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Protein Overview: PDS5

General Information:
Name(s) found: PDS5 / YMR076C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1277 amino acids

    Gene Ontology:
    Cellular Component: condensed nuclear chromosome [IDALink to PubMed article]
    Biological Process: mitotic chromosome condensation [IMPLink to PubMed article]
    mitotic sister chromatid cohesion [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: structural molecule activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKGAVTKLK FNSPIISTSD QLISTNELLD RLKALHEELA SLDQDNTDLT GLDKYRDALV  60
   61 SRKLLKHKDV GIRAFTACCL SDILRLYAPD APYTDAQLTD IFKLVLSQFE QLGDQENGYH 120
  121 IQQTYLITKL LEYRSIVLLA DLPSSNNLLI ELFHIFYDPN KSFPARLFNV IGGILGEVIS 180
  181 EFDSVPLEVL RLIFNKFLTY NPNEIPEGLN VTSDCGYEVS LILCDTYSNR MSRHLTKYYS 240
  241 EIIHEATNDD NNSRLLTVVV KLHKLVLRLW ETVPELINAV IGFIYHELSS ENELFRKEAT 300
  301 KLIGQILTSY SDLNFVSTHS DTFKAWISKI ADISPDVRVE WTESIPQIIA TREDISKELN 360
  361 QALAKTFIDS DPRVRRTSVM IFNKVPVTEI WKNITNKAIY TSLLHLAREK HKEVRELCIN 420
  421 TMAKFYSNSL NEIERTYQNK EIWEIIDTIP STLYNLYYIN DLNINEQVDS VIFEYLLPFE 480
  481 PDNDKRVHRL LTVLSHFDKK AFTSFFAFNA RQIKISFAIS KYIDFSKFLN NQESMSSSQG 540
  541 PIVMNKYNQT LQWLASGLSD STKAIDALET IKQFNDERIF YLLNACVTND IPFLTFKNCY 600
  601 NELVSKLQTP GLFKKYNIST GASIMPRDIA KVIQILLFRA SPIIYNVSNI SVLLNLSNNS 660
  661 DAKQLDLKRR ILDDISKVNP TLFKDQIRTL KTIIKDLDDP DAEKNDNLSL EEALKTLYKA 720
  721 SKTLKDQVDF DDTFFFTKLY DFAVESKPEI TKYATKLIAL SPKAEETLKK IKIRILPLDL 780
  781 QKDKYFTSHI IVLMEIFKKF PHVLNDDSTD IISYLIKEVL LSNQVVGDSK KEIDWVEDSL 840
  841 LSDTKYSAIG NKVFTLKLFT NKLRSIAPDV PRDELAESFT EKTMKLFFYL IASGGELISE 900
  901 FNKEFYPTPS NYQTKLRCVA GIQVLKLARI SNLNNFIKPS DIIKLINLVE DESLPVRKTF 960
  961 LEQLKDYVAN ELISIKFLPL VFFTAYEPDV ELKTTTKIWI NFTFGLKSFK KGTIFERALP1020
 1021 RLIHAIAHHP DIVGGLDSEG DAYLNALTTA IDYLLFYFDS IAAQENFSLL YYLSERVKNY1080
 1081 QDKLVEDEID EEEGPQKEEA PKKHRPYGQK MYIIGELSQM ILLNLKEKKN WQHSAYPGKL1140
 1141 NLPSDLFKPF ATVQEAQLSF KTYIPESLTE KIQNNIKAKI GRILHTSQTQ RQRLQKRLLA1200
 1201 HENNESQKKK KKVHHARSQA DDEEGDGDRE SDSDDDSYSP SNKNETKKGH ENIVMKKLRV1260
 1261 RKEVDYKDDE DDDIEMT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MSS1 NOP7 NTE1 PDS5 SOP4 STP3 YGR067C YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PDS5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..698] MSA 1.016001 View MSA. No confident structure predictions are available.
    2 View Details [699..840] deduced N/A No confident structure predictions are available.
    3 View Details [841..1196] MSA 2.017915 View MSA. No confident structure predictions are available.
    4 View Details [1197..1277] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle