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Protein Overview: PCL1

General Information:
Name(s) found: PCL1 / YNL289W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 279 amino acids

    Gene Ontology:
    Cellular Component: cyclin-dependent protein kinase holoenzyme complex [TASLink to PubMed article]
    Biological Process: cell cycle [TASLink to PubMed article]
    Molecular Function: cyclin-dependent protein kinase regulator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCEYSKALHI LLKSPVTDDI IKFLTDTTLR VVPSSNYPTP PGSPGEKHLT RLPSLMTFIT  60
   61 RLVRYTNVYT PTLLTAACYL NKLKRILPRD ATGLPSTIHR IFLACLILSA KFHNDSSPLN 120
  121 KHWARYTDGL FTLEDINLME RQLLQLLNWD LRVNTEDLIL DLQPLLEPIK QDLARSSDQR 180
  181 KRINMMMSMN RRTCAGTSPI RSNNRFKLYE KQRNVSIASD LSSATLVDSC NDLRRLKDVT 240
  241 NIANNTVANT NYVRTVEKWN DNVNRQSWDL EQIMSQHGF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) PCL1 PCL10 PCL2 PCL8 PHO80 PHO85
    View Details Qiu et al. (2008) CLG1 PCL1 PCL5 PHO80

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..26]
    [156..279]    		 PSI-BLAST 57.154902 Cyclin A
    2 View Details [27..155] PSI-BLAST 57.154902 Cyclin A


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle