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Protein Overview: CCH1

General Information:
Name(s) found: CCH1 / YGR217W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2039 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: calcium ion transport [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: calcium channel activity [IDALink to PubMed article][IMPLink to PubMed article]
    voltage-gated calcium channel activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQGRKRTLTE PFEPNTNPFG DNAAVMTENV EDNSETDGNR LESKPQALVP PALNIVPPES  60
   61 SIHSTEEKKG DEYNGNDKDS SLISNIFRTR VGRSSHENLS RPKLSLKTAS FGAAESSRRN 120
  121 VSPSTKSAKS SSQYIDLNDE RLRRRSFSSY SRSSSRRVSN SPSSTDRPPR SAKVLSLIAA 180
  181 DDMDDFEDLQ KGFKSAIDEE GLTWLPQLKS EKSRPVSDVG EDRGEGEQES IPDVHTPNVG 240
  241 ASATPGSIHL TPEPAQNGSV SEGLEGSINN SRKKPSPKFF HHLSPQKEDK DQTEVIEYAE 300
  301 DILDFETLQR KLESRPFVLY GHSLGVFSPT NPLRIKIARF LLHRRYSLLY NTLLTFYAIL 360
  361 LAIRTYNPHN VVFLYRFSNW TDYFIFILSA CFTGNDIAKI IAFGFWDDSE MFKAYGREYK 420
  421 SILQRSGIMK LYIYLREKYG RKLIDFIIPF RIISPGEETK YQRSSLSTSL TKPYGAKENQ 480
  481 RPFGTPRAFA RSSWNRIDLV SSVSFWLGMF LSIKSYDTKT GIRIFKPLAI LRILRLVNVD 540
  541 TGMPSILRGL KYGIPQLVNV SSMLVYFWIF FGILGVQIFQ GSFRRQCVWF NPEDPTDTYQ 600
  601 YDMQFCGGYL DPVTKRKQNY IYEDGSEGSV SKGFLCPQYS KCVSNANPYN GRISFDNIVN 660
  661 SMELVFVIMS ANTFTDLMYY TMDSDEMAAC LFFIVCIFVL TIWLLNLLIA VLVSSFEIAN 720
  721 EEYKKKKFIY GSRKTGYVAR IVTGYWKYFK LKANQTKFPN WSQKGLAIYS HVEFIFVILI 780
  781 ICDIGMRASV KVSTSANCNN ILLKTDRGIS IVLFIESLAR LVLYLPNMWK FLTKPSYVYD 840
  841 FIISIITLVI SCLAVEGVLG HMYAWLSIFH ISRFYRVIIS FNLTKKLWKQ ILSNGVMIWN 900
  901 LSSFYFFFTF LVAIIMAVYF EGVIPPEEMA DQPFGMYSLP NSFLSLFIIG STENWTDILY 960
  961 ALQKHSPNIS STFFCSVFFI IWFLLSNSVI LNIFIALISE SMEVKEEEKR PQQIKHYLKF1020
 1021 VYPQKIQEYT HASLVARIRK KFFGGHRNED TRDFKQFLMR GTAIMNIAQN MGELADEFKE1080
 1081 PPSENLFKKG LSKLTIGVPS LKRLRMFANN PFYKNSDVVF TETNDINGRT YILELNEYED1140
 1141 EKLDYLKKYP LFNYSYYFFS PQHRFRRFCQ RLVPPSTGKR TDGSRFFEDS TDLYNKRSYF1200
 1201 HHIERDVFVF IFALATILLI VCSCYVTPLY RMHHKMGTWN WSSALDCAFI GAFSIEFIVK1260
 1261 TVADGFIYSP NAYLRNPWNF IDFCVLISMW INLIAYLKNN GNLSRIFKGL TALRALRCLT1320
 1321 ISNTARQTFN LVMFDGLNKI FEAGLISLSL LFPFTVWGLS IFKGRLGTCN DGSLGRADCY1380
 1381 NEYSNSVFQW DIMSPRVYQQ PYLHLDSFAS AFSSLYQIIS LEGWVDLLEN MMNSSGIGTP1440
 1441 ATVMGSAGNA LFLVLFNFLS MVFILNLFVS FIVNNQARTT GSAYFTIEEK AWLESQKLLS1500
 1501 QAKPKAIPNL IELSRVRQFF YQLAVEKKNF YYASFLQVVL YLHIIMLLSR SYNPGNLIGY1560
 1561 QGVYFMFSTS VFLIQEALHM CGEGPRLYFR QKWNSIRLSI IIIAFIMNAV AFHVPASHYW1620
 1621 FHNIKGFFLL VIFLFIIPQN DTLTELLETA MASLPPILSL TYTWGVLFLV YAIALNQIFG1680
 1681 LTRLGSNTTD NINFRTVIKS MIVLFRCSFG EGWNYIMADL TVSEPYCSSD DNSTYTDCGS1740
 1741 ETYAYLLLMS WNIISMYIFV NMFVSLIIGN FSYVYRSGGS RSGINRSEIK KYIEAWSKFD1800
 1801 TDGTGELELS YLPRIMHSFD GPLSFKIWEG RLTIKSLVEN YMEVNPDDPY DVKIDLIGLN1860
 1861 KELNTIDKAK IIQRKLQYRR FVQSIHYTNA YNGCIRFSDL LLQIPLYTAY SARECLGIDQ1920
 1921 YVHHLYILGK VDKYLENQRN FDVLEMVVTR WKFHCRMKRT IEPEWDVKDP TVSSHISNIN1980
 1981 VNLEPAPGIL EREPIATPRM DYGVNNFMWS PRMNQDSTME PPEEPIDNND DSANDLIDR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HMT1 CCH1 1 Unpublished Fields Lab Data
    View Screen HSH49 CCH1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CCH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..232] deduced N/A No confident structure predictions are available.
    2 View Details [233..365] PSI-BLAST 19.0 KV1.1
    3 View Details [366..426] deduced N/A Confident ab initio structure predictions are available.
    4 View Details [427..611] MSA 4.065986 View MSA. No confident structure predictions are available.
    5 View Details [612..1110] MSA 24.222986 View MSA. No confident structure predictions are available.
    6 View Details [1111..1197] deduced N/A No confident structure predictions are available.
    7 View Details [1198..1330] MSA 2.132996 View MSA. No confident structure predictions are available.
    8 View Details [1331..1437] MSA 7.141995 View MSA. No confident structure predictions are available.
    9 View Details [1438..1528] PSI-BLAST 3.522879 Sodium channel IIA
    10 View Details [1529..1761] MSA 11.213994 View MSA. No confident structure predictions are available.
    11 View Details [1762..1891] MSA 2.175984 View MSA. No confident structure predictions are available.
    12 View Details [1892..2039] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • metal ion transmembrane transporter activity
    		•  4.7372448658795 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  4.63984862452408 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.6123766644348 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  4.56176308768245 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.53708718755887 bayes_pls_golite062009
  • potassium channel activity
    		•  4.51985608289081 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  4.5171803357978 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  4.51256290813453 bayes_pls_golite062009
  • cation channel activity
    		•  4.45938408950249 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.18703661144599 bayes_pls_golite062009
  • gated channel activity
    		•  3.79587174965364 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  3.72917222310854 bayes_pls_golite062009
  • ion channel activity
    		•  3.48521592747971 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  3.39410147300457 bayes_pls_golite062009
  • channel activity
    		•  3.39410147300457 bayes_pls_golite062009
  • transporter activity
    		•  2.77619896060397 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.65613366364107 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.3511225030312 bayes_pls_golite062009
  • inward rectifier potassium channel activity
    		•  2.22500563098935 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  1.95018194128504 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  1.95018194128504 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle