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Protein Overview: TFC1

General Information:
Name(s) found: TFC1 / YBR123C [SGD]
Description(s) found:
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  • gi|6319600|ref|NP_009681.1| One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TF [NCBI NR]
  • gi|536406|emb|CAA85080.1| TFC1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|476077|emb|CAA55625.1| transciption factor TFIIIC [Saccharomyces cerevisiae] [NCBI NR]
  • gi|417930|sp|P32367.1|TFC1_YEAST RecName: Full=Transcription factor tau 95 kDa subunit; AltName: Full=TFIIIC 95 kDa subunit; AltName: Full=Transcription factor C subunit 1 [NCBI NR]
  • gi|172891|gb|AAA35144.1| transcription factor [Saccharomyces cerevisiae] [NCBI NR]
  • gi|172887|gb|AAA35142.1| transcription factor IIIC 95 kDa subunit [Saccharomyces cerevisiae] [NCBI NR]
  • pir||A39711 transcription factor IIIC 95K chain - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Transcription factor tau 95 kDa subunit OS=Saccharomyces cerevisiae GN=TFC1 PE=1 SV=1 [Swiss-Prot]
  • TFC1 TFIIIC (transcription initiation factor) subunit, 95 kD [mips]
  • One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63 [SGD]
  • TFC1, Chr II from 484700-486649, reverse complement [yeast_orfs2]
  • Chr II from 484700-486649, reverse complement [yeastorf3.fasta]
  • Chr II from 484699-486648, reverse complement [yeastorf4.fasta]
  • Chr II from 486646-484697, reverse complement [yeastorf5.fasta]
  • (P32367) Transcription factor tau 95 kDa subunit (TFIIIC 95 kDa subunit) [4932.FASTACCERV.txt]
  • TFC1 SGDID:S0000327, Chr II from 486647-484698, reverse complement, Verified ORF [yeastflysequest.fasta]
  • TFC1 SGDID:S0000327, Chr II from 486685-484736, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Tfc1p [Saccharomyces cerevisiae]gi|476077|emb|CAA55625.1| transciption factor TFIIIC [Saccharomyces cerevisiae]gi|536406|emb|CAA85080.1| TFC1 [Saccharomyces cerevisiae]gi|417930|sp|P32367|TFC1_YEAST Transcription factor tau 95 kDa subunit (TFIIIC 95 kD [nrdb_11152004_Chlamydomonas]
  • TFC1 SGDID:S000000327, Chr II from 486685-484736, reverse complement, Verified ORF, "One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA prom [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • transcription factor IIIC 95 kDa subunit [nr-271106-contam.fasta]
  • Transcription factor tau 95 kDa subunit (TFIIIC 95 kDa subunit) [nr-271106-contam.fasta]
  • TFC1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • transciption factor TFIIIC [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • transcription factor [nr-271106-contam.fasta]
  • One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63; Tfc1p [Saccharomyce [nr-271106-contam.fasta]
  • TFC1 SGDID:S000000327, Chr II from 486685-484736, reverse complement, Verified ORF, "One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Transcription factor tau 95 kDa subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TFC1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TFC1 SGDID:S000000327, Chr II from 486691-484742, Genome Release 64-1-1, reverse complement, Verified ORF, "One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63" [yeast-030211-contam.fasta]
  • TFC1 SGDID:S000000327, Chr II from 486691-484742, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63" [20141208_orf_trans.fasta]
  • TR3950|c0_g1_i1|g.2805 ORF TR3950|c0_g1_i1|g.2805 TR3950|c0_g1_i1|m.2805 type:complete len:650 (+) TR3950|c0_g1_i1:170-2119(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • YBR123C SGDID:S000000327, Chr II from 486691-484742, Genome Release 64-1-1, reverse complement, Verified ORF, "One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_5065|g.2984 ORF ID=asmbl_5065|g.2984 ID=asmbl_5065|m.2984 type:complete len:650 (+) ID=asmbl_5065:170-2119(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 649 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIIIC complex [TASLink to PubMed article]
    Biological Process: transcription initiation from RNA polymerase III promoter [TASLink to PubMed article]
    Molecular Function: RNA polymerase III transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVEEPLATL SSIPDSSADQ APPLIADEFT LDLPRIPSLE LPLNVSTKHS SIQKAIKMCG  60
   61 GIEKVKEAFK EHGPIESQHG LQLYLNDDTD SDGSKSYFNE HPVIGKRVPF RDESVILKVT 120
  121 MPKGTLSKNN NSVKDSIKSL KDSNKLRVTP VSIVDNTIKF REMSDFQIKL DNVPSAREFK 180
  181 SSFGSLEWNN FKSFVNSVPD NDSQPQENIG NLILDRSVKI PSTDFQLPPP PKLSMVGFPL 240
  241 LYKYKANPFA KKKKNGVTEV KGTYIKNYQL FVHDLSDKTV IPSQAHEQVL YDFEVAKKTK 300
  301 VYPGTKSDSK FYESLEECLK ILRELFARRP IWVKRHLDGI VPKKIHHTMK IALALISYRF 360
  361 TMGPWRNTYI KFGIDPRSSV EYAQYQTEYF KIERKLLSSP IVKKNVPKPP PLVFESDTPG 420
  421 GIDSRFKFDG KRIPWYLMLQ IDLLIGEPNI AEVFHNVEYL DKANELTGWF KELDLVKIRR 480
  481 IVKYELGCMV QGNYEYNKYK LKYFKTMLFV KESMVPENKN SEEGMGVNTN KDADGDINMD 540
  541 AGSQMSSNAI EEDKGIAAGD DFDDNGAITE EPDDAALENE EMDTDQNLKV PASIDDDVDD 600
  601 VDADEEEQES FDVKTASFQD IINKIAKLDP KTAETMKSEL KGFVDEVDL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details (MIPS) Mewes HW, et al. (2004) TFC1 TFC3 TFC4 TFC6 TFC7
    View Details Krogan NJ, et al. (2006) TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details Gavin AC, et al. (2006) TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details Gavin AC, et al. (2002) ITC1 TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details Qiu et al. (2008) BDP1 BRF1 PZF1 TFB5 TFC1 TFC3 TFC4 TFC6 TFC7 TFC8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TFC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..540] MSA 3.016913 View MSA. No confident structure predictions are available.
    2 View Details [541..649] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle