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View Structure Prediction Details

Protein: NFT1
Organism: Saccharomyces cerevisiae
Length: 1218 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NFT1.

Description E-value Query
Range		 Subject
Range
gi|29502090, gi|... - gi|7404488|sp|P36028.2|NFT1_YEAST RecName: Full=ABC transporter NFT1; AltName: Full=New full-length ...
 0.0 [1..1218] [1..1218]
gi|149029024, gi... - gi|7739773|gb|AAF69007.1|AF257746_1 multidrug resistance protein 1a [Rattus norvegicus], gi|62646634...
 0.0 [282..1217] [21..953]
ABCB1 - ATP-binding cassette, sub-family B (MDR/TAP), member 1
gi|117645528 - gi|117645528|emb|CAL38230.1| hypothetical protein [synthetic construct]
 0.0 [280..1217] [20..961]
MDR3_MOUSE - Multidrug resistance protein 3 OS=Mus musculus GN=Abcb1a PE=2 SV=2
 0.0 [282..1217] [21..957]
gi|57526446, gi|... - gi|57526446|ref|NP_001009790.1| ATP-binding cassette, subfamily B, member 1 [Ovis aries], gi|2149087...
 0.0 [282..1217] [26..966]
gi|8926217 - gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance glycoprotein MDR1 [synthetic construct]
 0.0 [264..1217] [11..969]
MDR1_CRIGR - Multidrug resistance protein 1 OS=Cricetulus griseus GN=ABCB1 PE=1 SV=2
 0.0 [271..1217] [10..958]

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Predicted Domain #1
Region A:
Residues: [1-268] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKNGTCPYW ERDDLSECAR REYIEFKFPL FILLTGMIYA FCKVFRAFYL RGKNHTNEAP  60
   61 EFEEQGNGNH EYARFSVLRL KSAWESRSFC NVNNRSTFDK FKKFIEGAFI VLQLTIHLYI 120
  121 LSSMPMDNKK FFHQGFLVQM FLWILLLVVI TLRLISASQS FRWVLACKRD LWAVSFYSYA 180
  181 SLFTLSILPL RSVFIGKIKD KIMVKYIISE TFIDLALLLL LSTSSIEGTR YSFLVENENK 240
  241 KLPPAPTVFG LLTFSRIDRL IWKAYKHC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [269-406] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGNADIWDLD INNKSIAILA NFEMSSKKGR LLPNIICYFK AVFISQLFLA FVSSFLNFVP  60
   61 SLLMPRILSY VNDPKSKSWN LVSLYVSSML VSKIIATTCR GQGLFLGEKG TMQLRTVLIS 120
  121 NIYSKTLRRT ILKDSTTS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [439-634] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVMSIDAFKV SEAMNTFYLA CEAVFMTVTA LMILYSLLGW SAFAGTFALL AMIPLNFWCA  60
   61 TFYGNYQADQ LILTDKRTSG ISEALNSIRV IKLLAWENLF YQKIINVRDG EIRLLKKKAT 120
  121 IFFLNHLIWF FGPTLVSAIT FSVFIKFQNQ TLTPTIAFTA LSLFAILRTP MDQIASTVSL 180
  181 LIQSFISLER IQDYLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 333.9897
Match: 1jsqA_
Description: MsbA
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [407-438] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQKNASTSFE ENPDSSEAEP RKKSSRKDNS VN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [635-909] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESETRKYEIL EQSNTKFGFE DASMEWEAAE TSFKLKNISI DFKLNSLNAI IGPTGSGKSS  60
   61 LLLGLLGELN LLSGKIYVPT VESRDDLEIG KDGMTNSMAY CSQTPWLISG TIKDNVVFGE 120
  121 IFNKQKFDDV MKSCCLDKDI KAMTAGIRTD VGDGGFSLSG GQQQRIALAR AIYSSSRYLI 180
  181 LDDCLSAVDP ETALYIYEEC LCGPMMKGRT CIITSHNISL VTKRADWLVI LDRGEVKSQG 240
  241 KPSDLIKSNE FLRESINNDS KNTTHNQIDL KRSTT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 333.9897
Match: 1jsqA_
Description: MsbA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ATPase activity, coupled to transmembrane movement of substances 5.57844095962502 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 5.57813579764186 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 5.57813579764186 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 5.5689620139321 bayes_pls_golite062009
primary active transmembrane transporter activity 5.55992639965745 bayes_pls_golite062009
active transmembrane transporter activity 5.50005167063544 bayes_pls_golite062009
ATPase activity, coupled 4.98276715440477 bayes_pls_golite062009
ATPase activity 4.69795387297193 bayes_pls_golite062009
nucleoside-triphosphatase activity 4.45923622153365 bayes_pls_golite062009
pyrophosphatase activity 4.39781350157199 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 4.38133275795019 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4.38085303582726 bayes_pls_golite062009
transporter activity 3.71239480053329 bayes_pls_golite062009
hydrolase activity 3.14498892233323 bayes_pls_golite062009
transmembrane transporter activity 3.13960906549884 bayes_pls_golite062009
substrate-specific transporter activity 3.1318898376276 bayes_pls_golite062009
ATP binding 3.01346604299372 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
adenyl ribonucleotide binding 2.96271391116269 bayes_pls_golite062009
adenyl nucleotide binding 2.91131545957759 bayes_pls_golite062009
purine ribonucleotide binding 2.70262534541085 bayes_pls_golite062009
ribonucleotide binding 2.70178191749524 bayes_pls_golite062009
purine nucleotide binding 2.6583477492092 bayes_pls_golite062009
nucleotide binding 2.62374702628143 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
lipid transporter activity 1.74534601529986 bayes_pls_golite062009
peptide-transporting ATPase activity 1.37783759788533 bayes_pls_golite062009
peptide transporter activity 1.19353064661766 bayes_pls_golite062009
binding 1.18037907589281 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.08692822631118 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.213018989352421 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
motor activity 0.0492636236578701 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [910-997] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKKTKNGDPE GGNSQDEVCA EVENFEETKM EGSVKFSAYK WLADYFGGLG VVFVFTSSSI  60
   61 LIHGITLSQG FWLRYWLDTG SSGSKSTW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [998-1218] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYRIVEGHSN IYFLLTYIII GLVSSFLTSG KVWIAIISGT NVTKKIFAKL LSSILYAKLR  60
   61 FHNVTPTGRI MNRFSKDMDI IDQQLIPNFE GLSYSVVVCL WIILLIGYVT PQFLLFAIPL 120
  121 CALYYTVCTL YLRASRELKR IDNINISPIH QLFAEAIKGV TTIRALADER RFITQSLVAI 180
  181 DRSNAPFFYL NMATEWITYR VDIIGTLVLF SSSVMIIMKA S

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.95
Match: 1qu7A
Description: Cytoplasmic domain of a serine chemotaxis receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ATPase activity, coupled to transmembrane movement of substances 5.4467861893359 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 5.44654566127945 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 5.44654566127945 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 5.43909190876515 bayes_pls_golite062009
primary active transmembrane transporter activity 5.4304944906989 bayes_pls_golite062009
active transmembrane transporter activity 5.38112407181712 bayes_pls_golite062009
ATPase activity, coupled 4.87869064889244 bayes_pls_golite062009
ATPase activity 4.60773943958528 bayes_pls_golite062009
nucleoside-triphosphatase activity 4.38591214726007 bayes_pls_golite062009
pyrophosphatase activity 4.32673473878039 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 4.31087891816858 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4.31037981322306 bayes_pls_golite062009
transporter activity 3.47953169973151 bayes_pls_golite062009
hydrolase activity 3.11706952898443 bayes_pls_golite062009
transmembrane transporter activity 2.94175800357966 bayes_pls_golite062009
substrate-specific transporter activity 2.90743799425416 bayes_pls_golite062009
ATP binding 2.83986218503994 bayes_pls_golite062009
adenyl ribonucleotide binding 2.79195527951815 bayes_pls_golite062009
adenyl nucleotide binding 2.74359323245512 bayes_pls_golite062009
purine ribonucleotide binding 2.55506944753783 bayes_pls_golite062009
ribonucleotide binding 2.55426312645972 bayes_pls_golite062009
purine nucleotide binding 2.51344800975739 bayes_pls_golite062009
nucleotide binding 2.48057252852174 bayes_pls_golite062009
lipid transporter activity 1.22217924457225 bayes_pls_golite062009
binding 1.15406183540658 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.04118164915515 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle