Protein Overview: PCL7

General Information:
Name(s) found:	PCL7 / YIL050W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731808\|sp\|P40186.3\|PCL7_YEAST RecName: Full=PHO85 cyclin-7; AltName: Full=PHO85-associated protein 1 [NCBI NR] gi\|6322139\|ref\|NP_012214.1\| Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; Pcl7p [Saccharomyc [NCBI NR] pir\|\|S48429 probable membrane protein YIL050w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|557818\|emb\|CAA86172.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] (P40186) Uncharacterized protein YIL050W [Swiss-Prot] PHO85 cyclin-7 OS=Saccharomyces cerevisiae GN=PCL7 PE=1 SV=3 [Swiss-Prot] PCL7 Cyclin like protein interacting with Pho85p [mips] Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated [SGD] PCL7, Chr IX from 258912-259769 [yeast_orfs2] Chr IX from 258912-259769 [yeastorf3.fasta] (P40186) Hypothetical 32.0 kDa protein in RPL34B-SYG1 intergenic region [4932.FASTACCERV.txt] PCL7 SGDID:S0001312, Chr IX from 258912-259769, Verified ORF [yeastflysequest.fasta] Pcl7p [Saccharomyces cerevisiae]gi\|557818\|emb\|CAA86172.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|731808\|sp\|P40186\|YIF0_YEAST Hypothetical 32.0 kDa protein in RPL34B-SYG1 intergenic regiongi\|626342\|pir\|\|S48429 probable membrane protein YIL [nrdb_11152004_Chlamydomonas] PCL7 SGDID:S000001312, Chr IX from 258912-259769, Verified ORF, "Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cel [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Uncharacterized protein YIL050W [nr-271106-contam.fasta] Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; Pcl7p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] PCL7 SGDID:S000001312, Chr IX from 258912-259769, Verified ORF, "Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated" [yeast-bovrabprots.fasta] [chemostatdb.fasta] PHO85 cyclin-7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PCL7 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PCL7 SGDID:S000001312, Chr IX from 258913-259770, Genome Release 64-1-1, Verified ORF, "Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated" [yeast-030211-contam.fasta] PCL7 SGDID:S000001312, Chr IX from 258913-259770, Genome Release 64-2-1, Verified ORF, "Pho85p cyclin of the Pho80p subfamily; forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; PCL7 has a paralog, PCL6, that arose from the whole genome duplication" [20141208_orf_trans.fasta] TR5748\|c0_g1_i1\|g.3958 ORF TR5748\|c0_g1_i1\|g.3958 TR5748\|c0_g1_i1\|m.3958 type:complete len:286 (+) TR5748\|c0_g1_i1:365-1222(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YIL050W SGDID:S000001312, Chr IX from 258913-259770, Genome Release 64-1-1, Verified ORF, "Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_8931\|g.6540 ORF asmbl_8931\|g.6540 asmbl_8931\|m.6540 type:complete len:286 (+) asmbl_8931:439-1296(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	285 amino acids
Gene Ontology:
Cellular Component:	cyclin-dependent protein kinase holoenzyme complex [TAS]
Biological Process:	regulation of glycogen biosynthetic process [IGI] regulation of glycogen catabolic process [IGI]
Molecular Function:	cyclin-dependent protein kinase regulator activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELSSPSKKT TTSPINIPGG NRDNLIIGPH SHSFKTDPFS SNNSSLLSKI STNPSLESPF  60
   61 SSKSLLDCSP VQAVKKSLES EAKTHSLDEE TNEQTDVKIL NIADFPTDEL ILMISALLNR 120
  121 IITANDETTD VSQQVSDETE DELLTPILAF YGKNVPEIAV VQYLERIQKY CPTTNDIFLS 180
  181 LLVYFDRISK NYGHSSERNG CAKQLFVMDS GNIHRLLITG VTICTKFLSD FFYSNSRYAK 240
  241 VGGISLQELN HLELQFLILC DFKLLVSVEE MQKYANLLYK FWNDQ

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		PCL7 PHO85
View Details	Krogan NJ, et al. (2006)		MTQ2 PCL7 TYW3
View Details	Ho Y, et al. (2002)		ADK1 AGX1 PCL7 PHO81 PHO85 YHB1
View Details	Qiu et al. (2008)		PCL10 PCL6 PCL7 PCL8 PHO80

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC28	PCL7	2	Unpublished Fields Lab Data
View Screen	PHO85	PCL7	2	Uetz P, et al. (2000)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	PCL7	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..285]	MSA	21.049978	View MSA. No confident structure predictions are available.
2	View Details	[78..285]	FFAS03	3.02	The structural basis of CDK2 activation by cyclin E

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
cyclin-dependent protein kinase regulator activity	5.56043783950774	bayes_pls_golite062009
cyclin-dependent protein kinase activity	3.56449795345173	bayes_pls_golite062009
protein kinase regulator activity	2.42298912398512	bayes_pls_golite062009
kinase regulator activity	2.38269740782712	bayes_pls_golite062009
binding	2.37916921859542	bayes_pls_golite062009
transcription regulator activity	2.35246308363499	bayes_pls_golite062009
nucleic acid binding	1.66282585660189	bayes_pls_golite062009
DNA binding	1.62111826122916	bayes_pls_golite062009
protein binding	1.37207701115974	bayes_pls_golite062009
transcription factor activity	0.942934833538458	bayes_pls_golite062009
protein kinase activity	0.936843200737436	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.790804751794544	bayes_pls_golite062009
kinase activity	0.76336575273867	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.681773164635831	bayes_pls_golite062009
hydrolase activity	0.639492478283697	bayes_pls_golite062009
transcription factor binding	0.578625558009429	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.553775750179295	bayes_pls_golite062009
protein serine/threonine kinase activity	0.529818399573297	bayes_pls_golite062009
enzyme regulator activity	0.461517963237846	bayes_pls_golite062009
kinase binding	0.288717702650258	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.0259350481945262	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2