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Protein Overview: LEU2

General Information:
Name(s) found: LEU2 / YCL018W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 364 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDALink to PubMed article]
    Biological Process: leucine biosynthetic process [IMPLink to PubMed article]
    Molecular Function: 3-isopropylmalate dehydrogenase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAPKKIVVL PGDHVGQEIT AEAIKVLKAI SDVRSNVKFD FENHLIGGAA IDATGVPLPD  60
   61 EALEASKKAD AVLLGAVGGP KWGTGSVRPE QGLLKIRKEL QLYANLRPCN FASDSLLDLS 120
  121 PIKPQFAKGT DFVVVRELVG GIYFGKRKED DGDGVAWDSE QYTVPEVQRI TRMAAFMALQ 180
  181 HEPPLPIWSL DKANVLASSR LWRKTVEETI KNEFPTLKVQ HQLIDSAAMI LVKNPTHLNG 240
  241 IIITSNMFGD IISDEASVIP GSLGLLPSAS LASLPDKNTA FGLYEPCHGS APDLPKNKVN 300
  301 PIATILSAAM MLKLSLNLPE EGKAIEDAVK KVLDAGIRTG DLGGSNSTTE VGDAVAEEVK 360
  361 KILA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) LEU1 LEU2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BIM1 No Comments Cheeseman IM, et al. (2002)
    View Run MCM16 No Comments Cheeseman IM, et al. (2002)
    View Run STU1 No Comments Cheeseman IM, et al. (2002)
    View Run KIP3 No Comments Cheeseman IM, et al. (2002)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LEU2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..364] PSI-BLAST 954.54902 3-isopropylmalate dehydrogenase, IPMDH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • isocitrate dehydrogenase (NAD+) activity
    		•  5.9567768649084 bayes_pls_golite062009
  • isocitrate dehydrogenase activity
    		•  5.76817846591752 bayes_pls_golite062009
  • 3-isopropylmalate dehydrogenase activity
    		•  4.43187390953534 bayes_pls_golite062009
  • isocitrate dehydrogenase (NADP+) activity
    		•  3.47645456015586 bayes_pls_golite062009
  • malate dehydrogenase activity
    		•  3.17013707624362 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.74237430402883 bayes_pls_golite062009
  • catalytic activity
    		•  2.71251959637136 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.46799258909805 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  2.38235863668553 bayes_pls_golite062009
  • binding
    		•  0.768867938429375 bayes_pls_golite062009
  • malic enzyme activity
    		•  0.483776792839856 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.466038297142601 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle