] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT SFQAANEKDV  60
   61 DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT LAALETLDAG KPYHSNAKGD 120
  121 LAQILQLTRY FAGSADKFDK GATIPLTFNK FAYTLKVPFG VVAQIVPWNY PLAMACWKLQ 180
  181 GALAAGNTVI IKPAENTSLS LLYFATLIKK AGFPPGVVNI VPGYGSLVGQ ALASHMDIDK 240
  241 ISFTGSTKVG GFVLEASGQS NLKDVTLEC

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [474-506] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFKMSGIGRE LGQSGVDTYL QTKAVHINLS LDN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2260.0
Match: 1bi9A_
Description: Aldehyde reductase (dehydrogenase), ALDH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on the aldehyde or oxo group of donors 5.09598561374689 bayes_pls_golite062009
oxidoreductase activity 4.47226217021998 bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity 4.35175408702761 bayes_pls_golite062009
malonate-semialdehyde dehydrogenase (acetylating) activity 4.2273960318884 bayes_pls_golite062009
methylmalonate-semialdehyde dehydrogenase (acylating) activity 3.87605237828483 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase [NAD(P)+] activity 3.64672165191647 bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity 3.37049090049734 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3.2867555127991 bayes_pls_golite062009
benzaldehyde dehydrogenase activity 2.99564252244797 bayes_pls_golite062009
aldehyde dehydrogenase (NAD) activity 2.81851373615334 bayes_pls_golite062009
catalytic activity 2.80804701752928 bayes_pls_golite062009
glutamate-5-semialdehyde dehydrogenase activity 2.78416888468693 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase activity 2.71501590413507 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors 2.70230501280821 bayes_pls_golite062009
aldehyde dehydrogenase [NAD(P)+] activity 2.43250909158896 bayes_pls_golite062009
aminobutyraldehyde dehydrogenase activity 2.35958138496479 bayes_pls_golite062009
acyl-CoA binding 2.26220696569489 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1.6559690223037 bayes_pls_golite062009
retinal dehydrogenase activity 1.42867174920845 bayes_pls_golite062009
electron carrier activity 1.33390667257376 bayes_pls_golite062009
binding 1.06673666884196 bayes_pls_golite062009
retinoid binding 0.983782635681687 bayes_pls_golite062009
isoprenoid binding 0.900374761028287 bayes_pls_golite062009
protein binding 0.894945263794726 bayes_pls_golite062009
hydrolase activity 0.799513645745266 bayes_pls_golite062009
histidinol dehydrogenase activity 0.258030369394064 bayes_pls_golite062009
benzaldehyde dehydrogenase (NAD+) activity 0.23487570676521 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [270-473] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGKSPALVFE DADLDKAIDW IAAGIFYNSG QNCTANSRVY VQSSIYDKFV EKFKETAKKE  60
   61 WDVAGKFDPF DEKCIVGPVI SSTQYDRIKS YIERGKREEK LDMFQTSEFP IGGAKGYFIP 120
  121 PTIFTDVPQT SKLLQDEIFG PVVVVSKFTN YDDALKLAND TCYGLASAVF TKDVKKAHMF 180
  181 ARDIKAGTVW INSSNDEDVT VPFG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2260.0
Match: 1bi9A_
Description: Aldehyde reductase (dehydrogenase), ALDH
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle