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Protein Overview: NTH1

General Information:
Name(s) found: NTH1 / YDR001C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 751 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    cytosol [TASLink to PubMed article]
    Biological Process: trehalose catabolic process [TASLink to PubMed article]
    response to stress [TASLink to PubMed article]
    Molecular Function: alpha,alpha-trehalase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQVNTSQGP VAQGRQRRLS SLSEFNDPFS NAEVYYGPPT DPRKQKQAKP AKINRTRTMS  60
   61 VFDNVSPFKK TGFGKLQQTR RGSEDDTYSS SQGNRRFFIE DVDKTLNELL AAEDTDKNYQ 120
  121 ITIEDTGPKV LKVGTANSYG YKHINIRGTY MLSNLLQELT IAKSFGRHQI FLDEARINEN 180
  181 PVNRLSRLIN TQFWNSLTRR VDLNNVGEIA KDTKIDTPGA KNPRIYVPYD CPEQYEFYVQ 240
  241 ASQMHPSLKL EVEYLPKKIT AEYVKSVNDT PGLLALAMEE HFNPSTGEKT LIGYPYAVPG 300
  301 GRFNELYGWD SYMMALGLLE ANKTDVARGM VEHFIFEINH YGKILNANRS YYLCRSQPPF 360
  361 LTEMALVVFK KLGGRSNPDA VDLLKRAFQA SIKEYKTVWT ASPRLDPETG LSRYHPNGLG 420
  421 IPPETESDHF DTVLLPYASK HGVTLDEFKQ LYNDGKIKEP KLDEFFLHDR GVRESGHDTT 480
  481 YRFEGVCAYL ATIDLNSLLY KYEIDIADFI KEFCDDKYED PLDHSITTSA MWKEMAKIRQ 540
  541 EKITKYMWDD ESGFFFDYNT KIKHRTSYES ATTFWALWAG LATKEQAQKM VEKALPKLEM 600
  601 LGGLAACTER SRGPISISRP IRQWDYPFGW APHQILAWEG LRSYGYLTVT NRLAYRWLFM 660
  661 MTKAFVDYNG IVVEKYDVTR GTDPHRVEAE YGNQGADFKG AATEGFGWVN ASYILGLKYM 720
  721 NSHARRALGA CIPPISFFSS LRPQERNLYG L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BMH1 BMH2 NTH1
    View Details Krogan NJ, et al. (2006) ASK10 ATG1 BMH2 KIC1 NTH1 PIK1 REG1 RFX1 SOG2 UBP11 YDR348C YNR014W
    View Details Gavin AC, et al. (2006) BMH2 NTH1
    View Details Gavin AC, et al. (2002) BMH1 BMH2 NTH1 NTH2 PIK1 PSK1 RTG2
    View Details Ho Y, et al. (2002) ADR1 BMH1 BNR1 BOI2 CSR2 CYK3 GSY2 KCS1 NTH1 REG1 SOK1 STU1 SVL3 YFR017C YIL028W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RCY1 NTH1 1 Unpublished Fields Lab Data
    View Screen APC5 NTH1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NTH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..90] deduced N/A No confident structure predictions are available.
    2 View Details [91..751] Pfam 1000.0 Trehalase No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • trehalase activity
    		•  4.96737734681829 bayes_pls_golite062009
  • alpha,alpha-trehalase activity
    		•  4.67585600835702 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  2.41255243910528 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.15795475185128 bayes_pls_golite062009
  • hydrolase activity
    		•  1.51256018302478 bayes_pls_golite062009
  • catalytic activity
    		•  1.16285856935495 bayes_pls_golite062009
  • binding
    		•  0.82501412375097 bayes_pls_golite062009
  • glucan 1,4-alpha-glucosidase activity
    		•  0.681871542272872 bayes_pls_golite062009
  • protein binding
    		•  0.31260719357226 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle