Protein Overview: RAD9

General Information:
Name(s) found:	RAD9 / YDR217C [SGD]
Description(s) found: Found 23 descriptions. SHOW ALL	DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate [SGD]
Organism:	Saccharomyces cerevisiae
Length:	1309 amino acids
Gene Ontology:
Cellular Component:	nucleus [IC]
Biological Process:	DNA damage checkpoint [IMP] DNA repair [IGI][IMP] nucleotide-excision repair [IMP] positive regulation of transcription from RNA polymerase II promoter [IMP]
Molecular Function:	protein binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGQLVQWKS SPDRVTQSAI KEALHSPLAD GDMNEMNVPV DPLENKVNST NIIEGSPKAN  60
   61 PNPVKFMNTS EIFQKSLGLL DESPRHDDEL NIEVGDNDRP NANILHNERT PDLDRIANFF 120
  121 KSNRTPGKEN LLTKYQSSDL EDTPLMLRKK MTFQTPTDPL EQKTFKKLKS DTGFCYYGEQ 180
  181 NDGEENASLE VTEADATFVQ MAERSADNYD CALEGIVTPK RYKDELSKSG GMQDERVQKT 240
  241 QIMISAESPN SISSYDKNKI TGNGRTTRNV NKVFNNNEDN IGAIEEKNPV KKKSENYSSD 300
  301 DLRERNNQII QSNESEEINE LEKNLNVSGR ENDVNNLDID INSAVSGTPS RNNAEEEMYS 360
  361 SESVNNREPS KKWIFRYSKD KTENNSNRST QIVNNPRTQE MPLDSISIDT QPLSKSFNTE 420
  421 TNNELETQII VSSLSQGISA QKGPVFHSTG QTEEIKTQII NSPEQNALNA TFETPVTLSR 480
  481 INFEPILEVP ETSSPSKNTM SKPSNSSPIP KEKDTFNIHE REVETNNVFS NDIQNSSNAA 540
  541 TRDDIIIAGS SDFNEQKEIT DRIYLQLSGK QISDSGSDET ERMSPNELDT KKESTIMSEV 600
  601 ELTQELPEVE EQQDLQTSPK KLVVEEETLM EIKKSKGNSL QLHDDNKECN SDKQDGTESL 660
  661 DVALIEHESK GQSSELQKNL MQLFPSESQE IIQNRRTIKR RQKDTIEIGE EEENRSTKTS 720
  721 PTKHLKRNSD LDAASIKREP SCSITIQTGE TGSGKDSKEQ SYVFPEGIRT ADNSFLSKDD 780
  781 IIFGNAVWCQ YTWNYKFYPG ILLEVDTNQD GCWIYFETGR SLTKDEDIYY LDIRIGDAVT 840
  841 FDGNEYVVVG LECRSHDLNI IRCIRGYDTV HLKKKNASGL LGKRTLIKAL SSISLDLSEW 900
  901 AKRAKIILED NEKNKGDAYR YLRHPIRGRK SMTNVLSPKK HTDDEKDINT HTEVYNNEIE 960
  961 SSSEKKEIVK KDSRDALAEH AGAPSLLFSS GEIRTGNVFD KCIFVLTSLF ENREELRQTI1020
 1021 ESQGGTVIES GFSTLFNFTH PLAKSLVNKG NTDNIRELAL KLAWKPHSLF ADCRFACLIT1080
 1081 KRHLRSLKYL ETLALGWPTL HWKFISACIE KKRIVPHLIY QYLLPSGESF RLSLDSPSKG1140
 1141 GIIKSNNIFS FYTQFLRGSN LRDQICGVKK MLNDYIVIVW GRSELDSFVK FAFACLSAGR1200
 1201 MLTIDLPNID VDDTEPLLNA LDSLVPRIGS ELSNRKLKFL IYANENNGKS QMKLLERLRS1260
 1261 QISLKFKKFN YIFHTESKEW LIQTIINEDT GFHDDITDND IYNTISEVR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		DUN1 RAD9

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RAD9	RAD53	2	Unpublished Fields Lab Data
View Screen	RAD9	RRM3	2	Unpublished Fields Lab Data
View Screen	CHK1	RAD9	2	Unpublished Fields Lab Data
View Screen	RAD9	CHK1	2	Unpublished Fields Lab Data
View Screen	RAD9	EDC3	1	Unpublished Fields Lab Data
View Screen	RAD9	SPO19	1	Unpublished Fields Lab Data
View Screen	RAD9	SPT15	1	Unpublished Fields Lab Data
View Screen	RAD9	YPL142C	1	Unpublished Fields Lab Data
View Screen	RAD9	YGR067C	1	Unpublished Fields Lab Data
View Screen	RAD9	ASN2	1	Unpublished Fields Lab Data
View Screen	RAD9	FUM1	1	Unpublished Fields Lab Data
View Screen	RAD9	MGA1	1	Unpublished Fields Lab Data
View Screen	RAD9	RSC30	1	Unpublished Fields Lab Data
View Screen	RAD9	YKR075C	1	Unpublished Fields Lab Data
View Screen	RAD9	PSR1	1	Unpublished Fields Lab Data
View Screen	RAD9	APC9	1	Unpublished Fields Lab Data
View Screen	RAD9	PRE8	1	Unpublished Fields Lab Data
View Screen	RAD9	WHI2	1	Unpublished Fields Lab Data
View Screen	RAD9	PCA1	1	Unpublished Fields Lab Data
View Screen	RAD9	CRC1	1	Unpublished Fields Lab Data
View Screen	RAD9	FYV5	1	Unpublished Fields Lab Data
View Screen	RAD9	TFC7	1	Unpublished Fields Lab Data
View Screen	RAD9	BUD23	1	Unpublished Fields Lab Data
View Screen	RAD9	YPL025C	1	Unpublished Fields Lab Data
View Screen	RAD9	HCM1	1	Unpublished Fields Lab Data
View Screen	RAD9	ELP3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	RAD9	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..991]	deduced	N/A	No confident structure predictions are available.
2	View Details	[992..1135]	Pfam	11.031517	BRCA1 C Terminus (BRCT) domain No confident structure predictions are available.
3	View Details	[1136..1309]	deduced	N/A	No confident structure predictions are available.
4	View Details	[366..505]	deduced	N/A	No confident structure predictions are available.
5	View Details	[506..761]	deduced	N/A	No confident structure predictions are available.
6	View Details	[762..911]	Pfam	82.69897	No description for PF08605.1 was found. No confident structure predictions are available.
7	View Details	[912..988]	deduced	N/A	No confident structure predictions are available.
8	View Details	[989..1309]	FFAS03	2.44	53BP1

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2