Protein Overview: YML045W

General Information:
Name(s) found:	YML045W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6323597\|ref\|NP_013668.1\| Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retrov [NCBI NR] gi\|126302618\|sp\|Q04711.2\|YM11B_YEAST RecName: Full=Transposon Ty1-ML1 Gag-Pol polyprotein; AltName: Full=Gag-Pol-p199; AltName: Full=Transposon Ty1 TYA-TYB polyprotein; AltName: Full=TY1A-TY1B; AltName: Full=p190; Contains: RecName: Full=Capsid protein; S [NCBI NR] Transposon Ty1-ML1 Gag-Pol polyprotein OS=Saccharomyces cerevisiae GN=TY1B-ML1 PE=3 SV=2 [Swiss-Prot] Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [SGD] YML045W, Chr XIII from 184461-185765,185767-189729 [yeast_orfs2] Chr XIII from 184461-185765,185767-189729 [yeastorf3.fasta] YML045W SGDID:S0004508, Chr XIII from 184461-185765,185767-189729, Ty ORF [yeastflysequest.fasta] TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] YML045W SGDID:S000004508, Chr XIII from 184461-185765,185767-189729, transposable_element_gene, "TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YML045W SGDID:S000004508, Chr XIII from 184461-185765,185767-189729, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse tra [yeast-contam.fasta] Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes; Yml045wp [Saccha [nr-271106-contam.fasta] YML045W SGDID:S000004508, Chr XIII from 184461-185765,185767-189729, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Transposon Ty1-ML1 Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY1B-ML1 PE=3 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] YML045W SGDID:S000004508, Chr XIII from 184461-185765,185767-189729, Genome Release 64-1-1, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" [yeast-030211-contam.fasta] Transposon Ty1-ML1 Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY1B-ML1 PE=2 SV=2 [YEAST.fasta.20131015] YML045W SGDID:S000004508, Chr XIII from 184461-185765,185767-189729, Genome Release 64-2-1, transposable_element_gene, "Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" [20141208_orf_trans.fasta]
Organism:	Saccharomyces cerevisiae
Length:	1755 amino acids
Gene Ontology:
Cellular Component:	retrotransposon nucleocapsid [ISS]
Biological Process:	transposition, RNA-mediated [ISS]
Molecular Function:	DNA-directed DNA polymerase activity [ISS] RNA-directed DNA polymerase activity [ISS] RNA binding [ISS] protein binding [ISS] ribonuclease activity [ISS] peptidase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESQQLSNYP NISHGSACAS VTSKEVHTNQ DPLDVSASKI QEYDKASTKA NSQQTTTPAS  60
   61 SAVPENLHHA SPQPASVPPP QNGPYPQQCM MTQNQANPSG WSFYGHPSMI PYTPYQMSPM 120
  121 YFPPGPQSQF PQYPSSVGTP LSTPSPESGN TFTDSSSADS DMTSTKKYVR PPPMLTSPND 180
  181 FPNWVKTYIK FLQNSNLGGI IPTVNGKPVR QITDDELTFL YNTFQIFAPS QFLPTWVKDI 240
  241 LSVDYTDIMK ILSKSIEKMQ SDTQEANDIV TLANLQYNGS TPADAFETKV TNIIDRLNNN 300
  301 GIHINNKVAC QLIMRGLSGE YKFLRYTRHR HLNMTVAELF LDIHAIYEEQ QGSRNSKPNY 360
  361 RRNPSDEKND SRSYTNTTKP KVIARNPQKT NNSKSKTARA HNVSTSNNSP STDNDSISKS 420
  421 TTEPIQLNNK HDLHLGQKLT ESTVNHTNHS DDELPGHLLL DSGASRTLIR SAHHIHSASS 480
  481 NPDINVVDAQ KRNIPINAIG DLQFHFQDNT KTSIKVLHTP NIAYDLLSLN ELAAVDITAC 540
  541 FTKNVLERSD GTVLAPIVKY GDFYWVSKKY LLPSNISVPT INNVHTSEST RKYPYPFIHR 600
  601 MLAHANAQTI RYSLKNNTIT YFNESDVDWS SAIDYQCPDC LIGKSTKHRH IKGSRLKYQN 660
  661 SYEPFQYLHT DIFGPVHNLP KSAPSYFISF TDETTKFRWV YPLHDRREDS ILDVFTTILA 720
  721 FIKNQFQASV LVIQMDRGSE YTNRTLHKFL EKNGITPCYT TTADSRAHGV AERLNRTLLD 780
  781 DCRTQLQCSG LPNHLWFSAI EFSTIVRNSL ASPKSKKSAR QHAGLAGLDI STLLPFGQPV 840
  841 IVNDHNPNSK IHPRGIPGYA LHPSRNSYGY IIYLPSLKKT VDTTNYVILQ GKESRLDQFN 900
  901 YDALTFDEDL NRLTASYQSF IASNEIQQSD DLNIESDHDF QSDIELHPEQ PRNVLSKAVS 960
  961 PTDSTPPSTH TEDSKRVSKT NIRAPREVDP NISESNILPS KKRSSTPQIS NIESTGSGGM1020
 1021 HKLNVPLLAP MSQSNTHESS HASKSKDFRH SDSYSENETN HTNVPISSTG GTNNKTVPQI1080
 1081 SDQETEKRII HRSPSIDASP PENNSSHNIV PIKTPTTVSE QNTEESIIAD LPLPDLPPES1140
 1141 PTEFPDPFKE LPPINSHQTN SSLGGIGDSN AYTTINSKKR SLEDNETEIK VSRDTWNTKN1200
 1201 MRSLEPPRSK KRIHLIAAVK AVKSIKPIRT TLRYDEAITY NKDIKEKEKY IEAYHKEVNQ1260
 1261 LLKMNTWDTD KYYDRKEIDP KRVINSMFIF NRKRDGTHKA RFVARGDIQH PDTYDSGMQS1320
 1321 NTVHHYALMT SLSLALDNNY YITQLDISSA YLYADIKEEL YIRPPPHLGM NDKLIRLKKS1380
 1381 LYGLKQSGAN WYETIKSYLI KQCGMEEVRG WSCVFKNSQV TICLFVDDMI LFSKDLNANK1440
 1441 KIITTLKKQY DTKIINLGES DNEIQYDILG LEIKYQRGKY MKLGMENSLT EKIPKLNVPL1500
 1501 NPKGRKLSAP GQPGLYIDQD ELEIDEDEYK EKVHEMQKLI GLASYVGYKF RFDLLYYINT1560
 1561 LAQHILFPSR QVLDMTYELI QFMWDTRDKQ LIWHKNKPTE PDNKLVAISD ASYGNQPYYK1620
 1621 SQIGNIYLLN GKVIGGKSTK ASLTCTSTTE AEIHAISESV PLLNNLSHLV QELNKKPITK1680
 1681 GLLTDSKSTI SIIISNNEEK FRNRFFGTKA MRLRDEVSGN HLHVCYIETK KNIADVMTKP1740
 1741 LPIKTFKLLT NKWIH

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		YAR009C YBL005W-B YBR012W-B YCL019W YDR210C-C YDR210C-D YDR365W-B YER138C YER159C-A, YDR31... YER160C YFL002W-A, YGR161W-B YGR027W-B YGR038C-B YHR214C-B YIL080W YIL082W-A YJR027W YJR029W YLR157C-B YML039W YML045W YMR050C YNL284C-B YOR343W-A YOR343W-B

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	HIR2	No Comments	Green EM, et al (2005)
View Run	RLF2	cac1: TAP-tagged	Green EM, et al (2005)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	RLF2	phosphorylation data - cascade search	Green EM, et al (2005)
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)
View Run	MLP2	#04 Alpha Factor Prep2	Keck JM, et al. (2011)
View Run	MLP2	#06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CPR6	YML045W	1	Unpublished Fields Lab Data
View Screen	SWC4	YML045W	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)