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Protein Overview: KTI12

General Information:
Name(s) found: KTI12 / YKL110C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 313 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: tRNA modification [IMPLink to PubMed article]
    cell growth [IPILink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IGILink to PubMed article]
    Molecular Function: chromatin binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLVLFTGYP CSGKTTLAKH LVQLLQSKID ATPSLSKYSI TYHSDESLGI KHSDYITSQD  60
   61 ERKLRSEIIS AVKRDLSKNK IVIVDSLNYI KGFRYQLHCE VKNLSTTFCV IQTLCPPETI 120
  121 FEWNKTSNPN PWEPELLNQL IQRYEEPNSS NRWDSPLFAI LTPQDNITDY IDDICKVVFQ 180
  181 TSKSAKNSGH NDPLSKGLQK PNSATVLKPA SQSNFIQVLD IETSKIIKTI MNHIKSLTSI 240
  241 GGVSNGTRVI VSEGITDIND DGCFFVDLPI GNVVTLAQLQ RLKRQFINFN KLRDIDQDRI 300
  301 GPLFADYLNK NLN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ELP2 ELP3 ELP4 IKI1 IKI3 KTI12 YIL096C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data KTI12 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..217] PSI-BLAST 24.221849 Adenylate kinase; Microbial and mitochondrial ADK, insert "zinc finger" domain
    2 View Details [218..313] PSI-BLAST 3.522879 ATP sulfurylase N-terminal domain; ATP sulfurylase central domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.923452757551011 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.923391844349459 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.920821955769652 bayes_pls_golite062009
  • nucleotide binding
    		•  0.917754212279227 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.81256037545135 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.74918137191219 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.69117331267457 bayes_pls_golite062009
  • ATP binding
    		•  0.60527666756293 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.573214556107072 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.554530910579109 bayes_pls_golite062009
  • ligase activity
    		•  0.417681194526243 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.243902356228423 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • kinase activity
    		•  0.163756462988596 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009
  • RNA binding
    		•  0.0261282189186349 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle