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Protein Overview: PRS1

General Information:
Name(s) found: PRS1 / YKL181W [SGD]
Description(s) found:
Found 34 descriptions.
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  • 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 427 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: 'de novo' pyrimidine base biosynthetic process [TASLink to PubMed article]
    tryptophan biosynthetic process [TASLink to PubMed article]
    'de novo' IMP biosynthetic process [TASLink to PubMed article]
    histidine biosynthetic process [TASLink to PubMed article]
    purine ribonucleoside salvage [TASLink to PubMed article]
    Molecular Function: ribose phosphate diphosphokinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKCKIFVGN SHPELGNMVC QRLGIEPAPC TLKKFANGET SVQIGVSVRD EDVYVIQSGS  60
   61 PSINDDIMEL LILVSACRGG SARKITAVIP QFPYSKQCKM KRHRGAITAR MLANLLVMAG 120
  121 ADHVVSMDLH ASQMQGFFTK PVDNLYGGPS LAKWIRENVE DYEDAVVVSK NPGGTKRVTA 180
  181 LADSLKINFA MIHTDRRRSK DLYSQNKDLQ QLKLRKQSML RKNRPIIRQG DHPNEEENII 240
  241 LSNGIQTARI RNGHVIGDDE ADDDEDAILE SDSELHSIDG LDSHGLGGTY DAVDSEDEEE 300
  301 IPVLYREQLI TLVGNVRGRS AIILDDMIDR PGSFISAAEH LVQNCGAKKV YVVATHGIFT 360
  361 GDCLEELEKS DAIDTIVVTN TYPISGERIA GSKKLVTIDV SPIFAECIRR DHYGESISVL 420
  421 FDSLAAL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) PRS1 PRS3
    View Details Qiu et al. (2008) PRS1 PRS3 PRS4 PRS5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PRS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..145]
    [293..314]    		 PSI-BLAST 484.0 Phosphoribosylpyrophosphate synthetase
    2 View Details [146..292] PSI-BLAST 484.0 Phosphoribosylpyrophosphate synthetase
    3 View Details [315..427] PSI-BLAST 39.154902 Glutamine PRPP amidotransferase, C-terminal domain; Glutamine PRPP amidotransferase, N-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.57

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle