Protein Overview: HSF1

General Information:
Name(s) found:	HSF1 / YGL073W [SGD]
Description(s) found: SHOW ONLY BEST	pir\|\|A31593 heat shock transcription factor HSF1 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|6321364\|ref\|NP_011442.1\| Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regu [NCBI NR] gi\|171708\|gb\|AAA34688.1\| heat shock factor protein [NCBI NR] gi\|1322586\|emb\|CAA96777.1\| HSF1 [Saccharomyces cerevisiae] [NCBI NR] gi\|123687\|sp\|P10961.1\|HSF_YEAST RecName: Full=Heat shock factor protein; Short=HSF; AltName: Full=Heat shock transcription factor; Short=HSTF [NCBI NR] Heat shock factor protein OS=Saccharomyces cerevisiae GN=HSF1 PE=1 SV=1 [Swiss-Prot] HSF1 Heat shock transcription factor [mips] Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated [SGD] HSF1, Chr VII from 368751-371252 [yeast_orfs2] Chr VII from 368751-371252 [yeastorf3.fasta] Chr VII from 368754-371255 [yeastorf4.fasta] (P10961) Heat shock factor protein (HSF) (Heat shock transcription factor) (HSTF) [4932.FASTACCERV.txt] HSF1 SGDID:S0003041, Chr VII from 368754-371255, Verified ORF [yeastflysequest.fasta] HSF1 SGDID:S0003041, Chr VII from 368756-371257, Verified ORF [10112005cervSGD.fasta] Hsf1p [Saccharomyces cerevisiae]gi\|1322586\|emb\|CAA96777.1\| HSF1 [Saccharomyces cerevisiae]gi\|123687\|sp\|P10961\|HSF_YEAST Heat shock factor protein (HSF) (Heat shock transcription factor) (HSTF)gi\|83066\|pir\|\|A31593 heat shock transcription factor HSF1 - [nrdb_11152004_Chlamydomonas] HSF1 SGDID:S000003041, Chr VII from 368756-371257, Verified ORF, "Trimeric heat shock transcription factor, activates multiple genes in response to hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; constitu [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] HSF1 SGDID:S000003041, Chr VII from 368756-371257, Verified ORF, "Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted N [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] HSF1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Heat shock factor protein (HSF) (Heat shock transcription factor) (HSTF) [nr-271106-contam.fasta] Trimeric heat shock transcription factor, activates multiple genes in response to hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; constitutively DNA-bound; posttranslationally regulated; Hsf1p [Saccharomy [nr-271106-contam.fasta] heat shock factor protein [nr-271106-contam.fasta] HSF1 SGDID:S000003041, Chr VII from 368756-371257, Verified ORF, "Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated" [yeast-bovrabprots.fasta] HSF1 SGDID:S000003041, Chr VII from 368756-371257, Verified ORF, "Trimeric heat shock transcription factor, activates multiple genes in response to hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; constitutively DNA-bound; posttranslationally regulated" [yeast-contam_custom.fasta] [chemostatdb.fasta] Heat shock factor protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HSF1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] HSF1 SGDID:S000003041, Chr VII from 368753-371254, Genome Release 64-1-1, Verified ORF, "Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated" [yeast-030211-contam.fasta] HSF1 SGDID:S000003041, Chr VII from 368753-371254, Genome Release 64-2-1, Verified ORF, "Trimeric heat shock transcription factor; activates multiple genes in response to highly diverse stresses, including hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; monitors translational status of cell at the ribosome through an RQC (Ribosomal Quality Control)-mediated translation-stress signal; involved in diauxic shift; posttranslationally regulated" [20141208_orf_trans.fasta] YGL073W SGDID:S000003041, Chr VII from 368753-371254, Genome Release 64-1-1, Verified ORF, "Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	833 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] mitochondrion [IDA ]
Biological Process:	response to heat [IMP ] spindle pole body duplication [IMP] response to stress [IMP ] regulation of transcription from RNA polymerase II promoter [IDA]
Molecular Function:	transcription factor activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNAANTGTT NESNVSDAPR IEPLPSLNDD DIEKILQPND IFTTDRTDAS TTSSTAIEDI  60
   61 INPSLDPQSA ASPVPSSSFF HDSRKPSTST HLVRRGTPLG IYQTNLYGHN SRENTNPNST 120
  121 LLSSKLLAHP PVPYGQNPDL LQHAVYRAQP SSGTTNAQPR QTTRRYQSHK SRPAFVNKLW 180
  181 SMLNDDSNTK LIQWAEDGKS FIVTNREEFV HQILPKYFKH SNFASFVRQL NMYGWHKVQD 240
  241 VKSGSIQSSS DDKWQFENEN FIRGREDLLE KIIRQKGSSN NHNSPSGNGN PANGSNIPLD 300
  301 NAAGSNNSNN NISSSNSFFN NGHLLQGKTL RLMNEANLGD KNDVTAILGE LEQIKYNQIA 360
  361 ISKDLLRINK DNELLWQENM MARERHRTQQ QALEKMFRFL TSIVPHLDPK MIMDGLGDPK 420
  421 VNNEKLNSAN NIGLNRDNTG TIDELKSNDS FINDDRNSFT NATTNARNNM SPNNDDNSID 480
  481 TASTNTTNRK KNIDENIKNN NDIINDIIFN TNLANNLSNY NSNNNAGSPI RPYKQRYLLK 540
  541 NRANSSTSSE NPSLTPFDIE SNNDRKISEI PFDDEEEEET DFRPFTSRDP NNQTSENTFD 600
  601 PNRFTMLSDD DLKKDSHTND NKHNESDLFW DNVHRNIDEQ DARLQNLENM VHILSPGYPN 660
  661 KSFNNKTSST NTNSNMESAV NVNSPGFNLQ DYLTGESNSP NSVHSVPSNG SGSTPLPMPN 720
  721 DNDTEHASTS VNQGENGSGL TPFLTVDDHT LNDNNTSEGS TRVSPDIKFS ATENTKVSDN 780
  781 LPSFNDHSYS TQADTAPENA KKRFVEEIPE PAIVEIQDPT EYNDHRLPKR AKK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		CDC6 HSF1 YLR419W

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	KOG1	No Comments	Reinke A, et al. (2004)
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PLM2	HSF1	1	Unpublished Fields Lab Data
View Screen	SPT23	HSF1	1	Unpublished Fields Lab Data
View Screen	UBC7	HSF1	1	Unpublished Fields Lab Data
View Screen	YIF1	HSF1	1	Unpublished Fields Lab Data
View Screen	SEC17	HSF1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	HSF1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..145]	deduced	N/A	No confident structure predictions are available.
2	View Details	[146..260]	PSI-BLAST	363.218487	Heat-shock transcription factor
3	View Details	[261..319]	ab initio	9.77	No description for 3htsB was found.
4	View Details	[320..833]	ab initio	7.24	No description for 1i3qA was found.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2