YRC Public Data Repository - Protein Structure Prediction

Protein:	TTI1
Organism:	Saccharomyces cerevisiae
Length:	1038 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TTI1.

Description	E-value	Query Range	Subject Range
TTI1_YEAST - TEL2-interacting protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TTI1 PE=1 SV=... TTI1 - Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin re...	0.0	[1..1038]	[1..1038]
SPCC622.13c - conserved eukaryotic protein TTI1_SCHPO - TEL2-interacting protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=tti1 PE=1 SV=1	0.0	[44..987]	[48..979]
CG16908-PA - This gene is referred to in FlyBase by the symbol Dmel\CG16908 (CG16908, FBgn0037741). It is a prote...	0.0	[82..937]	[65..953]
K406_MOUSE, K040... - (Q91V83) Protein KIAA0406, Uncharacterized protein KIAA0406 homolog OS=Mus musculus PE=1 SV=1	0.0	[7..394]	[10..383]
gi\|6634031 - gi\|6634031\|dbj\|BAA23702.2\| KIAA0406 protein [Homo sapiens]	0.0	[7..394]	[16..389]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[7..394]	[10..383]
gi\|37537110, gi\|... - gi\|37537110\|ref\|NP_922857.1\| hypothetical protein [Oryza sativa (japonica cultivar-group)], gi\|31433...	3.0E-95	[598..936]	[799..1146]

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Predicted Domain #1

Region A:
Residues: [1-173]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSDTNAFKD IRISCVELSR IAFLPTESFD PNSLTLLACL KKVEEKLSAY EDDSLSPKFA  60
   61 DYVFVPIASL LKQPALGESQ TEYVLLIIFH LLRTCWSSNG KFSEQLGQQL FPLITFLVSS 120
  121 DKDNQKLITR SDEFKYAGCL VLHQFFKSVR SQRYHKEFFS NSKPNLLPAL GHS

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.84
Match:	1i7wC
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [174-282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTILLKILEQ SPQNNELQFK ALASLEVLFQ DIISDGEMLS FILPGNVSVF AKILTKPGRQ  60
   61 IHYKVCVRTL EVLAKLLVLV YDDFSLDIKV NKLTDIRELS DTKLKHEIN

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.84
Match:	1i7wC
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.96084803796407	bayes_pls_golite062009
nucleic acid binding	2.2915564382469	bayes_pls_golite062009
transcription regulator activity	1.78626120336243	bayes_pls_golite062009
structural molecule activity	1.66038601649515	bayes_pls_golite062009
DNA binding	1.62962293446832	bayes_pls_golite062009
protein binding	1.61131270705552	bayes_pls_golite062009
transcription factor activity	0.931585995872658	bayes_pls_golite062009
translation regulator activity	0.642878560112121	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.620348955429476	bayes_pls_golite062009
translation initiation factor activity	0.594620724124658	bayes_pls_golite062009
RNA binding	0.243875756041061	bayes_pls_golite062009
protein kinase activity	0.0590061807192209	bayes_pls_golite062009
cytoskeletal protein binding	0.00858493919409042	bayes_pls_golite062009
transcription activator activity	0.005251231402011	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [283-389]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSFMFNGPIV LLRTDGKTHR DTSWLTATSG QINIALEAFI PKLLKRNNES IDEALATFVS  60
   61 ILLTRCENSL NNCEKVLVST LVHLERDPMS KLPSHLVKLK EVVNEDL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.84
Match:	1i7wC
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [390-431]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKLSDIIRFE NADRLSSLSF AITILEKNNE RDTMINEVVR CL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.84
Match:	1i7wC
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [432-554]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FESLNESIEP PSLINHKERI IEQSSQLTTT VNFENLESTN ALIALPRLSE DMSLKLKKFT  60
   61 YHMGSLLLER HILNDVVTEL ISEQVDSPRT QKIVALWLST NFIKAMEKQP KEEEVYLQFE 120
  121 SDA

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.84
Match:	1i7wC
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [555-974]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYSSSMVEEV CLIVLEFCNE LSQDISMEIE GKGIKKSDEF AVCTVLFSIE TICAVMREEF  60
   61 QPELIDYIYT VVDALASPSE AIRYVSQSCA LRIADTLYHG SIPNMILSNV DYLVESISSR 120
  121 LNSGMTERVS QILMVICQLA GYETIENFKD VIETIFKLLD YYHGYSDLCL QFFQLFKIII 180
  181 LEMKKKYIND DEMILKIANQ HISQSTFSPW GMTDFQQVLN ILDKETQVKD DITDENDVDF 240
  241 LKDDNEPSNF QEYFDSKLRE PDSDDDEEER EEEVEGSSKE YTDQWTSPIP SDSYKILLQI 300
  301 LGYGERLLTH PSKRLRVQIL IVMRLIFPLL STQHNLLIRE VASTWDSIIQ CVLCSDYSIV 360
  361 QPACSCVEQM IKYSGDFVAK RFIELWQKLC QDSFILKELR IDPTVHNHEK KSISKHVKFP 420
  421

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [975-1038]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVTENALVSM VHMVLEGVKI TEYLISEAVL EQIIYCCIQV VPVEKISSMS LIVGDIVWKI  60
   61 RNIN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.693	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.718	a.4.1	Homeodomain-like
View	Download	0.785	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.669	a.112.1	Description not found.
View	Download	0.665	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.660	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.655	a.17.1	p8-MTCP1
View	Download	0.650	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.625	a.4.1	Homeodomain-like
View	Download	0.621	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.594	a.112.1	Description not found.
View	Download	0.590	a.159.2	FF domain
View	Download	0.554	a.4.9	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View	Download	0.543	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.539	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.537	a.8.1	Bacterial immunoglobulin/albumin-binding domains
View	Download	0.530	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.525	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.515	a.13.1	alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View	Download	0.508	a.4.1	Homeodomain-like
View	Download	0.505	a.64.1	Saposin
View	Download	0.495	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.485	a.28.3	Retrovirus capsid protein C-terminal domain
View	Download	0.484	a.179.1	Replisome organizer (g39p helicase loader/inhibitor protein)
View	Download	0.462	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.446	a.12.1	Kix domain of CBP (creb binding protein)
View	Download	0.444	a.64.1	Saposin
View	Download	0.443	a.2.9	C-terminal UvrC-binding domain of UvrB
View	Download	0.441	a.64.2	Bacteriocin AS-48
View	Download	0.438	a.5.1	DNA helicase RuvA subunit, C-terminal domain
View	Download	0.426	a.4.7	Ribosomal protein L11, C-terminal domain
View	Download	0.424	a.56.1	CO dehydrogenase ISP C-domain like
View	Download	0.417	a.44.1	Disulphide-bond formation facilitator (DSBA), insertion domain
View	Download	0.415	a.4.1	Homeodomain-like
View	Download	0.413	a.74.1	Cyclin-like
View	Download	0.413	a.46.1	Methionine synthase domain
View	Download	0.411	a.163.1	Crustacean CHH/MIH/GIH neurohormone
View	Download	0.406	a.4.7	Ribosomal protein L11, C-terminal domain
View	Download	0.400	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.394	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.393	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.391	a.65.1	Annexin
View	Download	0.386	a.57.1	Protein HNS-dependent expression A; HdeA
View	Download	0.384	a.126.1	Serum albumin-like
View	Download	0.383	a.4.1	Homeodomain-like
View	Download	0.383	a.4.1	Homeodomain-like
View	Download	0.381	d.39.1	Dynein light chain 8 (DLC8)
View	Download	0.377	a.4.1	Homeodomain-like
View	Download	0.377	a.17.1	p8-MTCP1
View	Download	0.376	a.144.1	PABC (PABP) domain
View	Download	0.375	a.28.3	Retrovirus capsid protein C-terminal domain
View	Download	0.369	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.369	a.2.8	Eukaryotic DNA topoisomerase I, dispensable insert domain
View	Download	0.361	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.360	a.5.7	4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View	Download	0.358	a.4.7	Ribosomal protein L11, C-terminal domain
View	Download	0.352	a.65.1	Annexin
View	Download	0.349	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.349	a.65.1	Annexin
View	Download	0.348	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.347	a.164.1	C-terminal domain of DFF45/ICAD (DFF-C domain)
View	Download	0.344	a.5.1	DNA helicase RuvA subunit, C-terminal domain
View	Download	0.343	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.338	a.30.1	ROP protein
View	Download	0.338	d.29.1	Ribosomal protein L31e
View	Download	0.336	a.71.1	Endoplasmic reticulum protein ERP29, C-domain
View	Download	0.336	a.64.2	Bacteriocin AS-48
View	Download	0.335	a.126.1	Serum albumin-like
View	Download	0.331	a.5.2	UBA-like
View	Download	0.329	a.2.7	tRNA-binding arm
View	Download	0.329	a.108.1	Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View	Download	0.327	a.108.1	Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View	Download	0.325	a.101.1	Uteroglobin-like
View	Download	0.322	a.101.1	Uteroglobin-like
View	Download	0.322	d.58.24	CheY-binding domain of CheA
View	Download	0.320	f.17.1	F1F0 ATP synthase subunit C
View	Download	0.309	a.23.5	Hemolysin expression modulating protein HHA
View	Download	0.304	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.304	a.3.1	Cytochrome c
View	Download	0.302	a.4.13	Sigma3 and sigma4 domains of RNA polymerase sigma factors
View	Download	0.300	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.299	f.13.1	Family A G protein-coupled receptor-like
View	Download	0.297	a.65.1	Annexin
View	Download	0.295	a.4.9	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View	Download	0.291	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.291	a.157.1	Skp1 dimerisation domain-like
View	Download	0.290	a.30.2	Homodimeric domain of signal transducing histidine kinase
View	Download	0.287	d.74.2	C-terminal domain of arginine repressor
View	Download	0.287	d.52.3	Prokaryotic type KH domain (KH-domain type II)
View	Download	0.286	a.65.1	Annexin
View	Download	0.284	a.21.1	HMG-box
View	Download	0.283	a.60.11	Hypothetical protein YjbJ
View	Download	0.282	a.4.1	Homeodomain-like
View	Download	0.282	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.281	a.3.1	Cytochrome c
View	Download	0.278	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.271	a.144.2	Ribosomal protein L20
View	Download	0.270	a.46.2	Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View	Download	0.268	g.2.2	Neurotoxin B-IV
View	Download	0.266	a.23.5	Hemolysin expression modulating protein HHA
View	Download	0.263	a.138.1	Multiheme cytochromes
View	Download	0.259	a.5.7	4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View	Download	0.258	a.64.2	Bacteriocin AS-48
View	Download	0.257	a.65.1	Annexin
View	Download	0.255	a.163.1	Crustacean CHH/MIH/GIH neurohormone
View	Download	0.255	a.108.1	Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View	Download	0.254	a.46.1	Methionine synthase domain
View	Download	0.251	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.251	a.61.1	Retroviral matrix proteins
View	Download	0.250	a.64.1	Saposin
View	Download	0.248	a.2.3	Chaperone J-domain
View	Download	0.247	d.49.1	Signal recognition particle alu RNA binding heterodimer, SRP9/14
View	Download	0.246	a.5.1	DNA helicase RuvA subunit, C-terminal domain
View	Download	0.245	a.108.1	Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View	Download	0.241	d.169.1	C-type lectin-like
View	Download	0.241	d.58.11	EF-G/eEF-2 domains III and V
View	Download	0.240	a.64.1	Saposin
View	Download	0.240	d.95.2	Homing endonucleases
View	Download	0.238	a.64.1	Saposin
View	Download	0.235	a.28.3	Retrovirus capsid protein C-terminal domain
View	Download	0.235	a.58.1	Chemotaxis receptor methyltransferase CheR, N-terminal domain
View	Download	0.233	a.5.1	DNA helicase RuvA subunit, C-terminal domain
View	Download	0.230	a.37.1	A DNA-binding domain in eukaryotic transcription factors
View	Download	0.230	a.140.2	SAP domain
View	Download	0.227	a.39.1	EF-hand
View	Download	0.225	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View	Download	0.224	a.12.1	Kix domain of CBP (creb binding protein)
View	Download	0.223	a.39.1	EF-hand
View	Download	0.222	a.4.1	Homeodomain-like
View	Download	0.222	a.16.1	S15/NS1 RNA-binding domain
View	Download	0.215	a.4.1	Homeodomain-like
View	Download	0.214	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View	Download	0.212	a.39.1	EF-hand
View	Download	0.209	a.105.1	FIS-like
View	Download	0.209	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.208	a.65.1	Annexin
View	Download	0.207	a.13.1	alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View	Download	0.205	a.181.1	Antibiotic binding domain of TipA-like multidrug resistance regulators
View	Download	0.204	a.156.1	S13-like H2TH domain
View	Download	0.202	a.3.1	Cytochrome c

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: