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Protein Overview: NFT1

General Information:
Name(s) found: NFT1 / YKR103W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds. [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1218 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISSLink to PubMed article]
    Biological Process: transport [ISSLink to PubMed article]
    Molecular Function: ATPase activity, coupled to transmembrane movement of substances [ISSLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKNGTCPYW ERDDLSECAR REYIEFKFPL FILLTGMIYA FCKVFRAFYL RGKNHTNEAP  60
   61 EFEEQGNGNH EYARFSVLRL KSAWESRSFC NVNNRSTFDK FKKFIEGAFI VLQLTIHLYI 120
  121 LSSMPMDNKK FFHQGFLVQM FLWILLLVVI TLRLISASQS FRWVLACKRD LWAVSFYSYA 180
  181 SLFTLSILPL RSVFIGKIKD KIMVKYIISE TFIDLALLLL LSTSSIEGTR YSFLVENENK 240
  241 KLPPAPTVFG LLTFSRIDRL IWKAYKHCLG NADIWDLDIN NKSIAILANF EMSSKKGRLL 300
  301 PNIICYFKAV FISQLFLAFV SSFLNFVPSL LMPRILSYVN DPKSKSWNLV SLYVSSMLVS 360
  361 KIIATTCRGQ GLFLGEKGTM QLRTVLISNI YSKTLRRTIL KDSTTSLQKN ASTSFEENPD 420
  421 SSEAEPRKKS SRKDNSVNNV MSIDAFKVSE AMNTFYLACE AVFMTVTALM ILYSLLGWSA 480
  481 FAGTFALLAM IPLNFWCATF YGNYQADQLI LTDKRTSGIS EALNSIRVIK LLAWENLFYQ 540
  541 KIINVRDGEI RLLKKKATIF FLNHLIWFFG PTLVSAITFS VFIKFQNQTL TPTIAFTALS 600
  601 LFAILRTPMD QIASTVSLLI QSFISLERIQ DYLNESETRK YEILEQSNTK FGFEDASMEW 660
  661 EAAETSFKLK NISIDFKLNS LNAIIGPTGS GKSSLLLGLL GELNLLSGKI YVPTVESRDD 720
  721 LEIGKDGMTN SMAYCSQTPW LISGTIKDNV VFGEIFNKQK FDDVMKSCCL DKDIKAMTAG 780
  781 IRTDVGDGGF SLSGGQQQRI ALARAIYSSS RYLILDDCLS AVDPETALYI YEECLCGPMM 840
  841 KGRTCIITSH NISLVTKRAD WLVILDRGEV KSQGKPSDLI KSNEFLRESI NNDSKNTTHN 900
  901 QIDLKRSTTS KKTKNGDPEG GNSQDEVCAE VENFEETKME GSVKFSAYKW LADYFGGLGV 960
  961 VFVFTSSSIL IHGITLSQGF WLRYWLDTGS SGSKSTWLYR IVEGHSNIYF LLTYIIIGLV1020
 1021 SSFLTSGKVW IAIISGTNVT KKIFAKLLSS ILYAKLRFHN VTPTGRIMNR FSKDMDIIDQ1080
 1081 QLIPNFEGLS YSVVVCLWII LLIGYVTPQF LLFAIPLCAL YYTVCTLYLR ASRELKRIDN1140
 1141 INISPIHQLF AEAIKGVTTI RALADERRFI TQSLVAIDRS NAPFFYLNMA TEWITYRVDI1200
 1201 IGTLVLFSSS VMIIMKAS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GOR1 NFT1 PET122

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NFT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..268] MSA 1.226974 View MSA. No confident structure predictions are available.
    2 View Details [269..406]
    [439..634]    		 PSI-BLAST 333.9897 MsbA
    3 View Details [407..438]
    [635..909]    		 PSI-BLAST 333.9897 MsbA
    4 View Details [910..997] deduced N/A No confident structure predictions are available.
    5 View Details [998..1218] ORFEUS 7.95 Cytoplasmic domain of a serine chemotaxis receptor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • ATPase activity, coupled to transmembrane movement of substances
    		•  5.57844095962502 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  5.5689620139321 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  5.55992639965745 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  5.50005167063544 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  4.98276715440477 bayes_pls_golite062009
  • ATPase activity
    		•  4.69795387297193 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  4.45923622153365 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  4.39781350157199 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  4.38133275795019 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  4.38085303582726 bayes_pls_golite062009
  • transporter activity
    		•  3.71239480053329 bayes_pls_golite062009
  • hydrolase activity
    		•  3.14498892233323 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.13960906549884 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.1318898376276 bayes_pls_golite062009
  • ATP binding
    		•  3.01346604299372 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  2.97119034312001 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  2.96271391116269 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  2.91131545957759 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  2.70262534541085 bayes_pls_golite062009
  • ribonucleotide binding
    		•  2.70178191749524 bayes_pls_golite062009
  • purine nucleotide binding
    		•  2.6583477492092 bayes_pls_golite062009
  • nucleotide binding
    		•  2.62374702628143 bayes_pls_golite062009
    		• 2.20174656498665 bayes_pls_golite062009
  • lipid transporter activity
    		•  1.74534601529986 bayes_pls_golite062009
  • peptide-transporting ATPase activity
    		•  1.37783759788533 bayes_pls_golite062009
  • peptide transporter activity
    		•  1.19353064661766 bayes_pls_golite062009
  • binding
    		•  1.18037907589281 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.08692822631118 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.213018989352421 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • motor activity
    		•  0.0492636236578701 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • ATPase activity, coupled to transmembrane movement of substances
    		•  5.4467861893359 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  5.44654566127945 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  5.44654566127945 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  5.43909190876515 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  5.4304944906989 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  5.38112407181712 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  4.87869064889244 bayes_pls_golite062009
  • ATPase activity
    		•  4.60773943958528 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  4.38591214726007 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  4.32673473878039 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  4.31087891816858 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  4.31037981322306 bayes_pls_golite062009
  • transporter activity
    		•  3.47953169973151 bayes_pls_golite062009
  • hydrolase activity
    		•  3.11706952898443 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.94175800357966 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.90743799425416 bayes_pls_golite062009
  • ATP binding
    		•  2.83986218503994 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  2.79195527951815 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  2.74359323245512 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  2.55506944753783 bayes_pls_golite062009
  • ribonucleotide binding
    		•  2.55426312645972 bayes_pls_golite062009
  • purine nucleotide binding
    		•  2.51344800975739 bayes_pls_golite062009
  • nucleotide binding
    		•  2.48057252852174 bayes_pls_golite062009
  • lipid transporter activity
    		•  1.22217924457225 bayes_pls_golite062009
  • binding
    		•  1.15406183540658 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.04118164915515 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle