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Protein Overview: IWR1

General Information:
Name(s) found: IWR1 / YDL115C [SGD]
Description(s) found:
Found 20 descriptions.
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  • Protein involved in transcription from polymerase II promoters; interacts with with most of the polymerase II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to the K1 killer toxin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 240 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    DNA-directed RNA polymerase II, holoenzyme [IPILink to PubMed article]
    Biological Process: transcription from RNA polymerase II promoter [ICLink to PubMed article][IGILink to PubMed article]
    meiosis [TASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNDYLKLNK GVEKTERKKP SRKYFTGDSA KIASLPSLDY VFDIYHLEKI HDDEVARYNN  60
   61 EKNIGFVKII EHIDLALDEE SDPNEARSDD EDSNDENYYQ NDYPEDEDDD RSILFGSEGE 120
  121 DIAALGEEIV IGVNKSRFSS WNDDKIQGSN GYHDVEEEYG DLFNRLGGKS DVLKSINSSN 180
  181 FIDLDGQEGE IEISDNEDDS DEGDDIEYPR NEFFPTDVDD PLAHHRDRIF HQLQKKINRS 240
  241

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DST1 IWR1 RPB10 RPB11 RPB2 RPB3 RPB4 RPB5 RPB7 RPB8 RPB9 RPO21 RPO26 SPT5 TAF14 TFG1 TFG2
    View Details Krogan NJ, et al. (2006) ALG3 BUD27 CBF2 DST1 ESS1 IWR1 RPB10 RPB11 RPB2 RPB3 RPB4 RPB5 RPB7 RPB8 RPB9 RPO21 RPO26 SPT4 TAF14 TFG1 TFG2 YBL059W YBR259W YPL225W
    View Details Gavin AC, et al. (2006) IWR1 RPB11 RPB2 RPB3 RPB4 RPB7 RPB9 TFG1 TFG2
    View Details Gavin AC, et al. (2002) ABD1 AOS1 IWR1 RPB11 RPB2 RPB3 RPB4 RPB5 RPB7 RPB8 RPB9 RPO21 RPO26 SPT4 SPT5 TAF14 TFG1 TFG2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..240] deduced N/A No confident structure predictions are available.
    2 View Details [167..240] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle