Protein Overview: BDH2

General Information:
Name(s) found:	BDH2 / YAL061W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731294\|sp\|P39713.1\|BDH2_YEAST RecName: Full=Probable (R,R)-butanediol dehydrogenase 2 [NCBI NR] gi\|6319257\|ref\|NP_009340.1\| Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene; Bdh2p [Saccharomyces cerevisiae] [NCBI NR] gi\|595525\|gb\|AAC04973.1\| Yal061wp [Saccharomyces cerevisiae] [NCBI NR] gi\|51012911\|gb\|AAT92749.1\| YAL061W [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S51961 FUN50 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] Zinc-type alcohol dehydrogenase-like protein YAL061W OS=Saccharomyces cerevisiae GN=YAL061W PE=1 SV=1 [Swiss-Prot] Probable (R,R)-butanediol dehydrogenase 2 OS=Saccharomyces cerevisiae GN=BDH2 PE=1 SV=1 [Swiss-Prot] Putative polyol dehydrogenase [mips] Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3 [SGD] YAL061W, Chr I from 33449-34702 [yeast_orfs2] Chr I from 33449-34702 [yeastorf3.fasta] (P39713) Hypothetical zinc-type alcohol dehydrogenase-like protein in GDH3-CNE1 intergenic region [4932.FASTACCERV.txt] YAL061W SGDID:S0000057, Chr I from 33449-34702, Uncharacterized ORF [yeastflysequest.fasta] Yal061wp [Saccharomyces cerevisiae]gi\|51012911\|gb\|AAT92749.1\| YAL061W [Saccharomyces cerevisiae]gi\|731294\|sp\|P39713\|YAG1_YEAST Hypothetical zinc-type alcohol dehydrogenase-like protein in GDH3-CNE1 intergenic regiongi\|595525\|gb\|AAC04973.1\| Yal061wp [Sa [nrdb_11152004_Chlamydomonas] YAL061W SGDID:S000000057, Chr I from 33449-34702, Uncharacterized ORF, "putative polyol dehydrogenase" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] BDH2 SGDID:S000000057, Chr I from 33449-34702, Uncharacterized ORF, "Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Yal061wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Zinc-type alcohol dehydrogenase-like protein YAL061W [nr-271106-contam.fasta] YAL061W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] putative polyol dehydrogenase; Yal061wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] BDH2 SGDID:S000000057, Chr I from 33449-34702, Uncharacterized ORF, "Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] [chemostatdb.fasta] Probable diacetyl reductase [(R)-acetoin forming] 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BDH2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] BDH2 SGDID:S000000057, Chr I from 33448-34701, Genome Release 64-1-1, Uncharacterized ORF, "Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3" [yeast-030211-contam.fasta] BDH2 SGDID:S000000057, Chr I from 33448-34701, Genome Release 64-2-1, Uncharacterized ORF, "Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3" [20141208_orf_trans.fasta] YAL061W SGDID:S000000057, Chr I from 33448-34701, Genome Release 64-1-1, Uncharacterized ORF, "Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	417 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	biological_process [ND]
Molecular Function:	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [ISS ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRALAYFGKG NIRFTNHLKE PHIVAPDELV IDIEWCGICG TDLHEYTDGP IFFPEDGHTH  60
   61 EISHNPLPQA MGHEMAGTVL EVGPGVKNLK VGDKVVVEPT GTCRDRYRWP LSPNVDKEWC 120
  121 AACKKGYYNI CSYLGLCGAG VQSGGFAERV VMNESHCYKV PDFVPLDVAA LIQPLAVCWH 180
  181 AIRVCEFKAG STALIIGAGP IGLGTILALN AAGCKDIVVS EPAKVRRELA EKMGARVYDP 240
  241 TAHAAKESID YLRSIADGGD GFDYTFDCSG LEVTLNAAIQ CLTFRGTAVN LAMWGHHKIQ 300
  301 FSPMDITLHE RKYTGSMCYT HHDFEAVIEA LEEGRIDIDR ARHMITGRVN IEDGLDGAIM 360
  361 KLINEKESTI KIILTPNNHG ELNREADNEK KEISELSSRK DQERLRESIN EAKLRHT

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		BDH1 BDH2
View Details	Krogan NJ, et al. (2006)		BDH1 BDH2
View Details	Gavin AC, et al. (2002)		BDH2 PSE1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ARF3	BDH2	2	Unpublished Fields Lab Data
View Screen	PRP40	BDH2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	BDH2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..173] [344..417]	PSI-BLAST	463.24799	Ketose reductase (sorbitol dehydrogenase)
2	View Details	[174..343]	PSI-BLAST	463.24799	Ketose reductase (sorbitol dehydrogenase)

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
L-iditol 2-dehydrogenase activity	3.00103406168296	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	2.94416173750168	bayes_pls_golite062009
chaperone binding	2.79912653573494	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	2.26153457113968	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity	0.9367410227151	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.418775403210681	bayes_pls_golite062009
NAD or NADH binding	0.39817482511246	bayes_pls_golite062009
L-arabinitol 2-dehydrogenase activity	0.382131941157781	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	0.36426941921419	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	0.361275519814065	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.32207755075663	bayes_pls_golite062009
binding	0.311888962066118	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase activity	0.298691872199351	bayes_pls_golite062009
ATPase activity	0.275256680720412	bayes_pls_golite062009
nucleic acid binding	0.179327587154303	bayes_pls_golite062009
DNA binding	0.0742540086107448	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.78

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2