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View Structure Prediction Details

Protein: PCL7
Organism: Saccharomyces cerevisiae
Length: 285 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PCL7.

Description E-value Query
Range
Subject
Range
PCL7 - Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphory...
PCL7_YEAST - PHO85 cyclin-7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PCL7 PE=1 SV=3
1.0E-78 [1..285] [1..285]
gi|15451434 - gi|15451434|dbj|BAB64521.1| hypothetical protein [Macaca fascicularis]
4.0E-60 [48..282] [5..242]
gi|18766395 - gi|18766395|gb|AAL78999.1|AF465729_1 cyclin fold protein 1 variant b [Homo sapiens]
1.0E-56 [4..282] [11..282]
gi|12856757 - gi|12856757|dbj|BAB30772.1| unnamed protein product [Mus musculus]
3.0E-55 [4..282] [11..282]
PREG_NEUCR - Nuc-1 negative regulatory protein preg OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 70...
PREG_NEUCR - Nuc-1 negative regulatory protein preg OS=Neurospora crassa GN=preg PE=1 SV=1
8.0E-48 [19..275] [158..420]

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Predicted Domain #1
Region A:
Residues: [1-285]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELSSPSKKT TTSPINIPGG NRDNLIIGPH SHSFKTDPFS SNNSSLLSKI STNPSLESPF  60
   61 SSKSLLDCSP VQAVKKSLES EAKTHSLDEE TNEQTDVKIL NIADFPTDEL ILMISALLNR 120
  121 IITANDETTD VSQQVSDETE DELLTPILAF YGKNVPEIAV VQYLERIQKY CPTTNDIFLS 180
  181 LLVYFDRISK NYGHSSERNG CAKQLFVMDS GNIHRLLITG VTICTKFLSD FFYSNSRYAK 240
  241 VGGISLQELN HLELQFLILC DFKLLVSVEE MQKYANLLYK FWNDQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [78-285]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LESEAKTHSL DEETNEQTDV KILNIADFPT DELILMISAL LNRIITANDE TTDVSQQVSD  60
   61 ETEDELLTPI LAFYGKNVPE IAVVQYLERI QKYCPTTNDI FLSLLVYFDR ISKNYGHSSE 120
  121 RNGCAKQLFV MDSGNIHRLL ITGVTICTKF LSDFFYSNSR YAKVGGISLQ ELNHLELQFL 180
  181 ILCDFKLLVS VEEMQKYANL LYKFWNDQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.02
Match: 1w98B
Description: The structural basis of CDK2 activation by cyclin E
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclin-dependent protein kinase regulator activity 5.56043783950774 bayes_pls_golite062009
cyclin-dependent protein kinase activity 3.56449795345173 bayes_pls_golite062009
protein kinase regulator activity 2.42298912398512 bayes_pls_golite062009
kinase regulator activity 2.38269740782712 bayes_pls_golite062009
binding 2.37916921859542 bayes_pls_golite062009
transcription regulator activity 2.35246308363499 bayes_pls_golite062009
nucleic acid binding 1.66282585660189 bayes_pls_golite062009
DNA binding 1.62111826122916 bayes_pls_golite062009
protein binding 1.37207701115974 bayes_pls_golite062009
transcription factor activity 0.942934833538458 bayes_pls_golite062009
protein kinase activity 0.936843200737436 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.790804751794544 bayes_pls_golite062009
kinase activity 0.76336575273867 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.681773164635831 bayes_pls_golite062009
hydrolase activity 0.639492478283697 bayes_pls_golite062009
transcription factor binding 0.578625558009429 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.553775750179295 bayes_pls_golite062009
protein serine/threonine kinase activity 0.529818399573297 bayes_pls_golite062009
enzyme regulator activity 0.461517963237846 bayes_pls_golite062009
kinase binding 0.288717702650258 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.0259350481945262 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle