Protein Overview: GTO1

General Information:
Name(s) found:	GTO1 / YGR154C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321593\|ref\|NP_011670.1\| Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization; Gto1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S60444 hypothetical protein YKR076w homolog YGR154c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1351824\|sp\|P48239.1\|GTO1_YEAST RecName: Full=Glutathione S-transferase omega-like 1 [NCBI NR] gi\|1323261\|emb\|CAA97168.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|1045259\|emb\|CAA59811.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Uncharacterized protein YGR154C - Saccharomyces cerevisiae (Baker's yeast) [Swiss-Prot] Glutathione S-transferase omega-like 1 OS=Saccharomyces cerevisiae GN=GTO1 PE=1 SV=1 [Swiss-Prot] GTO1 Putative Omega-class glutathione transferase [mips] Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization [SGD] YGR154C, Chr VII from 796793-797863, reverse complement [yeast_orfs2] Chr VII from 796793-797863, reverse complement [yeastorf3.fasta] Chr VII from 796800-797870, reverse complement [yeastorf4.fasta] Chr VII from 797870-796800, reverse complement [yeastorf5.fasta] (P48239) Hypothetical 41.3 kDa protein in RSR1-CYS4 intergenic region [4932.FASTACCERV.txt] YGR154C SGDID:S0003386, Chr VII from 797871-796801, reverse complement, Uncharacterized ORF [yeastflysequest.fasta] YGR154C SGDID:S0003386, Chr VII from 797873-796803, reverse complement, Uncharacterized ORF [10112005cervSGD.fasta] Ygr154cp [Saccharomyces cerevisiae]gi\|1323261\|emb\|CAA97168.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|1045259\|emb\|CAA59811.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|2131722\|pir\|\|S60444 hypothetical protein YKR076w homolog YGR [nrdb_11152004_Chlamydomonas] YGR154C SGDID:S000003386, Chr VII from 797873-796803, reverse complement, Uncharacterized ORF, "Omega-class glutathione transferase" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] GTO1 SGDID:S000003386, Chr VII from 797873-796803, reverse complement, Uncharacterized ORF, "Putative peroxisomal Omega-class glutathione transferase; induced under oxidative stress" [yeast-contam.fasta] GTO1 SGDID:S000003386, Chr VII from 797873-796803, reverse complement, Verified ORF, "Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Hypothetical 41.3 kDa protein in RSR1-CYS4 intergenic region [nr-271106-contam.fasta] Putative peroxisomal Omega-class glutathione transferase; induced under oxidative stress; Gto1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Glutathione S-transferase omega-like 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GTO1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] GTO1 SGDID:S000003386, Chr VII from 797868-796798, Genome Release 64-1-1, reverse complement, Verified ORF, "Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization" [yeast-030211-contam.fasta] GTO1 SGDID:S000003386, Chr VII from 797868-796798, Genome Release 64-2-1, reverse complement, Verified ORF, "Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization" [20141208_orf_trans.fasta] YGR154C SGDID:S000003386, Chr VII from 797868-796798, Genome Release 64-1-1, reverse complement, Verified ORF, "Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	356 amino acids
Gene Ontology:
Cellular Component:	peroxisome [IDA]
Biological Process:	glutathione metabolic process [ISS]
Molecular Function:	glutathione transferase activity [IDA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVSYKGTIS KTHSVFKPEK GRYYIYGALG CPFTHRAILA RSLKKLEPVL GLVLSHWQLD  60
   61 SKGARFLPAP HRPEKYKERF FTATGGIASA KLDESEELGD VNNDSARLFV DGAFDPVENI 120
  121 SRLSELYYLN DPKYPGTKFT VPVLWDSKTR KIVNNESGDI IRILNSGVFD EFIQSEETNV 180
  181 IDLVPHDLID EIDKNIKWVH PKINLGVYKV GLAENGKIYE TEVKTLFENL QKMECVLKEN 240
  241 YKRLEEQFSG NKQKILAKYF VLGQRLTEAD IRLYPSIIRF DVVYVQHFKC NLKTIRDGFP 300
  301 YLHLWLINLY WNYAEFRFTT DFNHIKLFYI RMEVSRNKIN QFGIVPLGPK PDISRL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		BCY1 CAR2 CYS4 GND1 GTO1 LAA1 LYS1 SAH1 SNO2 SSN8 THI22 THO2 TIF1, TIF2 TPK2 TPK3 VPS21 YBR028C YCK1 YCK2 YCK3 YGR111W YPT53

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	APC5	GTO1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..100]	PSI-BLAST	42.09691	Class omega GST
2	View Details	[101..203]	PSI-BLAST	42.09691	Class omega GST
3	View Details	[204..356]	PSI-BLAST	3.221849	Chloride intracellular channel 1 (clic1)

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
glutathione binding	2.07086805531749	bayes_pls_golite062009
glutathione transferase activity	1.85683051472829	bayes_pls_golite062009
antioxidant activity	1.78836688224506	bayes_pls_golite062009
peroxidase activity	1.62851025934188	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	1.62851025934188	bayes_pls_golite062009
binding	1.1101496519064	bayes_pls_golite062009
glutathione peroxidase activity	1.08052084417939	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.0279404567142	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
peroxiredoxin activity	0.366096607480921	bayes_pls_golite062009
protein binding	0.341730456502484	bayes_pls_golite062009
selenium binding	0.237008126838281	bayes_pls_golite062009
thioredoxin peroxidase activity	0.163136748643487	bayes_pls_golite062009

Term	Confidence	Notes
glutathione transferase activity	3.95712498751783	bayes_pls_golite062009
glutathione binding	3.1027755387739	bayes_pls_golite062009
binding	1.73671487004343	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	1.08486797497934	bayes_pls_golite062009
transferase activity	1.05573069897577	bayes_pls_golite062009
catalytic activity	0.963623964325467	bayes_pls_golite062009
protein binding	0.816387415768278	bayes_pls_golite062009
glutathione peroxidase activity	0.0539815835450801	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.90

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2