Protein Overview: MOB2

General Information:
Name(s) found:	MOB2 / YFL034C-B [SGD]
Description(s) found: Found 33 descriptions. SHOW ALL	Component of the RAM signaling network, that activates the Cbk1p kinase, thereby facilitating the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	287 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cellular bud [IDA] cellular bud neck [IDA] mating projection tip [TAS]
Biological Process:	cell morphogenesis during vegetative growth [IGI] regulation of exit from mitosis [IMP] protein amino acid phosphorylation [IDA]
Molecular Function:	protein kinase activator activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFFNFKAFG RNSKKNKNQP LNVAQPPAMN TIYSSPHSSN SRLSLRNKHH SPKRHSQTSF  60
   61 PAQKSTPQSQ QLTSTTPQSQ QQEASERSES QQIMFLSEPF VRTALVKGSF KTIVQLPKYV 120
  121 DLGEWIALNV FEFFTNLNQF YGVVAEYVTP DAYPTMNAGP HTDYLWLDAN NRQVSLPASQ 180
  181 YIDLALTWIN NKVNDKNLFP TKNGLPFPQQ FSRDVQRIMV QMFRIFAHIY HHHFDKIVHL 240
  241 SLEAHWNSFF SHFISFAKEF KIIDRKEMAP LLPLIESFEK QGKIIYN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		ARP2 CBK1 MOB2 SEC28 SIS1 TAO3 VMA6
View Details	Qiu et al. (2008)		CBK1 CDC24 GIC1 GIC2 KIC1 MOB1 MOB2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	GBP2	MOB2	2	Unpublished Fields Lab Data
View Screen	RPT4	MOB2	2	Unpublished Fields Lab Data
View Screen	DMA1	MOB2	1	Unpublished Fields Lab Data
View Screen	NAF1	MOB2	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	MOB2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..64]	deduced	N/A	No confident structure predictions are available.
2	View Details	[65..287]	Pfam	112.142668	Mob1/phocein family No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
binding	1.92301852481284	bayes_pls_golite062009
kinase regulator activity	1.89112613830997	bayes_pls_golite062009
enzyme regulator activity	1.85961781963242	bayes_pls_golite062009
protein binding	1.70532605681329	bayes_pls_golite062009
protein kinase regulator activity	1.22656624834768	bayes_pls_golite062009
enzyme activator activity	1.01199608762933	bayes_pls_golite062009
kinase activator activity	0.48120280834988	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2