YRC Public Data Repository - Protein Structure Prediction

Protein:	TTI1
Organism:	Saccharomyces cerevisiae
Length:	1038 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TTI1.

Description	E-value	Query Range	Subject Range
TTI1_YEAST - TEL2-interacting protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TTI1 PE=1 SV=... TTI1 - Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin re...	0.0	[1..1038]	[1..1038]
SPCC622.13c - conserved eukaryotic protein TTI1_SCHPO - TEL2-interacting protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=tti1 PE=1 SV=1	0.0	[44..987]	[48..979]
CG16908-PA - This gene is referred to in FlyBase by the symbol Dmel\CG16908 (CG16908, FBgn0037741). It is a prote...	0.0	[82..937]	[65..953]
K406_MOUSE, K040... - (Q91V83) Protein KIAA0406, Uncharacterized protein KIAA0406 homolog OS=Mus musculus PE=1 SV=1	0.0	[7..394]	[10..383]
gi\|6634031 - gi\|6634031\|dbj\|BAA23702.2\| KIAA0406 protein [Homo sapiens]	0.0	[7..394]	[16..389]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[7..394]	[10..383]
gi\|37537110, gi\|... - gi\|37537110\|ref\|NP_922857.1\| hypothetical protein [Oryza sativa (japonica cultivar-group)], gi\|31433...	3.0E-95	[598..936]	[799..1146]

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Predicted Domain #1

Region A:
Residues: [1-173]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSDTNAFKD IRISCVELSR IAFLPTESFD PNSLTLLACL KKVEEKLSAY EDDSLSPKFA  60
   61 DYVFVPIASL LKQPALGESQ TEYVLLIIFH LLRTCWSSNG KFSEQLGQQL FPLITFLVSS 120
  121 DKDNQKLITR SDEFKYAGCL VLHQFFKSVR SQRYHKEFFS NSKPNLLPAL GHS

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.84
Match:	1i7wC
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [174-282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTILLKILEQ SPQNNELQFK ALASLEVLFQ DIISDGEMLS FILPGNVSVF AKILTKPGRQ  60
   61 IHYKVCVRTL EVLAKLLVLV YDDFSLDIKV NKLTDIRELS DTKLKHEIN

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.84
Match:	1i7wC
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.96084803796407	bayes_pls_golite062009
nucleic acid binding	2.2915564382469	bayes_pls_golite062009
transcription regulator activity	1.78626120336243	bayes_pls_golite062009
structural molecule activity	1.66038601649515	bayes_pls_golite062009
DNA binding	1.62962293446832	bayes_pls_golite062009
protein binding	1.61131270705552	bayes_pls_golite062009
transcription factor activity	0.931585995872658	bayes_pls_golite062009
translation regulator activity	0.642878560112121	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.620348955429476	bayes_pls_golite062009
translation initiation factor activity	0.594620724124658	bayes_pls_golite062009
RNA binding	0.243875756041061	bayes_pls_golite062009
protein kinase activity	0.0590061807192209	bayes_pls_golite062009
cytoskeletal protein binding	0.00858493919409042	bayes_pls_golite062009
transcription activator activity	0.005251231402011	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [283-389]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSFMFNGPIV LLRTDGKTHR DTSWLTATSG QINIALEAFI PKLLKRNNES IDEALATFVS  60
   61 ILLTRCENSL NNCEKVLVST LVHLERDPMS KLPSHLVKLK EVVNEDL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.84
Match:	1i7wC
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [390-431]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKLSDIIRFE NADRLSSLSF AITILEKNNE RDTMINEVVR CL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.84
Match:	1i7wC
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [432-554]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FESLNESIEP PSLINHKERI IEQSSQLTTT VNFENLESTN ALIALPRLSE DMSLKLKKFT  60
   61 YHMGSLLLER HILNDVVTEL ISEQVDSPRT QKIVALWLST NFIKAMEKQP KEEEVYLQFE 120
  121 SDA

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.84
Match:	1i7wC
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [555-974]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYSSSMVEEV CLIVLEFCNE LSQDISMEIE GKGIKKSDEF AVCTVLFSIE TICAVMREEF  60
   61 QPELIDYIYT VVDALASPSE AIRYVSQSCA LRIADTLYHG SIPNMILSNV DYLVESISSR 120
  121 LNSGMTERVS QILMVICQLA GYETIENFKD VIETIFKLLD YYHGYSDLCL QFFQLFKIII 180
  181 LEMKKKYIND DEMILKIANQ HISQSTFSPW GMTDFQQVLN ILDKETQVKD DITDENDVDF 240
  241 LKDDNEPSNF QEYFDSKLRE PDSDDDEEER EEEVEGSSKE YTDQWTSPIP SDSYKILLQI 300
  301 LGYGERLLTH PSKRLRVQIL IVMRLIFPLL STQHNLLIRE VASTWDSIIQ CVLCSDYSIV 360
  361 QPACSCVEQM IKYSGDFVAK RFIELWQKLC QDSFILKELR IDPTVHNHEK KSISKHVKFP 420
  421

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [975-1038]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVTENALVSM VHMVLEGVKI TEYLISEAVL EQIIYCCIQV VPVEKISSMS LIVGDIVWKI  60
   61 RNIN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: