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Protein Overview: PHO80

General Information:
Name(s) found: PHO80 / YOL001W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 293 amino acids

    Gene Ontology:
    Cellular Component: cyclin-dependent protein kinase holoenzyme complex [TASLink to PubMed article]
    Biological Process: regulation of phosphate metabolic process [TASLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    Molecular Function: cyclin-dependent protein kinase regulator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESTSGERSE NIHEDQGIPK VILPADFNKC SRTDLVVLIS RMLVSLIAIN ENSATKKSDD  60
   61 QITLTRYHSK IPPNISIFNY FIRLTKFSSL EHCVLMTSLY YIDLLQTVYP DFTLNSLTAH 120
  121 RFLLTATTVA TKGLCDSFST NAHYAKVGGV RCHELNILEN DFLKRVNYRI IPRDHNITLC 180
  181 SIEQKQKKFV IDKNALGSLD LDSYSYVNRP KSGYNVLDKY YRRIVQLVGS FNASPDKSRK 240
  241 VDYVLPPNID IVSESGSQTT QLKGSSSPNS HSSQKRYSEA KDAHIYNKRS KPD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PHO80 PHO81 PHO85
    View Details (MIPS) Mewes HW, et al. (2004) PCL1 PCL10 PCL2 PCL8 PHO80 PHO85
    View Details Krogan NJ, et al. (2006) PHO80 PHO81
    View Details Qiu et al. (2008) CLG1 PCL1 PCL10 PCL2 PCL5 PCL6 PCL7 PCL8 PHO80

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ROM2 PHO80 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PHO80 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..209] PSI-BLAST 32.522879 Cyclin A
    2 View Details [210..293] MSA 1.032972 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cyclin-dependent protein kinase regulator activity
    		•  6.12919068656167 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  3.81462270101479 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  2.90083336559452 bayes_pls_golite062009
  • kinase regulator activity
    		•  2.84789294954357 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.795846725429 bayes_pls_golite062009
  • binding
    		•  2.4204867358489 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.04886889839181 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.00665312545368 bayes_pls_golite062009
  • DNA binding
    		•  1.94297811210385 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.86347643875964 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.65951279073909 bayes_pls_golite062009
  • protein binding
    		•  1.47106731485576 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.42956126861466 bayes_pls_golite062009
  • transcription factor activity
    		•  1.21921365719206 bayes_pls_golite062009
  • protein kinase activity
    		•  0.957590284872001 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.806564872314381 bayes_pls_golite062009
  • kinase activity
    		•  0.79567569649664 bayes_pls_golite062009
  • transcription factor binding
    		•  0.749278791251235 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.567809158275482 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.561985718866596 bayes_pls_golite062009
  • kinase binding
    		•  0.451409627821468 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0696060248241566 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle