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Protein Overview: MSN2

General Information:
Name(s) found: MSN2 / YMR037C [SGD]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 704 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: response to oxidative stress [IGILink to PubMed article]
    response to hydrostatic pressure [IGILink to PubMed article]
    heat acclimation [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter in response to stress [IMPLink to PubMed article]
    response to osmotic stress [IGILink to PubMed article]
    response to freezing [IGILink to PubMed article]
    replicative cell aging [IMPLink to PubMed article]
    age-dependent response to oxidative stress involved in chronological cell aging [IMPLink to PubMed article]
    response to stress [IMPLink to PubMed article]
    cellular response to glucose starvation [IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVDHDFNSE DILFPIESMS SIQYVENNNP NNINNDVIPY SLDIKNTVLD SADLNDIQNQ  60
   61 ETSLNLGLPP LSFDSPLPVT ETIPSTTDNS LHLKADSNKN RDARTIENDS EIKSTNNASG 120
  121 SGANQYTTLT SPYPMNDILY NMNNPLQSPS PSSVPQNPTI NPPINTASNE TNLSPQTSNG 180
  181 NETLISPRAQ QHTSIKDNRL SLPNGANSNL FIDTNPNNLN EKLRNQLNSD TNSYSNSISN 240
  241 SNSNSTGNLN SSYFNSLNID SMLDDYVSSD LLLNDDDDDT NLSRRRFSDV ITNQFPSMTN 300
  301 SRNSISHSLD LWNHPKINPS NRNTNLNITT NSTSSSNASP NTTTMNANAD SNIAGNPKNN 360
  361 DATIDNELTQ ILNEYNMNFN DNLGTSTSGK NKSACPSSFD ANAMTKINPS QQLQQQLNRV 420
  421 QHKQLTSSHN NSSTNMKSFN SDLYSRRQRA SLPIIDDSLS YDLVNKQDED PKNDMLPNSN 480
  481 LSSSQQFIKP SMILSDNASV IAKVATTGLS NDMPFLTEEG EQNANSTPNF DLSITQMNMA 540
  541 PLSPASSSST SLATNHFYHH FPQQGHHTMN SKIGSSLRRR KSAVPLMGTV PLTNQQNNIS 600
  601 SSSVNSTGNG AGVTKERRPS YRRKSMTPSR RSSVVIESTK ELEEKPFHCH ICPKSFKRSE 660
  661 HLKRHVRSVH SNERPFACHI CDKKFSRSDN LSQHIKTHKK HGDI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MSN2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] deduced N/A No confident structure predictions are available.
    2 View Details [163..351] MSA 7.63199 View MSA. No confident structure predictions are available.
    3 View Details [352..543] PSI-BLAST 56.274545 Transcription factor IIIA, TFIIIA
    4 View Details [544..630] PSI-BLAST 114.06601 Designed zinc finger protein
    5 View Details [631..704] PSI-BLAST 166.70927 ZIF268

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.64349785387632 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.93314267845352 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.53991278722671 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.10558148421807 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle