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Protein Overview: DAD2

General Information:
Name(s) found: DAD2 / YKR083C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 133 amino acids

    Gene Ontology:
    Cellular Component: DASH complex [IDALink to PubMed articleLink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed articleLink to PubMed article]
    spindle [IDALink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed article]
    Biological Process: mitotic spindle organization in nucleus [IMPLink to PubMed article]
    regulation of microtubule polymerization or depolymerization [IDALink to PubMed article][IPILink to PubMed article]
    Molecular Function: structural constituent of cytoskeleton [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSIDEQIAI KRKELQSLQK ITSLTDGLKI QLTELNEQIK EMGMNADSVA QLMNNWDSII  60
   61 NNISQASLGL LQYAEGDYEI GPWKDSKKKE SEQSNETGLE AQENDKNDED NDEDEDLVPL 120
  121 PETMVRIRVD GNE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ASK1 DAD1 DAD2 DAM1 DUO1 SPC19 SPC34
    View Details (MIPS) Mewes HW, et al. (2004) ASK1 DAD1 DAD2 DAD3 DAD4 DAM1 DUO1 SPC19 SPC34
    View Details Krogan NJ, et al. (2006) DAD2 DAD3 YMR075C-A
    View Details Qiu et al. (2008) ARP10 ASK1 BBP1 DAD1 DAD2 DAD3 DAD4 DAM1 DUO1 HSK3 SPC19 SPC34

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 No Comments Cheeseman IM, et al. (2002)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ATG17 DAD2 2 Drees BL, et al. (2001)
    View Screen YDR131C DAD2 1 Unpublished Fields Lab Data
    View Screen PHS1 DAD2 1 Unpublished Fields Lab Data
    View Screen RPT1 DAD2 1 Unpublished Fields Lab Data
    View Screen NUP2 DAD2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data DAD2 Huh WK, et al. (2003)
    View Data DAD2 and SPC42 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..133] Pfam 73.431798 No description for PF08654.1 was found. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle