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Protein Overview: PTP3

General Information:
Name(s) found: PTP3 / YER075C [SGD]
Description(s) found:
Found 21 descriptions.
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  • Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 928 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: inactivation of MAPK activity involved in osmosensory signaling pathway [IMPLink to PubMed article][IPILink to PubMed article]
    protein amino acid dephosphorylation [IDALink to PubMed article][IMPLink to PubMed article]
    pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein tyrosine phosphatase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDSVDCPSI LPTDRTSVLS ETSTLVGSSS HVYSRHAPMN SYHNSMNSNI YHSPKASSPL  60
   61 VSYKTSSPVL LKRATAPVLP SFKPKEQRYN KPQGCSLITA VELGKIIETL PDEKVLLLDV 120
  121 RPFTEHAKSI ITNSIHVCLP STLLRRKNFT FSKLLDNLTP SEQSVLKSKL AIDNLRIIIY 180
  181 DSTANQTESS VSLPCYGIAS KLIEFDTNVK KTVSILMCGF PQFKILFPDH INTNTFNSDC 240
  241 ISSAEPKSPK TNLMNSLHNT APHMTATTPL SSPQMNLKLK VPDDSRSDHS NFSSSPSPRN 300
  301 VLSDSPMSSS SPISALFKFQ LPAPQTNINQ MFKFSQNEEI MGLETYLSAV NIKEEHERWY 360
  361 NNDSAKKSLQ NFQFPKNQNS LEKDTNKDKL GFQIRYENLS KNYEKEVIDS VIPEWFQHLM 420
  421 SIPKIELVSQ FQKLDFLEKR RLNHSVSFRK KENSFILEKP SSYPEQLTST SSSTIMPPKF 480
  481 PDVNKVQKRS HSQPIFTQYS KYKSMLSLES DSDSESDDVI ISSGVELGAK NRYKDIFPYE 540
  541 HSRVILKKGL QSSKGIKHSH STSDGGILDN YINANYLSLP RFSVEQNSSF QTTTTTTRRV 600
  601 RYIATQAPMP STVHDFYTCI LNNGVPLVLS LTNDFENGIE KCYRYWQEGN YNGIHVKLLE 660
  661 KKILKMPSTT SMRKNTMGTQ NSSLYSAGVQ GNSSNYSTDN DNDNDNNNNN NNNSNIPVTA 720
  721 AACDDDDDDD DDAILIRQIL LTYHDQEKPY ELLQIQVKNW PDLGTLLNPI SILQAINVKN 780
  781 HIIDTLFARN YYQNDQLPTI LVHCSAGCGR TGTLCTIDSI LSNFEMFEML QKEFVKLKYP 840
  841 AKLFDPISWT INIFRKERIS MVQNINQFIF IYDCLLFYFR LRLDDITERT DGDGSNKDNI 900
  901 SLSALIEQIE KLEILQTFVD DKLKELPQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) FET4 HHF1, HHF2 PTP3 RRP5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HNT1 PTP3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PTP3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] deduced N/A No confident structure predictions are available.
    2 View Details [81..248] PSI-BLAST 7.221849 Erk2 binding domain of Mapk phosphatase mkp-3
    3 View Details [249..491] MSA 6.190997 View MSA. No confident structure predictions are available.
    4 View Details [492..793] PSI-BLAST 241.9691 Tyrosine phosphatase
    5 View Details [794..928] ORFEUS 14.89 Tyrosine phosphatase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  4.79074052803751 bayes_pls_golite062009
  • phosphatase activity
    		•  4.08369475076737 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  3.88616276399434 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  3.24681684836294 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  2.84204105189999 bayes_pls_golite062009
  • hydrolase activity
    		•  2.12055507229256 bayes_pls_golite062009
  • binding
    		•  1.72957395505299 bayes_pls_golite062009
  • catalytic activity
    		•  0.687308230067573 bayes_pls_golite062009
  • thiosulfate sulfurtransferase activity
    		•  0.621422565731405 bayes_pls_golite062009
  • protein binding
    		•  0.515609053278812 bayes_pls_golite062009
  • transferase activity
    		•  0.302497611306574 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle