Protein Overview: TAH11

General Information:
Name(s) found:	TAH11 / YJR046W [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	DNA replication licensing factor, required for pre-replication complex assembly [SGD]
Organism:	Saccharomyces cerevisiae
Length:	604 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] pre-replicative complex [IMP] cytoplasm [IDA]
Biological Process:	regulation of DNA replication initiation [IDA]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGTANSRRK EVLRVPVIDL NRVSDEEQLL PVVRAILLQH DTFLLKNYAN KAVLDALLAG  60
   61 LTTKDLPDTS QGFDANFTGT LPLEDDVWLE QYIFDTDPQL RFDRKCRNES LCSIYSRLFK 120
  121 LGLFFAQLCV KSVVSSAELQ DCISTSHYAT KLTRYFNDNG STHDGADAGA TVLPTGDDFQ 180
  181 YLFERDYVTF LPTGVLTIFP CAKAIRYKPS TMATTDNSWV SIDEPDCLLF HTGTLLARWS 240
  241 QGMHTTSPLQ IDPRANIVSL TIWPPLTTPI SSKGEGTIAN HLLEQQIKAF PKVAQQYYPR 300
  301 ELSILRLQDA MKFVKELFTV CETVLSLNAL SRSTGVPPEL HVLLPQISSM MKRKIVQDDI 360
  361 LKLLTIWSDA YVVELNSRGE LTMNLPKRDN LTTLTNKSRT LAFVERAESW YQQVIASKDE 420
  421 IMTDVPAFKI NKRRSSSNSK TVLSSKVQTK SSNANALNNS RYLANSKENF MYKEKMPDSQ 480
  481 ANLMDRLRER ERRSAALLSQ RQKRYQQFLA MKMTQVFDIL FSLTRGQPYT ETYLSSLIVD 540
  541 SLQDSNNPIG TKEASEILAG LQGILPMDIS VHQVDGGLKV YRWNSLDKNR FSKLLQIHKS 600
  601 KQQD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	TAH11	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..604]	deduced	N/A	No confident structure predictions are available.
2	View Details	[332..457]	FFAS03	1.44	Strucure of Geminin-Cdt1 complex
3	View Details	[458..604]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
DNA binding	2.33472544234344	bayes_pls_golite062009
damaged DNA binding	2.29845214826196	bayes_pls_golite062009
nucleic acid binding	2.22897758853097	bayes_pls_golite062009
binding	1.98369242373199	bayes_pls_golite062009
catalytic activity	0.870891682911347	bayes_pls_golite062009
exonuclease activity	0.690474252448043	bayes_pls_golite062009
protein binding	0.318595689949854	bayes_pls_golite062009

2

Term	Confidence	Notes
transcription regulator activity	4.98098149944065	bayes_pls_golite062009
DNA binding	4.60314587965928	bayes_pls_golite062009
nucleic acid binding	4.41560500044233	bayes_pls_golite062009
transcription factor activity	3.83751005834021	bayes_pls_golite062009
binding	3.37660003833383	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.84400558797599	bayes_pls_golite062009
sequence-specific DNA binding	2.21432668306508	bayes_pls_golite062009
transcription activator activity	2.05647866476552	bayes_pls_golite062009
transcription repressor activity	1.93634276716466	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.28362954833504	bayes_pls_golite062009
structure-specific DNA binding	0.815066484495067	bayes_pls_golite062009
transcription factor binding	0.732240481554495	bayes_pls_golite062009
protein binding	0.726445167461826	bayes_pls_golite062009
nucleotidyltransferase activity	0.437617796040738	bayes_pls_golite062009
ligase activity	0.11359254431153	bayes_pls_golite062009

3

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle