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Protein Overview: HO

General Information:
Name(s) found: HO / YDL227C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 586 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    Biological Process: gene conversion at mating-type locus, DNA double-strand break formation [IDALink to PubMed article]
    mating type switching [IMPLink to PubMed article]
    gene conversion at mating-type locus [TASLink to PubMed article]
    Molecular Function: endonuclease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSENTTILM ANGEIKDIAN VTANSYVMCA DGSAARVINV TQGYQKIYNI QQKTKHRAFE  60
   61 GEPGRLDPRR RTVYQRLALQ CTAGHKLSVR VPTKPLLEKS GRNATKYKVR WRNLQQCQTL 120
  121 DGRIIIIPKN HHKTFPMTVE GEFAAKRFIE EMERSKGEYF NFDIEVRDLD YLDAQLRISS 180
  181 CIRFGPVLAG NGVLSKFLTG RSDLVTPAVK SMAWMLGLWL GDSTTKEPEI SVDSLDPKLM 240
  241 ESLRENAKIW GLYLTVCDDH VPLRAKHVRL HYGDGPDENR KTRNLRKNNP FWKAVTILKF 300
  301 KRDLDGEKQI PEFMYGEHIE VREAFLAGLI DSDGYVVKKG EGPESYKIAI QTVYSSIMDG 360
  361 IVHISRSLGM SATVTTRSAR EEIIEGRKVQ CQFTYDCNVA GGTTSQNVLS YCRSGHKTRE 420
  421 VPPIIKREPV YFSFTDDFQG ESTVYGLTIE GHKNFLLGNK IEVKSCRGCC VGEQLKISQK 480
  481 KNLKHCVACP RKGIKYFYKD WSGKNRVCAR CYGRYKFSGH HCINCKYVPE AREVKKAKDK 540
  541 GEKLGITPEG LPVKGPECIK CGGILQFDAV RGPHKSCGNN AGARIC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HO Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..56]
    [72..186]
    [429..471]    		 PSI-BLAST 634.221849 VMA1-derived endonuclease (VDE) PI-Scei intein; VMA1-derived endonuclease (VDE) PI-SceI
    2 View Details [57..71]
    [187..428]    		 PSI-BLAST 634.221849 VMA1-derived endonuclease (VDE) PI-Scei intein; VMA1-derived endonuclease (VDE) PI-SceI
    3 View Details [472..586] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • endonuclease activity
    		•  2.88774834271613 bayes_pls_golite062009
  • hydrolase activity
    		•  1.79906089282626 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.69943842528394 bayes_pls_golite062009
  • nuclease activity
    		•  1.69431538580197 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.67894659587491 bayes_pls_golite062009
  • binding
    		•  1.37674270036607 bayes_pls_golite062009
  • DNA binding
    		•  1.16190065301609 bayes_pls_golite062009
  • catalytic activity
    		•  1.00294942392567 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  2.74510263950241 bayes_pls_golite062009
  • DNA binding
    		•  2.44566855074341 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.43961252291181 bayes_pls_golite062009
  • binding
    		•  2.27558039325716 bayes_pls_golite062009
  • transcription factor activity
    		•  1.9022303099625 bayes_pls_golite062009
  • protein binding
    		•  1.32615100395362 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.911347670379084 bayes_pls_golite062009
  • transcription activator activity
    		•  0.879128871932985 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.839985608194026 bayes_pls_golite062009
  • transcription factor binding
    		•  0.68208034120073 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  0.469723986686757 bayes_pls_golite062009
  • catalytic activity
    		•  0.133319360419662 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle