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Protein Overview: IRC8

General Information:
Name(s) found: IRC8 / YJL051W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 822 amino acids

    Gene Ontology:
    Cellular Component: cellular bud [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCHNSVRSGN KAGFLGIKFG SALLSIATGA IAIALLCKFH DHEAVLIVIV CSTLLYGIPS  60
   61 LISFITETVF APSKFHIGYF YNVLNFALPL ITMGCTVDYF HNTLRSPISV QSESHRVYIT 120
  121 TLDSLLIFTL FINGIQLGFF LKDGNANNFG SSSNNISTDQ YDKEANAVEN GRFVPLKNSS 180
  181 QTLTPDLELL HGSPKSMNGV AWLINELSTN SNTNANKTIS SDENSNSSVI RHKLGPISTS 240
  241 KCPKKPSHSH FSKLKKYNSF FLGPKENRYK RNTQQATKVP TEKKSNHRSS QYVSRLSTIS 300
  301 DISKSFLNFL ALNEKNGNST STARTPSEGR VSIIINEGNN TLKYKTPHDS HTIDSPNLEL 360
  361 EREAIGRINS ALLPACLRVT DKMISPQQST QNEDSYQATP LIPQVEVDDD FYVGDILMTN 420
  421 ELQDIPQVPR ISSDIEDDFE QQYTKHVDLP ARVTLEMWEK DQEKILQKVT TNRDKSKLLP 480
  481 PFRFTSESDM DPSTSTELEV ELHAQNNFSF PFKSAGLQIA TSDQFNQQEF KTSDTISELD 540
  541 EYLHDPSIQE EDASQLIESS LNQNNLSSTT IDNGPKDMSR FSTRHSPTKS IISMISGSGS 600
  601 VKHQHSHSTL SNFFTGHSRN NSQINQLLQG SSSNMMSNTS PHSSPTKSLR MRFGKKLSLS 660
  661 NISDTMSPYE GSTTDPINYS FGHGHNKNQS IDFSYVRTLQ SSHSPTKSTS GNSRRDSLNN 720
  721 DRTQSTVNER ALRTASTLFY LQHNNATCTL NGEEPVLDTP QSIQSSSSGS EQESAGSGSG 780
  781 YPEVVFSEYD REKWNVLRNL KEIAPEKTIE SGPVEELVSP SK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) IRC8 LSM12 RPL38 YLL032C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..154] deduced N/A No confident structure predictions are available.
    2 View Details [155..691] MSA 6.038997 View MSA. No confident structure predictions are available.
    3 View Details [692..822] MSA 1.014984 View MSA. No confident structure predictions are available.
    4 View Details [480..548] deduced N/A No confident structure predictions are available.
    5 View Details [549..678] MSA 1.11399 View MSA. No confident structure predictions are available.
    6 View Details [679..822] MSA 1.047983 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  0.916346296983561 bayes_pls_golite062009
  • binding
    		•  0.67385346756555 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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