Protein Overview: ADH7

General Information:
Name(s) found:	ADH7 / YCR105W [SGD]
Description(s) found: SHOW ONLY BEST	pir\|\|S19417 alcohol dehydrogenase (NADP) (EC 1.1.1.2) homolog YCR105w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|6319949\|ref\|NP_010030.1\| NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; Adh7p [Saccharom [NCBI NR] gi\|1907243\|emb\|CAA42237.1\| hypothetical protein [Saccharomyces cerevisiae] [NCBI NR] gi\|140564\|sp\|P25377.1\|ADH7_YEAST RecName: Full=NADP-dependent alcohol dehydrogenase 7; AltName: Full=NADP-dependent alcohol dehydrogenase VII; Short=ADHVII [NCBI NR] (P25377) Hypothetical zinc-type alcohol dehydrogenase-like protein YCR105W (EC 1.1.1.-) [Swiss-Prot] NADP-dependent alcohol dehydrogenase 7 OS=Saccharomyces cerevisiae GN=ADH7 PE=1 SV=1 [Swiss-Prot] ADH7 NADP(H)-dependent alcohol dehydrogenase [mips] NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance [SGD] YCR105W, Chr III from 309063-310148 [yeast_orfs2] Chr III from 309063-310148 [yeastorf3.fasta] ADH7 SGDID:S0000702, Chr III from 309066-310151, Verified ORF [yeastflysequest.fasta] Adh7p [Saccharomyces cerevisiae]gi\|1907243\|emb\|CAA42237.1\| hypothetical protein [Saccharomyces cerevisiae]gi\|140564\|sp\|P25377\|YCZ5_YEAST Hypothetical zinc-type alcohol dehydrogenase-like protein YCR105Wgi\|83277\|pir\|\|S19417 alcohol dehydrogenase (NADP) [nrdb_11152004_Chlamydomonas] ADH7 SGDID:S000000702, Chr III from 309066-310151, Verified ORF, "NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity; may be involved in fusel alcohol synthesis" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ADH7 SGDID:S000000702, Chr III from 309067-310152, Verified ORF, "NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity; may be involved in fusel alcohol synthesis" [yeast-contam.fasta] ADH7 SGDID:S000000702, Chr III from 309067-310152, Verified ORF, "NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or i [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] NADP-dependent alcohol dehydrogenase 7 (NADP-dependent alcohol dehydrogenase VII) (ADHVII) [nr-271106-contam.fasta] hypothetical protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity; may be involved in fusel alcohol synthesis; Adh7p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ADH7 SGDID:S000000702, Chr III from 309067-310152, Verified ORF, "NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance" [yeast-bovrabprots.fasta] [chemostatdb.fasta] NADP-dependent alcohol dehydrogenase 7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADH7 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ADH7 SGDID:S000000702, Chr III from 309070-310155, Genome Release 64-1-1, Verified ORF, "NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance" [yeast-030211-contam.fasta] ADH7 SGDID:S000000702, Chr III from 309070-310155, Genome Release 64-2-1, Verified ORF, "NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance" [20141208_orf_trans.fasta] YCR105W SGDID:S000000702, Chr III from 309070-310155, Genome Release 64-1-1, Verified ORF, "NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	361 amino acids
Gene Ontology:
Cellular Component:	soluble fraction [IDA]
Biological Process:	alcohol metabolic process [IDA]
Molecular Function:	alcohol dehydrogenase (NADP+) activity [IDA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLYPEKFQGI GISNAKDWKH PKLVSFDPKP FGDHDVDVEI EACGICGSDF HIAVGNWGPV  60
   61 PENQILGHEI IGRVVKVGSK CHTGVKIGDR VGVGAQALAC FECERCKSDN EQYCTNDHVL 120
  121 TMWTPYKDGY ISQGGFASHV RLHEHFAIQI PENIPSPLAA PLLCGGITVF SPLLRNGCGP 180
  181 GKRVGIVGIG GIGHMGILLA KAMGAEVYAF SRGHSKREDS MKLGADHYIA MLEDKGWTEQ 240
  241 YSNALDLLVV CSSSLSKVNF DSIVKIMKIG GSIVSIAAPE VNEKLVLKPL GLMGVSISSS 300
  301 AIGSRKEIEQ LLKLVSEKNV KIWVEKLPIS EEGVSHAFTR MESGDVKYRF TLVDYDKKFH 360
  361 K

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ADH7 HCM1 OLA1 SNF8 VPS25 VPS36

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	APC5	ADH7	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..166] [304..361]	PSI-BLAST	217.9897	Alcohol dehydrogenase
2	View Details	[167..303]	PSI-BLAST	217.9897	Alcohol dehydrogenase

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
ethanol binding	3.52197234018599	bayes_pls_golite062009
NAD or NADH binding	3.39892156245282	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
methylglyoxal reductase (NADH-dependent) activity	3.00190838171391	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	2.94416173750168	bayes_pls_golite062009
retinol binding	2.90377414635828	bayes_pls_golite062009
hydroxymethylfurfural reductase (NADH) activity	2.2999175117758	bayes_pls_golite062009
hydroxymethylfurfural reductase activity	2.2999175117758	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	2.26153457113968	bayes_pls_golite062009
NADPH:quinone reductase activity	2.16668841986245	bayes_pls_golite062009
alcohol binding	2.01620480773869	bayes_pls_golite062009
all-trans retinal binding	1.96535395605564	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	1.81250968237368	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
DNA binding	1.61355789916908	bayes_pls_golite062009
transcription regulator activity	1.55390653047158	bayes_pls_golite062009
nucleic acid binding	1.48478425318425	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.22444609393125	bayes_pls_golite062009
chaperone binding	1.19079350615542	bayes_pls_golite062009
retinol dehydrogenase activity	1.16811519855038	bayes_pls_golite062009
binding	0.982999356179965	bayes_pls_golite062009
transcription factor activity	0.91090893050278	bayes_pls_golite062009
structural molecule activity	0.75267483298133	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.621273823467575	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.523513694229008	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	0.44080203587472	bayes_pls_golite062009
hydroxymethylfurfural reductase (NADPH) activity	0.382131941157781	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.216422278300306	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.169301675015808	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.162625185692811	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.0992243118937675	bayes_pls_golite062009
retinal binding	0.00342169427806049	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.43

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2