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Protein Overview: KCS1

General Information:
Name(s) found: KCS1 / YDR017C [SGD]
Description(s) found:
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  • gi|840870|emb|CAA89842.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|74645064|sp|Q12494.1|KCS1_YEAST RecName: Full=Inositol hexakisphosphate kinase 1; Short=InsP6 kinase 1; AltName: Full=InsP6 kinase KCS1; AltName: Full=PKC1 suppressor protein 1 [NCBI NR]
  • gi|6320220|ref|NP_010300.1| Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere ma [NCBI NR]
  • gi|1478442|gb|AAB36234.1| Kcs1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1431442|emb|CAA98837.1| KCS1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1216223|emb|CAA65208.1| orf:PZF1050 [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S54640 KCS1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Inositol hexakisphosphate kinase 1 OS=Saccharomyces cerevisiae GN=KCS1 PE=1 SV=1 [Swiss-Prot]
  • KCS1 Potential transcription factor of the BZIP type [mips]
  • Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance [SGD]
  • KCS1, Chr IV from 479110-482262, reverse complement [yeast_orfs2]
  • Chr IV from 479110-482262, reverse complement [yeastorf3.fasta]
  • Chr IV from 482262-479110, reverse complement [yeastorf5.fasta]
  • >Q12494 (Q12494) Chromosome IV reading frame ORF YDR017C [4932.FASTACCERV.txt]
  • KCS1 SGDID:S0002424, Chr IV from 482263-479111, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Inositol hexaphosphate kinase, phosphorylates inositol hexakisphosphate (InsP6) to diphosphoinositol polyphosphates, required for proper vacuole morphology and involved in salt stress response, contains two leucine heptad repeats [Saccharomyces cerevisiae [nrdb_11152004_Chlamydomonas]
  • (Q12494) KCS1 protein (Orf:PZF1050 protein) (Hypothetical protein) [cerv4932.FASTAC]
  • KCS1 SGDID:S000002424, Chr IV from 482263-479111, reverse complement, Verified ORF, "Inositol hexaphosphate kinase, phosphorylates inositol hexakisphosphate (InsP6) to diphosphoinositol polyphosphates, required for proper vacuole morphology and involved i [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • KCS1 SGDID:S000002424, Chr IV from 482264-479112, reverse complement, Verified ORF, "Inositol hexaphosphate kinase, phosphorylates inositol hexakisphosphate (InsP6) to diphosphoinositol polyphosphates, required for proper vacuole morphology and involved i [yeast-contam.fasta]
  • KCS1 SGDID:S000002424, Chr IV from 482265-479113, reverse complement, Verified ORF, "Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes suc [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Kcs1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • KCS1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Inositol hexaphosphate kinase, phosphorylates inositol hexakisphosphate (InsP6) to diphosphoinositol polyphosphates, required for proper vacuole morphology and involved in salt stress response, contains two leucine heptad repeats; Kcs1p [Saccharomyces cer [nr-271106-contam.fasta]
  • orf:PZF1050 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • KCS1 SGDID:S000002424, Chr IV from 482265-479113, reverse complement, Verified ORF, "Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance" [yeast-bovrabprots.fasta]
  • KCS1 SGDID:S000002424, Chr IV from 482264-479112, reverse complement, Verified ORF, "Inositol hexaphosphate kinase, phosphorylates inositol hexakisphosphate (InsP6) to diphosphoinositol polyphosphates, required for proper vacuole morphology and involved in salt stress response, contains two leucine heptad repeats" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Inositol hexakisphosphate kinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KCS1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • KCS1 SGDID:S000002424, Chr IV from 482267-479115, Genome Release 64-1-1, reverse complement, Verified ORF, "Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance" [yeast-030211-contam.fasta]
  • KCS1 SGDID:S000002424, Chr IV from 482267-479115, Genome Release 64-2-1, reverse complement, Verified ORF, "Inositol hexakisphosphate and inositol heptakisphosphate kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response, and telomere maintenance; inositol hexakisphosphate is also known as IP6; inositol heptakisphosphate is also known as IP7" [20141208_orf_trans.fasta]
  • YDR017C SGDID:S000002424, Chr IV from 482267-479115, Genome Release 64-1-1, reverse complement, Verified ORF, "Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1050 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: vacuole organization [IMPLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    regulation of phosphate metabolic process [IMPLink to PubMed article]
    response to stress [IMPLink to PubMed article]
    Molecular Function: inositol hexakisphosphate kinase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTSHEIHDK IPDTLREQQQ HLRQKESEGC ITTLKDLNVP ETKKLSSVLH GRKASTYLRI  60
   61 FRDDECLADN NNGVDSNNGG SVTCADKITR SEATPKSVPE GLQVSEKKNN PDTLSSSLSS 120
  121 FILSNHEEPA IKPNKHVAHR NNITETGQGS GEDIAKQQSH QPQVLHHQTS LKPIQNVDEG 180
  181 CISPKSTYQE SLHGISEDLT LKPVSSATYY PHKSKADSGY EEKDKMENDI DTIQPATINC 240
  241 ASGIATLPSS YNRHTFKVKT YSTLSQSLRQ ENVNNRSNEK KPQQFVPHSE SIKEKPNTFE 300
  301 QDKEGEQADE EEDEGDNEHR EYPLAVELKP FTNRVGGHTA IFRFSKRAVC KALVNRENRW 360
  361 YENIELCHKE LLQFMPRYIG VLNVRQHFQS KDDFLSDLDQ ENNGKNDTSN ENKDIEVNHN 420
  421 NNDDIALNTE PTGTPLTHIH SFPLEHSSRQ VLEKEHPEIE SVHPHVKRSL SSSNQPSLLP 480
  481 EVVLNDNRHI IPESLWYKYS DSPNSAPNDS YFSSSSSHNS CSFGERGNTN KLKRRDSGST 540
  541 MINTELKNLV IREVFAPKCF RRKRNSNTTT MGNHNARLGS SPSFLTQKSR ASSHDASNTS 600
  601 MKTLGDSSSQ ASLQMDDSKV NPNLQDPFLK KSLHEKISNA LDGSHSVMDL KQFHKNEQIK 660
  661 HKNSFCNSLS PILTATNSRD DGEFATSPNY ISNAQDGVFD MDEDTGNETI NMDNHGCHLD 720
  721 SGKNMIIKSL AYNVSNDYSH HDIESITFEE TSHTIVSKFI LLEDLTRNMN KPCALDLKMG 780
  781 TRQYGVDAKR AKQLSQRAKC LKTTSRRLGV RICGLKVWNK DYYITRDKYF GRRVKVGWQF 840
  841 ARVLARFLYD GKTIESLIRQ IPRLIKQLDT LYSEIFNLKG YRLYGASLLL MYDGDANKSN 900
  901 SKRKKAANVK VNLIDFARCV TKEDAMECMD KFRIPPKSPN IEDKGFLRGV KSLRFYLLLI 960
  961 WNYLTSDMPL IFDEVEMNDM ISEEADSNSF TSATGSKINF NSKWDWLDEF DKEDEEMYND1020
 1021 PNSKLRQKWR KYELIFDAEP RYNDDAQVSD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) KCS1 YMR196W
    View Details Ho Y, et al. (2002) ADR1 BMH1 BNR1 BOI2 CSR2 CYK3 GSY2 KCS1 NTH1 REG1 SOK1 STU1 SVL3 YFR017C YIL028W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CIA1 KCS1 2 Hazbun TR, et al. (2003)
    View Screen YDR131C KCS1 1 Unpublished Fields Lab Data
    View Screen CDC23 KCS1 1 Unpublished Fields Lab Data
    View Screen UBC7 KCS1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data KCS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..594] deduced N/A No confident structure predictions are available.
    2 View Details [595..986] Pfam 23.040959 Inositol polyphosphate kinase No confident structure predictions are available.
    3 View Details [987..1050] deduced N/A No confident structure predictions are available.
    4 View Details [965..1050] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle