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Protein Overview: PDC2

General Information:
Name(s) found: PDC2 / YDR081C [SGD]
Description(s) found:
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  • gi|6320286|ref|NP_010366.1| Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes; Pdc2p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S48768 regulatory protein PDC2 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|577808|emb|CAA86803.1| Pdc2p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|558252|emb|CAA57608.1| D4451 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1431551|emb|CAA98900.1| PDC2 [Saccharomyces cerevisiae] [NCBI NR]
  • PDC2 Pyruvate decarboxylase regulatory protein [mips]
  • Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes [SGD]
  • PDC2, Chr IV from 607298-610075, reverse complement [yeast_orfs2]
  • Chr IV from 607298-610075, reverse complement [yeastorf3.fasta]
  • Chr IV from 610075-607298, reverse complement [yeastorf5.fasta]
  • PDC2 SGDID:S0002488, Chr IV from 610076-607299, reverse complement, Verified ORF [yeastflysequest.fasta]
  • PDC2 SGDID:S0002488, Chr IV from 610077-607300, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Pdc2p [Saccharomyces cerevisiae]gi|558252|emb|CAA57608.1| D4451 [Saccharomyces cerevisiae]gi|1431551|emb|CAA98900.1| PDC2 [Saccharomyces cerevisiae]gi|577808|emb|CAA86803.1| Pdc2p [Saccharomyces cerevisiae]gi|630100|pir||S48768 regulatory protein PDC2 [nrdb_11152004_Chlamydomonas]
  • PDC2 SGDID:S000002488, Chr IV from 610077-607300, reverse complement, Verified ORF, "Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PDC2 SGDID:S000002488, Chr IV from 610078-607301, reverse complement, Verified ORF, "Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes" [yeast-contam.fasta]
  • PDC2 SGDID:S000002488, Chr IV from 610079-607302, reverse complement, Verified ORF, "Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • D4451 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes; Pdc2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PDC2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Pdc2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Protein PDC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDC2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PDC2 SGDID:S000002488, Chr IV from 610081-607304, Genome Release 64-1-1, reverse complement, Verified ORF, "Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes" [yeast-030211-contam.fasta]
  • PDC2 SGDID:S000002488, Chr IV from 610081-607304, Genome Release 64-2-1, reverse complement, Verified ORF, "Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions" [20141208_orf_trans.fasta]
  • YDR081C SGDID:S000002488, Chr IV from 610081-607304, Genome Release 64-1-1, reverse complement, Verified ORF, "Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 925 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    Biological Process: transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    glucose catabolic process to ethanol [IMPLink to PubMed article]
    thiamin biosynthetic process [TASLink to PubMed article]
    Molecular Function: transcription regulator activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSIQQRYNI CLMAERHPKW TQLELAKWAY ETFQLPKIPS QGTISRLLAR KSTYMNCKEH  60
   61 EKDANRLRKP NNLLVRKILQ EWISQSLWNG IPITSPIIQD TAQAVWHRIP AEHREGNGSF 120
  121 SYKWISNFLS KMDVNISVLD EELPKTPKVW TFEERDVLKA YFSKIPPKDL FTLDEAFLSY 180
  181 NLPLDYAQYE ASSIQRRIEV ATVMLCSNLD GSEKLKPVVV GKYDSYKSFR NYFPNEPNDP 240
  241 VSQSMLGTKM AKKFDISYHS NRKAWLTSNL FHNWLVRWDK RLVAVNRKIW IVLDDSCCHR 300
  301 IINLRLQNIK LVYTSSNSKF LPFNWGVWDE FKTRYRIQQY QALIDLQNRI SKNIQNKNKS 360
  361 ERNECIPNGK KCLISFEQSQ LTMSNAFKFI KKAWDDIPVD AIKANWKSSG LLPPEMIHLN 420
  421 ENVSMAFKKN EVLESVLNRL CDEYYCVKKW EYEMLLDLNI ENKNTNFLST EELVESAIVE 480
  481 PCEPDFDTAP KGNEVHDDNF DVSVFANEDD NNQNHLSMSQ ASHNPDYNSN HSNNAIENTN 540
  541 NRGSNNNNNN NGSSNNINDN DSSVKYLQQN TVDNSTKTGN PGQPNISSME SQRNSSTTDL 600
  601 VVDGNYDVNF NGLLNDPYNT MKQPGPLDYN VSTLIDKPNL FLSPDLDLST VGVDMQLPSS 660
  661 EYFSEVFSSA IRNNEKAASD QNKSTDELPS STAMANSNSI TTALLESRNQ AQPFDVPHMN 720
  721 GLLSDTSKSG HSVNSSNAIS QNSLNNFQHN SASVAEASSP SITPSPVAIN STGAPARSII 780
  781 SAPIDSNSSA SSPSALEHLE GAVSGMSPSS TTILSNLQTN INIAKSLSTI MKHAESNEIS 840
  841 LTKETINELN FNYLTLLKRI KKTRKQLNSE SIKINSKNAQ DHLETLLSGA AAAAATSANN 900
  901 LDLPTGGSNL PDSNNLHLPG NTGFF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GFA1 PDC2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HMT1 PDC2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PDC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..68] PSI-BLAST 72.69897 Ars-binding protein 1, ABP1
    2 View Details [69..148] PSI-BLAST 72.69897 Ars-binding protein 1, ABP1
    3 View Details [149..432] Pfam 127.119186 DDE superfamily endonuclease No confident structure predictions are available.
    4 View Details [433..804] MSA 24.194997 View MSA. No confident structure predictions are available.
    5 View Details [805..925] deduced N/A Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.41876985649951 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.09724849396574 bayes_pls_golite062009
  • transcription factor activity
    		•  3.86239731611043 bayes_pls_golite062009
  • binding
    		•  3.55096238224843 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.32406445003946 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.50301355818265 bayes_pls_golite062009
  • protein binding
    		•  1.44503155604344 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.12996981272574 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle