Protein Overview: SDC1

General Information:
Name(s) found:	SDC1 / YDR469W [SGD]
Description(s) found: Found 28 descriptions. SHOW ALL	Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 [SGD]
Organism:	Saccharomyces cerevisiae
Length:	175 amino acids
Gene Ontology:
Cellular Component:	Set1C/COMPASS complex [IPI ]
Biological Process:	histone methylation [IDA ][IMP ] chromatin silencing at telomere [IMP ]
Molecular Function:	histone methyltransferase activity (H3-K4 specific) [IDA ][IMP ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNESENSPQH NEVTVPMVED TSSNADIPME QIQREDNKNY DKHDNECFDM NGNHNNNSDN  60
   61 LQFDSVPSSA TKDLKNIKSV TNQNVKIEES SSTNSVIEES SEPKISKLEN VNLAATVGGS 120
  121 QTRKYLNTNV TPHLLAGMRL IAVQQPEDPL RVLGEYLIEQ SNILKSGEKE SNASK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		BRE2 SDC1 SET1 SHG1 SPP1 SWD1 SWD2 SWD3
View Details	Krogan NJ, et al. (2006)		BRE2 ERF2 SDC1 SET1 SHG1 SPP1 SWD1 SWD3 YHI9 YLL023C
View Details	Gavin AC, et al. (2006)		BRE2 SDC1 SET1 SPP1 SWD1 SWD3
View Details	Gavin AC, et al. (2002)		BRE2 DOA4 RSM7 SDC1 SET1 SPP1 SSZ1 SWD1 SWD3
View Details	Qiu et al. (2008)		BRE2 SDC1 SET1 SHG1 SPP1 SWD1 SWD2 SWD3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RCY1	SDC1	1	Unpublished Fields Lab Data
View Screen	PRP16	SDC1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SDC1	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..175]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2