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Protein Overview: SLY1

General Information:
Name(s) found: SLY1 / YDR189W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 666 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article]
    Golgi apparatus [IDALink to PubMed article]
    ER to Golgi transport vesicle [IDALink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IMPLink to PubMed article]
    Molecular Function: SNARE binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVEEIASRK DISLRDMQIS AILKMLFLNK DLNNNDNITT ITDDIFNQQE IIWKVLILDI  60
   61 KSTATISSVL RVNDLLKAGI TVHSLIKQDR SPLPDVPAIY FVSPTKENID IIVNDLKSDK 120
  121 YSEFYINFTS SLPRNLLEDL AQQVSITGKS DKIKQVYDQY LDFIVTEPEL FSLEISNAYL 180
  181 TLNDPKTTEE EITGLCANIA DGLFNTVLTI NSIPIIRAAK GGPAEIIAEK LGTKLRDFVI 240
  241 NTNSSSTSTL QGNDSLERGV LIILDRNIDF ASMFSHSWIY QCMVFDIFKL SRNTVTIPLE 300
  301 SKENGTDNTT AKPLATKKYD IEPNDFFWME NSHLPFPEAA ENVEAALNTY KEEAAEITRK 360
  361 TGVTNISDLD PNSNNDTVQI QEVVKKLPEL TAKKNTIDTH MNIFAALLSQ LESKSLDTFF 420
  421 EVEQDPGSTK TRSRFLDILK DGKTNNLEDK LRSFIVLYLT STTGLPKDFV QNVENYFKEN 480
  481 DYDINALKYV YKLREFMQLS NMSLQNKSLE DGSDSAFKPS NLTLSGIYGL TEGKLQGGVG 540
  541 SLISGIKKLL PEKKTIPITN VVDAIMDPLN SSQKNLETTD SYLYIDPKIT RGSHTRKPKR 600
  601 QSYNKSLVFV VGGGNYLEYQ NLQEWAHSQL HNPKKVMYGS TAITTPAEFL NEISRLGASN 660
  661 SSNNDA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) SED5 SLY1
    View Details Gavin AC, et al. (2002) SEC17 SLY1 TLG1 TLG2 VPS45 VTI1 YKT6
    View Details Qiu et al. (2008) SEC21 SEC22 SLY1 YOS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SDO1 No Comments Hazbun TR, et al. (2003)
    View Run CWC2 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SLY1 LAP3 2 Unpublished Fields Lab Data
    View Screen SLY1 UFE1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SLY1 and ANP1 Huh WK, et al. (2003)
    View Data SLY1 Huh WK, et al. (2003)
    View Data SLY1 and COP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..160] PSI-BLAST 392.9897 Neuronal Sec1, NSec1
    2 View Details [161..278]
    [562..666]    		 PSI-BLAST 392.9897 Neuronal Sec1, NSec1
    3 View Details [279..412] PSI-BLAST 392.9897 Neuronal Sec1, NSec1
    4 View Details [413..561] PSI-BLAST 392.9897 Neuronal Sec1, NSec1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • SNARE binding
    		•  4.56428593085019 bayes_pls_golite062009
  • syntaxin binding
    		•  3.46044132736061 bayes_pls_golite062009
  • binding
    		•  2.7837022903231 bayes_pls_golite062009
  • protein binding
    		•  2.77285532000616 bayes_pls_golite062009
  • syntaxin-1 binding
    		•  0.269372794919901 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle