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Protein Overview: SRP101

General Information:
Name(s) found: SRP101 / YDR292C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with Srp102p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 621 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article]
    signal recognition particle receptor complex [TASLink to PubMed article]
    Biological Process: SRP-dependent cotranslational protein targeting to membrane [ICLink to PubMed article][TASLink to PubMed article]
    protein targeting to ER [IMPLink to PubMed article]
    Molecular Function: GTP binding [IPILink to PubMed article]
    signal recognition particle binding [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFDQLAVFTP QGQVLYQYNC LGKKFSEIQI NSFISQLITS PVTRKESVAN ANTDGFDFNL  60
   61 LTINSEHKNS PSFNALFYLN KQPELYFVVT FAEQTLELNQ ETQQTLALVL KLWNSLHLSE 120
  121 SILKNRQGQN EKNKHNYVDI LQGIEDDLKK FEQYFRIKYE ESIKQDHINP DNFTKNGSVP 180
  181 QSHNKNTKKK LRDTKGKKQS TGNVGSGRKW GRDGGMLDEM NHEDAAKLDF SSSNSHNSSQ 240
  241 VALDSTINKD SFGDRTEGGD FLIKEIDDLL SSHKDEITSG NEAKNSGYVS TAFGFLQKHV 300
  301 LGNKTINESD LKSVLEKLTQ QLITKNVAPE AADYLTQQVS HDLVGSKTAN WTSVENTARE 360
  361 SLTKALTQIL TPGVSVDLLR EIQSKRSKKD EEGKCDPYVF SIVGVNGVGK STNLSKLAFW 420
  421 LLQNNFKVLI VACDTFRSGA VEQLRVHVEN LAQLMDDSHV RGSKNKRGKT GNDYVELFEA 480
  481 GYGGSDLVTK IAKQAIKYSR DQNFDIVLMD TAGRRHNDPT LMSPLKSFAD QAKPDKIIMV 540
  541 GEALVGTDSV QQAKNFNDAF GKGRNLDFFI ISKCDTVGEM LGTMVNMVYA TGIPILFVGV 600
  601 GQTYTDLRTL SVKWAVNTLM S

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SRP101 SRP102
    View Details (MIPS) Mewes HW, et al. (2004) SRP101 SRP102
    View Details Gavin AC, et al. (2006) SRP101 SRP102
    View Details Gavin AC, et al. (2002) SRP101 SRP102
    View Details Qiu et al. (2008) SBH1 SRP101 SRP102

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] MSA 4.209996 View MSA. No confident structure predictions are available.
    2 View Details [216..272] deduced N/A No confident structure predictions are available.
    3 View Details [273..293]
    [363..621]    		 PSI-BLAST 271.491979 Signal recognition particle receptor, FtsY; GTPase domain of the signal recognition particle receptor FtsY
    4 View Details [294..362] PSI-BLAST 271.491979 Signal recognition particle receptor, FtsY; GTPase domain of the signal recognition particle receptor FtsY

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • signal recognition particle binding
    		•  6.13359612945359 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  3.69979261496156 bayes_pls_golite062009
  • palmitoyltransferase activity
    		•  2.39665981402803 bayes_pls_golite062009
  • protein-cysteine S-palmitoleyltransferase activity
    		•  2.13678994750168 bayes_pls_golite062009
  • protein-cysteine S-acyltransferase activity
    		•  2.13678994750168 bayes_pls_golite062009
  • protein transporter activity
    		•  2.04806587835812 bayes_pls_golite062009
  • transporter activity
    		•  1.71943098913274 bayes_pls_golite062009
  • SNAP receptor activity
    		•  1.47915598483249 bayes_pls_golite062009
  • protein binding
    		•  1.08917223347521 bayes_pls_golite062009
  • binding
    		•  1.08343499631215 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.939682472116899 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.131410992694836 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0936690070284361 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0846345824909659 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0820309452260982 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle