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Protein Overview: TTI1

General Information:
Name(s) found: TTI1 / YKL033W [SGD]
Description(s) found:
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  • gi|6322819|ref|NP_012892.1| Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YKL033W is an essential gene; Ykl033wp [Saccharomyces cerevisiae] [NCBI NR]
  • gi|549666|sp|P36097.1|TTI1_YEAST RecName: Full=TEL2-interacting protein 1 [NCBI NR]
  • pir||S37854 hypothetical protein YKL033w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|486036|emb|CAA81868.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Uncharacterized protein YKL033W OS=Saccharomyces cerevisiae GN=YKL033W PE=1 SV=1 [Swiss-Prot]
  • TEL2-interacting protein 1 OS=Saccharomyces cerevisiae GN=TTI1 PE=1 SV=1 [Swiss-Prot]
  • Protein of unknown function [mips]
  • Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies [SGD]
  • YKL033W, Chr XI from 375094-378210 [yeast_orfs2]
  • Chr XI from 375094-378210 [yeastorf3.fasta]
  • (P36097) Hypothetical 118.9 kDa protein in PTM1-IXR1 intergenic region [4932.FASTACCERV.txt]
  • FMP47 SGDID:S0001516, Chr XI from 375099-378215, Uncharacterized ORF [yeastflysequest.fasta]
  • Fmp47p [Saccharomyces cerevisiae]gi|486036|emb|CAA81868.1| unnamed protein product [Saccharomyces cerevisiae]gi|539154|pir||S37854 hypothetical protein YKL033w - yeast (Saccharomyces cerevisiae)gi|549666|sp|P36097|YKD3_YEAST HYPOTHETICAL 118.9 KD PROTE [nrdb_11152004_Chlamydomonas]
  • YKL033W SGDID:S000001516, Chr XI from 375099-378215, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YKL033W is an essential gene" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YKL033W SGDID:S000001516, Chr XI from 375099-378215, Uncharacterized ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YKL033W is an essential gene" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • TTI1 SGDID:S000001516, Chr XI from 375099-378215, Verified ORF, "Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti1p; detected in highly purified mitochondria in [yeast-200209-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Hypothetical 118.9 kDa protein in PTM1-IXR1 intergenic region [nr-271106-contam.fasta]
  • Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YKL033W is an essential gene; Ykl033wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • TTI1 SGDID:S000001516, Chr XI from 375099-378215, Verified ORF, "Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • TEL2-interacting protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TTI1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TTI1 SGDID:S000001516, Chr XI from 375456-378572, Genome Release 64-1-1, Verified ORF, "Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies" [yeast-030211-contam.fasta]
  • TTI1 SGDID:S000001516, Chr XI from 375456-378572, Genome Release 64-2-1, Verified ORF, "Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies" [20141208_orf_trans.fasta]
  • YKL033W SGDID:S000001516, Chr XI from 375456-378572, Genome Release 64-1-1, Verified ORF, "Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1038 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSDTNAFKD IRISCVELSR IAFLPTESFD PNSLTLLACL KKVEEKLSAY EDDSLSPKFA  60
   61 DYVFVPIASL LKQPALGESQ TEYVLLIIFH LLRTCWSSNG KFSEQLGQQL FPLITFLVSS 120
  121 DKDNQKLITR SDEFKYAGCL VLHQFFKSVR SQRYHKEFFS NSKPNLLPAL GHSVTILLKI 180
  181 LEQSPQNNEL QFKALASLEV LFQDIISDGE MLSFILPGNV SVFAKILTKP GRQIHYKVCV 240
  241 RTLEVLAKLL VLVYDDFSLD IKVNKLTDIR ELSDTKLKHE INQSFMFNGP IVLLRTDGKT 300
  301 HRDTSWLTAT SGQINIALEA FIPKLLKRNN ESIDEALATF VSILLTRCEN SLNNCEKVLV 360
  361 STLVHLERDP MSKLPSHLVK LKEVVNEDLH KLSDIIRFEN ADRLSSLSFA ITILEKNNER 420
  421 DTMINEVVRC LFESLNESIE PPSLINHKER IIEQSSQLTT TVNFENLEST NALIALPRLS 480
  481 EDMSLKLKKF TYHMGSLLLE RHILNDVVTE LISEQVDSPR TQKIVALWLS TNFIKAMEKQ 540
  541 PKEEEVYLQF ESDANYSSSM VEEVCLIVLE FCNELSQDIS MEIEGKGIKK SDEFAVCTVL 600
  601 FSIETICAVM REEFQPELID YIYTVVDALA SPSEAIRYVS QSCALRIADT LYHGSIPNMI 660
  661 LSNVDYLVES ISSRLNSGMT ERVSQILMVI CQLAGYETIE NFKDVIETIF KLLDYYHGYS 720
  721 DLCLQFFQLF KIIILEMKKK YINDDEMILK IANQHISQST FSPWGMTDFQ QVLNILDKET 780
  781 QVKDDITDEN DVDFLKDDNE PSNFQEYFDS KLREPDSDDD EEEREEEVEG SSKEYTDQWT 840
  841 SPIPSDSYKI LLQILGYGER LLTHPSKRLR VQILIVMRLI FPLLSTQHNL LIREVASTWD 900
  901 SIIQCVLCSD YSIVQPACSC VEQMIKYSGD FVAKRFIELW QKLCQDSFIL KELRIDPTVH 960
  961 NHEKKSISKH VKFPPVTENA LVSMVHMVLE GVKITEYLIS EAVLEQIIYC CIQVVPVEKI1020
 1021 SSMSLIVGDI VWKIRNIN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TTI1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173] Pcons 1.84 beta-Catenin
    2 View Details [174..282] Pcons 1.84 beta-Catenin
    3 View Details [283..389] Pcons 1.84 beta-Catenin
    4 View Details [390..431] Pcons 1.84 beta-Catenin
    5 View Details [432..554] Pcons 1.84 beta-Catenin
    6 View Details [555..974] MSA 2.006913 View MSA. No confident structure predictions are available.
    7 View Details [975..1038] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.96084803796407 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.2915564382469 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.78626120336243 bayes_pls_golite062009
  • structural molecule activity
    		•  1.66038601649515 bayes_pls_golite062009
  • DNA binding
    		•  1.62962293446832 bayes_pls_golite062009
  • protein binding
    		•  1.61131270705552 bayes_pls_golite062009
  • transcription factor activity
    		•  0.931585995872658 bayes_pls_golite062009
  • translation regulator activity
    		•  0.642878560112121 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.620348955429476 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.594620724124658 bayes_pls_golite062009
  • RNA binding
    		•  0.243875756041061 bayes_pls_golite062009
  • protein kinase activity
    		•  0.0590061807192209 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.00858493919409042 bayes_pls_golite062009
  • transcription activator activity
    		•  0.005251231402011 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle