Protein Overview: AIM21

General Information:
Name(s) found:	AIM21 / YIR003W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731906\|sp\|P40563.1\|YIS3_YEAST RecName: Full=Uncharacterized protein YIR003W [NCBI NR] gi\|6322193\|ref\|NP_012268.1\| Protein of unknown function; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton; null mutant displays increased frequency of mitochondrial genome loss (petite formation); Aim21p [Sa [NCBI NR] pir\|\|S48437 hypothetical protein YIR003w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|557852\|emb\|CAA86205.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Uncharacterized protein YIR003W OS=Saccharomyces cerevisiae GN=YIR003W PE=1 SV=1 [Swiss-Prot] Protein of unknown function localised to actin cytoskeleton [mips] Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton [SGD] YIR003W, Chr IX from 360882-362921 [yeast_orfs2] Chr IX from 360882-362921 [yeastorf3.fasta] (P40563) Hypothetical 74.8 kDa protein in BET1-PAN1 intergenic region [4932.FASTACCERV.txt] YIR003W SGDID:S0001442, Chr IX from 360882-362921, Uncharacterized ORF [yeastflysequest.fasta] Yir003wp [Saccharomyces cerevisiae]gi\|557852\|emb\|CAA86205.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|731906\|sp\|P40563\|YIS3_YEAST Hypothetical 74.8 kDa protein in BET1-PAN1 intergenic regiongi\|626349\|pir\|\|S48437 hypothetical protein YIR003w [nrdb_11152004_Chlamydomonas] YIR003W SGDID:S000001442, Chr IX from 360882-362921, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YIR003W SGDID:S000001442, Chr IX from 360882-362921, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with Sac1p to the actin cytoskeleton; interacts with the SH3 domain of the actin bi [yeast-contam.fasta] YIR003W SGDID:S000001442, Chr IX from 360882-362921, Verified ORF, "Protein of unknown function; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton; null mutant displays increased frequency of mitochondrial ge [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] YIR003W SGDID:S000001442, Chr IX from 360882-362921, Verified ORF, "Protein of unknown function; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton; YIR003W is not an essential gene" [yeast-200209-contam.fasta] AIM21 SGDID:S000001442, Chr IX from 360882-362921, Verified ORF, "Protein of unknown function; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton; YIR003W is not an essential gene; null mutant displays elevate [SGD_S-cerevisiae_na_05-08-2009_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Uncharacterized protein YIR003W [nr-271106-contam.fasta] Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with Sac1p to the actin cytoskeleton; interacts with the SH3 domain of the actin binding protein Abp1p; YIR003W is a non-essential gene; Yir003wp [Saccharomyc [nr-271106-contam.fasta] AIM21 SGDID:S000001442, Chr IX from 360882-362921, Verified ORF, "Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] AIM21 SGDID:S000001442, Chr IX from 360882-362921, Verified ORF, "Protein of unknown function; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton; YIR003W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss" [scerevisihumanrev.fasta] YIR003W SGDID:S000001442, Chr IX from 360882-362921, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with Sac1p to the actin cytoskeleton; interacts with the SH3 domain of the actin binding protein Abp1p; YIR003W is a non-essential gene" [yeast-contam_custom.fasta] [chemostatdb.fasta] AIM21 SGDID:S000001442, Chr IX from 360885-362924, Genome Release 64-1-1, Verified ORF, "Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton" [yeast-030211-contam.fasta] AIM21 SGDID:S000001442, Chr IX from 360885-362924, Genome Release 64-2-1, Verified ORF, "Protein of unknown function; involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton" [20141208_orf_trans.fasta] YIR003W SGDID:S000001442, Chr IX from 360885-362924, Genome Release 64-1-1, Verified ORF, "Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	679 amino acids
Gene Ontology:
Cellular Component:	actin cytoskeleton [IDA] ribosome [IDA]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSEVTPKVP ERPSRRKTSE LFPLSGSESG DIKANSEPPT PAGTPNVPTR RPILKAKTMT  60
   61 SFESGMDQES LPKVPLQRPV RRSTTEELNN VMNNTSKELE EIESLISKHN IHNVSRKKSP 120
  121 TSVEEGKVAA IHQNGQRSAS DNKTSTNPSP LEKNEHEGAE GNESAISPSN LVNKSNNEVT 180
  181 EHSDSEDLTE KQKVHAALDN EAGDRSHFEE KLIPGDMKVQ VDVSKDVEEG SLNALPPSGI 240
  241 TESDDKAEKF TKHPESSLEE LQKHQEQQEE KIFQNPTDEE STTSLNEKQE GKDNMEVNSQ 300
  301 PQGPSDTETV IAATSSNVPS QIASEEENDV PVIPRSRPKK DFEAHVQKEE LPNTQEKRVS 360
  361 EECDSTLIST EEESKIPKIP SERPKRRAPP PVPKKPSSRI AAFQEMLQKQ QQQDLHNNGN 420
  421 SSATTASADI AKKHTDSSIT SDTTKADFTS KLNGLFALPG MVNPGQLPPS LEKKLSSPDT 480
  481 ESKLGPQDQS QAKTGPLGGT RRGRGPRGRK LPSKVASVEK IEEDDNTNKI EIFNNWNVSS 540
  541 SFSKEKVLID TTPGEQAERA LDEKSKSIPE EQREQSPNKM EAALCPFELD EKEKLPANAE 600
  601 SDPLSQLPQT NAVGNRKAIS EESLSPSEAI ANRDQNDTTE IQEQQMEDQM EVDMERELSG 660
  661 GYEDVDSALH SEEASFHSL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		AIM21 CAP2 TDA2
View Details	Krogan NJ, et al. (2006)		AIM21 TDA2
View Details	Gavin AC, et al. (2006)		AIM21 CAP1 CAP2 TDA2
View Details	Gavin AC, et al. (2002)		AIM21 CAP1 CAP2 TDA2
View Details	Ho Y, et al. (2002)		ADH2 AIM21 BUD20 CIC1 COF1 CPR1 EHD3 GPI15 HHF1, HHF2 HMO1 HTB1 HTB2 HYP2 LSM2 MAM33 MDH1 MGM101 MRPS16 OYE2 RLP24 TEF4 UTP20 YFL006W
View Details	Qiu et al. (2008)		ABP1 AIM21 AIP1 CRN1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MPC54	AIM21	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	AIM21	Huh WK, et al. (2003)
View Data	AIM21 and SAC6	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..17] [242..320]	ORFEUS	13.0	No description for 1l8mA was found.
2	View Details	[18..90]	ORFEUS	13.0	No description for 1l8mA was found.
3	View Details	[91..169]	ORFEUS	13.0	No description for 1l8mA was found.
4	View Details	[170..241]	ORFEUS	13.0	No description for 1l8mA was found.
5	View Details	[321..503]	ORFEUS	7.9	Calnexin
6	View Details	[504..591]	ORFEUS	13.75	Sec24
7	View Details	[592..679]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2