Protein Overview: FLC3

General Information:
Name(s) found:	FLC3 / YGL139W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321299\|ref\|NP_011376.1\| Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; Flc3p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S64153 probable membrane protein YGL139w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1723922\|sp\|P53121.1\|FLC3_YEAST RecName: Full=Putative flavin carrier protein 3; AltName: Full=FAD transporter 3; AltName: Full=TRP-like ion channel FLC3; Flags: Precursor [NCBI NR] gi\|1322714\|emb\|CAA96851.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] (P53121) Hypothetical 90.8 kDa protein in HUL5-SEC27 intergenic region [Swiss-Prot] Putative flavin carrier protein 3 OS=Saccharomyces cerevisiae GN=FLC3 PE=1 SV=1 [Swiss-Prot] FLC3 Protein of unknown function localised to cell periphery [mips] Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER [SGD] YGL139W, Chr VII from 245719-248127 [yeast_orfs2] Chr VII from 245719-248127 [yeastorf3.fasta] YGL139W SGDID:S0003107, Chr VII from 245719-248127, Uncharacterized ORF [yeastflysequest.fasta] YGL139W SGDID:S0003107, Chr VII from 245721-248129, Uncharacterized ORF [10112005cervSGD.fasta] Ygl139wp [Saccharomyces cerevisiae]gi\|1322714\|emb\|CAA96851.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|2132550\|pir\|\|S64153 probable membrane protein YGL139w - yeast (Saccharomyces cerevisiae)gi\|1723922\|sp\|P53121\|YGN9_YEAST HYPOTHETICAL 90.8 [nrdb_11152004_Chlamydomonas] YGL139W SGDID:S000003107, Chr VII from 245721-248129, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] FLC3 SGDID:S000003107, Chr VII from 245721-248129, Verified ORF, "Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER" [yeast-contam.fasta] Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; Flc3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Putative flavin carrier protein 3 precursor (FAD transporter 3) (TRP-like ion channel FLC3) [nr-271106-contam.fasta] [chemostatdb.fasta] Putative flavin carrier protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FLC3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] FLC3 SGDID:S000003107, Chr VII from 245716-248124, Genome Release 64-1-1, Verified ORF, "Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER" [yeast-030211-contam.fasta] FLC3 SGDID:S000003107, Chr VII from 245716-248124, Genome Release 64-2-1, Verified ORF, "Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; FLC3 has a paralog, FLC1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YGL139W SGDID:S000003107, Chr VII from 245716-248124, Genome Release 64-1-1, Verified ORF, "Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	802 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ] integral to membrane [ISS] endoplasmic reticulum [IDA]
Biological Process:	FAD transport [ISS]
Molecular Function:	FAD transmembrane transporter activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFLQVYKSS ALIGLIILLA SKVNLAEAKR KLVATSLVTC MENSQLSANS FDVVFNPDDR  60
   61 SLHYDLDMST QIDSYIFADI DVYAYGFKII TKNVDLCSIN WKQFCPVHPG NIQIDSIEYI 120
  121 SSEYVNEIPG IAYQVPDIDA YARVKITNNV SEYLACIQIY FSNGKTVSQI GVKWATAVVA 180
  181 GIGLLLSAIL STFGNSTAAS HISANTMSLF LYFQSVVVVA MQHVHRVPPI AAAWAENLVW 240
  241 SMGLIRISFM QRIFRWYVQS TGGTPSLYLT STSMSVLAQR SWQYLMELPL IKRATNVLYG 300
  301 NANTLIFRGI KRLGYKMGIE NTSIVCTGFT FFVLCGYVLA GFIIVFKCCV ELATRLGWIQ 360
  361 KARFWEFRKQ WRMILKGALL RYIYIGFVQL TILSFWEFTE RDSPAVIVIA CLFILLSCGL 420
  421 MLWAAWRTVF FARRSVALYN NPAALLYGDE YVLHKYGFFY TMFNANHYWW NIVLLSYIFV 480
  481 KSLLVGFAQA SGQTQVLFMF ILDLFYFVAI IYYKPYLDRP TNIMNILIAT VTVVNSFLFM 540
  541 FFSDLFNQSY KVAAIMGWIF FIMNAAFSFI LLMMILAFAG MMLFSKNPDL RFKPAKDDRT 600
  601 SFQRNTMKPE GTVNRSVANE LLALGNVAKD HDDNSDYESN DTGVNDELKQ AQDETTPTTV 660
  661 TSSDDNKPTF SEKILSKFSR PKNENASTDA LRVEAPKQQT FPHNLTNLSR ENLSTLGSKP 720
  721 YPGHTRSQSD AHNGLINSFE EEDTSSNTDP FHDSTEGDLL DTSSSDGGFR SQNYVRDDSI 780
  781 NSLGNNKQPL RKPPGFFDEG FM

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC53	FLC3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	FLC3	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..192]	MSA	1.009955	View MSA. No confident structure predictions are available.
2	View Details	[193..301]	deduced	N/A	No confident structure predictions are available.
3	View Details	[302..579]	MSA	1.009936	View MSA. No confident structure predictions are available.
4	View Details	[580..749]	MSA	1.009974	View MSA. No confident structure predictions are available.
5	View Details	[750..802]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
potassium channel activity	5.34623321286043	bayes_pls_golite062009
voltage-gated potassium channel activity	5.3457739160783	bayes_pls_golite062009
metal ion transmembrane transporter activity	5.29167837952147	bayes_pls_golite062009
voltage-gated cation channel activity	4.9171616807315	bayes_pls_golite062009
cation channel activity	4.79161681210355	bayes_pls_golite062009
voltage-gated ion channel activity	4.75442765649412	bayes_pls_golite062009
voltage-gated channel activity	4.73153984947535	bayes_pls_golite062009
cation transmembrane transporter activity	4.54873661177894	bayes_pls_golite062009
ion transmembrane transporter activity	4.46212583884101	bayes_pls_golite062009
ion channel activity	4.19986580228506	bayes_pls_golite062009
inward rectifier potassium channel activity	4.11043455536373	bayes_pls_golite062009
gated channel activity	4.10310997393268	bayes_pls_golite062009
substrate-specific channel activity	4.09106677594218	bayes_pls_golite062009
channel activity	4.07346819712136	bayes_pls_golite062009
passive transmembrane transporter activity	4.07346819712136	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	4.06857483006075	bayes_pls_golite062009
ligand-gated ion channel activity	3.52286634234959	bayes_pls_golite062009
ligand-gated channel activity	3.52286634234959	bayes_pls_golite062009
transporter activity	2.35657262831396	bayes_pls_golite062009
transmembrane transporter activity	2.25147059981728	bayes_pls_golite062009
substrate-specific transporter activity	2.22751878261824	bayes_pls_golite062009
binding	1.96281708074635	bayes_pls_golite062009
G-protein activated inward rectifier potassium channel activity	1.65070971324325	bayes_pls_golite062009
hydrolase activity	1.63153428386052	bayes_pls_golite062009
protein binding	1.30086551295862	bayes_pls_golite062009
ATP-activated inward rectifier potassium channel activity	1.18849851204642	bayes_pls_golite062009
molecular transducer activity	0.525578079825295	bayes_pls_golite062009
signal transducer activity	0.525578079825295	bayes_pls_golite062009
clathrin binding	0.50269928917354	bayes_pls_golite062009
cytoskeletal protein binding	0.448241458604601	bayes_pls_golite062009
actin binding	0.328787215513486	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2