Protein Overview: FTH1

General Information:
Name(s) found:	FTH1 / YBR207W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6319684\|ref\|NP_009766.1\| Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; Fth1p [Saccharomyces cerev [NCBI NR] gi\|586330\|sp\|P38310.1\|FTH1_YEAST RecName: Full=Iron transporter FTH1 [NCBI NR] gi\|536586\|emb\|CAA85171.1\| FTH1 [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S34929 probable membrane protein YBR207w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|311683\|emb\|CAA79694.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] Iron transporter FTH1 OS=Saccharomyces cerevisiae GN=FTH1 PE=1 SV=1 [Swiss-Prot] FTH1 Putative high affinity iron transporter involved in transport of intravacuolar stores of iron [mips] Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis [SGD] FTH1, Chr II from 635104-636501 [yeast_orfs2] Chr II from 635104-636501 [yeastorf3.fasta] Chr II from 635103-636500 [yeastorf4.fasta] Chr II from 635101-636498 [yeastorf5.fasta] (P38310) Hypothetical 51.5 kDa protein in KTR3-DUR1,2 intergenic region [4932.FASTACCERV.txt] FTH1 SGDID:S0000411, Chr II from 635103-636500, Verified ORF [yeastflysequest.fasta] FTH1 SGDID:S0000411, Chr II from 635141-636538, Verified ORF [10112005cervSGD.fasta] Fth1p [Saccharomyces cerevisiae]gi\|311683\|emb\|CAA79694.1\| unknown [Saccharomyces cerevisiae]gi\|536586\|emb\|CAA85171.1\| FTH1 [Saccharomyces cerevisiae]gi\|486699\|pir\|\|S34929 probable membrane protein YBR207w - yeast (Saccharomyces cerevisiae)gi\|586330\|sp [nrdb_11152004_Chlamydomonas] (P38310) Iron transporter FTH1 [cerv4932.FASTAC] FTH1 SGDID:S000000411, Chr II from 635141-636538, Verified ORF, "Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in en [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] FTH1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; Fth1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Iron transporter FTH1 [nr-271106-contam.fasta] FTH1 SGDID:S000000411, Chr II from 635141-636538, Verified ORF, "Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis" [yeast-bovrabprots.fasta] [chemostatdb.fasta]
Organism:	Saccharomyces cerevisiae
Length:	465 amino acids
Gene Ontology:
Cellular Component:	fungal-type vacuole membrane [IDA ]
Biological Process:	high-affinity iron ion transport [IPI] endocytosis [IMP]
Molecular Function:	iron ion transmembrane transporter activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFEDYFSFQ IFFIFLRKSL EIVVIVSILL TIVKQDLSVE DDSPFEGSSS SAGLPSPNTN  60
   61 TNADSTTAFL QAGPSDGNAI GTSATAANNK SRPLNVEEEE EIYEYSNELR DQDRESDEHT 120
  121 ADNVKLYQKL KIQILAGGAF GLLLCMLIGG AFVSIFYHIG TDLWTLSEHY YEGVLSLVAS 180
  181 VIISVMGLFF LRMGKLREKF RVKLASIIYS KDNNLLGNKT QKGVKFSQKY SFFILPFITT 240
  241 LREGLEAVYS IGGIGIDQPL SSIPLSMVLA TAISTVFGIF FFRYSSSLSL KICLVVATCF 300
  301 LYLIAAGLFS KGVWQLELQD YVNKCNGQDM SEVENGPGSY DISRSVWHVN CCNGEKDGGW 360
  361 MIFTAIFGWT NSATVGSVIS YNAYWLVLKY ALKLLMIEGK CGYIPYLPIS WQKKRIMKRL 420
  421 SIAKASLDLK HHTSELNSST SEPDSQRRSK DSSVPLIIDS SGSAN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Gavin AC, et al. (2002)		ADH1 FET5 FKS1 FTH1 GEA2 KAP123 RPN3
View Details	Qiu et al. (2008)		BPT1 COT1 FET3 FTH1 PMC1 ZRT3

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	LIA1	FTH1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	FTH1	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..465]	Pfam	182.481486	Iron permease FTR1 family No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2