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Protein Overview: PRS1

General Information:
Name(s) found: PRS1 / YKL181W [SGD]
Description(s) found:
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  • gi|6322667|ref|NP_012740.1| 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; Prs1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|486319|emb|CAA82024.1| PRPS1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|4244|emb|CAA49674.1| ribose-phosphate pyrophosphokinase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|417226|sp|P32895.1|KPR1_YEAST RecName: Full=Ribose-phosphate pyrophosphokinase 1; AltName: Full=Phosphoribosyl pyrophosphate synthetase 1 [NCBI NR]
  • gi|395244|emb|CAA52257.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S30558 ribose-phosphate diphosphokinase (EC 2.7.6.1) PRPS1 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|172274|gb|AAA21811.1| phosphoribosylpyrophosphate synthetase [Saccharomyces cerevisiae] [NCBI NR]
  • Ribose-phosphate pyrophosphokinase 1 OS=Saccharomyces cerevisiae GN=PRS1 PE=1 SV=1 [Swiss-Prot]
  • PRS1 Ribose-phosphate pyrophosphokinase [mips]
  • 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [SGD]
  • PRS1, Chr XI from 107318-108601 [yeast_orfs2]
  • Chr XI from 107318-108601 [yeastorf3.fasta]
  • Chr XI from 107317-108600 [yeastorf4.fasta]
  • (P32895) Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthetase 1) [4932.FASTACCERV.txt]
  • PRS1 SGDID:S0001664, Chr XI from 107321-108604, Verified ORF [yeastflysequest.fasta]
  • 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of a five related enzymes, which are active as heteromultimeric complexes [Saccharomyces cerevisiae]gi|4244|emb|CAA49674.1| ribose-ph [nrdb_11152004_Chlamydomonas]
  • PRS1 SGDID:S000001664, Chr XI from 107321-108604, Verified ORF, "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complex [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PRS1 SGDID:S000001664, Chr XI from 107321-108604, Verified ORF, "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • phosphoribosylpyrophosphate synthetase [nr-271106-contam.fasta]
  • ribose-phosphate pyrophosphokinase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; Prs1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ribose-phosphate pyrophosphokinase 1 (Phosphoribosyl pyrophosphate synthetase 1) [nr-271106-contam.fasta]
  • PRPS1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PRS1 SGDID:S000001664, Chr XI from 107321-108604, Verified ORF, "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes" [yeast-bovrabprots.fasta]
  • PRS1 SGDID:S000001664, Chr XI from 107321-108604, Verified ORF, "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Ribose-phosphate pyrophosphokinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRS1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PRS1 SGDID:S000001664, Chr XI from 107316-108599, Genome Release 64-1-1, Verified ORF, "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes" [yeast-030211-contam.fasta]
  • PRS1 SGDID:S000001664, Chr XI from 107316-108599, Genome Release 64-2-1, Verified ORF, "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease" [20141208_orf_trans.fasta]
  • TR2040|c0_g1_i1|g.1419 ORF TR2040|c0_g1_i1|g.1419 TR2040|c0_g1_i1|m.1419 type:complete len:428 (+) TR2040|c0_g1_i1:219-1502(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YKL181W SGDID:S000001664, Chr XI from 107316-108599, Genome Release 64-1-1, Verified ORF, "5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_6491|g.4843 ORF asmbl_6491|g.4843 asmbl_6491|m.4843 type:complete len:428 (+) asmbl_6491:219-1502(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_6726|g.4041 ORF ID=asmbl_6726|g.4041 ID=asmbl_6726|m.4041 type:complete len:428 (+) ID=asmbl_6726:218-1501(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 427 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: 'de novo' pyrimidine base biosynthetic process [TASLink to PubMed article]
    tryptophan biosynthetic process [TASLink to PubMed article]
    'de novo' IMP biosynthetic process [TASLink to PubMed article]
    histidine biosynthetic process [TASLink to PubMed article]
    purine ribonucleoside salvage [TASLink to PubMed article]
    Molecular Function: ribose phosphate diphosphokinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKCKIFVGN SHPELGNMVC QRLGIEPAPC TLKKFANGET SVQIGVSVRD EDVYVIQSGS  60
   61 PSINDDIMEL LILVSACRGG SARKITAVIP QFPYSKQCKM KRHRGAITAR MLANLLVMAG 120
  121 ADHVVSMDLH ASQMQGFFTK PVDNLYGGPS LAKWIRENVE DYEDAVVVSK NPGGTKRVTA 180
  181 LADSLKINFA MIHTDRRRSK DLYSQNKDLQ QLKLRKQSML RKNRPIIRQG DHPNEEENII 240
  241 LSNGIQTARI RNGHVIGDDE ADDDEDAILE SDSELHSIDG LDSHGLGGTY DAVDSEDEEE 300
  301 IPVLYREQLI TLVGNVRGRS AIILDDMIDR PGSFISAAEH LVQNCGAKKV YVVATHGIFT 360
  361 GDCLEELEKS DAIDTIVVTN TYPISGERIA GSKKLVTIDV SPIFAECIRR DHYGESISVL 420
  421 FDSLAAL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) PRS1 PRS3
    View Details Qiu et al. (2008) PRS1 PRS3 PRS4 PRS5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CTF13 PRS1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PRS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..145]
    [293..314]    		 PSI-BLAST 484.0 Phosphoribosylpyrophosphate synthetase
    2 View Details [146..292] PSI-BLAST 484.0 Phosphoribosylpyrophosphate synthetase
    3 View Details [315..427] PSI-BLAST 39.154902 Glutamine PRPP amidotransferase, C-terminal domain; Glutamine PRPP amidotransferase, N-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.57

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle