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Protein Overview: LTE1

General Information:
Name(s) found: LTE1 / YAL024C [SGD]
Description(s) found:
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  • gi|6319295|ref|NP_009378.1| Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP; Lte1p [NCBI NR]
  • gi|595562|gb|AAC05008.1| Lte1p: GDP/GTP exchange factor required for growth at low temperatures [Saccharomyces cerevisiae] [NCBI NR]
  • gi|585430|sp|P07866.2|LTE1_YEAST RecName: Full=Guanine nucleotide exchange factor LTE1; AltName: Full=Low temperature essential protein 1 [NCBI NR]
  • gi|437023|gb|AAA50468.1| putative [Saccharomyces cerevisiae] [NCBI NR]
  • pir||BVBYL1 guanine nucleotide-releasing factor LTE1 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Guanine nucleotide exchange factor LTE1 OS=Saccharomyces cerevisiae GN=LTE1 PE=1 SV=2 [Swiss-Prot]
  • LTE1 GDP/GTP exchange factor [mips]
  • Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures [SGD]
  • LTE1, Chr I from 101567-105874, reverse complement [yeast_orfs2]
  • Chr I from 101567-105874, reverse complement [yeastorf3.fasta]
  • Chr I from 105874-101567, reverse complement [yeastorf5.fasta]
  • (P07866) Low temperature essential protein [4932.FASTACCERV.txt]
  • LTE1 SGDID:S0000022, Chr I from 105875-101568, reverse complement, Verified ORF [yeastflysequest.fasta]
  • LTE1 SGDID:S0000022, Chr I from 105873-101566, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Lte1p [Saccharomyces cerevisiae]gi|585430|sp|P07866|LTE1_YEAST Low temperature essential proteingi|2144608|pir||BVBYL1 guanine nucleotide-releasing factor LTE1 - yeast (Saccharomyces cerevisiae)gi|595562|gb|AAC05008.1| Lte1p: GDP/GTP exchange factor r [nrdb_11152004_Chlamydomonas]
  • LTE1 SGDID:S000000022, Chr I from 105873-101566, reverse complement, Verified ORF, "Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of m [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • putative [nr-271106-contam.fasta]
  • Low temperature essential protein [nr-271106-contam.fasta]
  • Lte1p: GDP/GTP exchange factor required for growth at low temperatures [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP; Lte1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • LTE1 SGDID:S000000022, Chr I from 105873-101566, reverse complement, Verified ORF, "Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • LTE1 SGDID:S000000022, Chr I from 105873-101566, reverse complement, Verified ORF, "Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • LTE1 SGDID:S000000022, Chr I from 105873-101566, reverse complement, Verified ORF, "Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures" [SGDyeast.20101221.fasta]
  • Guanine nucleotide exchange factor LTE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LTE1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • LTE1 SGDID:S000000022, Chr I from 105872-101565, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures" [yeast-030211-contam.fasta]
  • LTE1 SGDID:S000000022, Chr I from 105872-101565, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein similar to GDP/GTP exchange factors; without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures" [20141208_orf_trans.fasta]
  • YAL024C SGDID:S000000022, Chr I from 105872-101565, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1435 amino acids

    Gene Ontology:
    Cellular Component: cellular bud [TASLink to PubMed article]
    Biological Process: vesicle-mediated transport [IGILink to PubMed article]
    regulation of exit from mitosis [TASLink to PubMed articleLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    mitotic cell cycle spindle orientation checkpoint [TASLink to PubMed article]
    Molecular Function: guanyl-nucleotide exchange factor activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIFSQKDYY PTPSSNVISY ESDCVSKPVN SADLPALIVH LSSPLEGVDY NASADFFLIY  60
   61 RNFITPQDLH DLLIYRFRWC IREITTNAAK AKRRRIGEVA LVRTFVLLRH SILNYFVQDF 120
  121 LPNITLRLRL IEFLNDKHIE QYPKIISSCI INLKKNWVHC SKLVWENIEL NEPDKLDFDA 180
  181 WLHYSLKDFT QLESLHKRGS RLSIYARQSF ASPDFRNQSV LSLYKTSDVF RLPEKLQSSN 240
  241 SSKNQRSPSM LLFPDNTSNV YSKHRIAKEP SVDNESEDMS DSKQKISHLS KVTLVSTLMK 300
  301 GVDYPSSYAV DKIMPPTPAK KVEFILNSLY IPEDLNEQSG TLQGTSTTSS LDNNSNSNSR 360
  361 SNTSSMSVLH RSAIGLLAKW MKNHNRHDSS NDKKFMSAIK PANQKPEMDA FVKYVVSISS 420
  421 LNRKSSKEEE EEFLNSDSSK FDILSARTID EVESLLHLQN QLIEKVQTHS NNNRGPTVNV 480
  481 DCERREHIHD IKILQQNSFK PSNDNFSAMD NLDLYQTVSS IAQSVISLTN TLNKQLQNNE 540
  541 SNMQPSPSYD ALQRRKVKSL TTAYYNKMHG SYSAESMRLF DKDNSSSRTD ENGPQRLLFH 600
  601 ETDKTNSEAI TNMTPRRKNH SQSQKSMTSS PLKNVLPDLK ESSPLNDSRE DTESITYSYD 660
  661 SELSSSSPPR DTVTKKSRKV RNIVNNTDSP TLKTKTGFLN LREFTFEDTK SLDEKKSTID 720
  721 GLEKNYDNKE NQESEYESTK KLDNSLDASS EANNYDITTR KKHSSCNHKI KQAVVRPASG 780
  781 RISISRVQSI AITPTKELSI VDPEQNKSNS VIEEISEIEP LNLEYNKKSA LYSDTSSTVI 840
  841 SISTSKLFES AQNSPLKQTQ NPQREFPNGT SVSETNRIRL SIAPTIESVV SDLNSITTGS 900
  901 TVETFETSRD LPVPHQRIIN LREEYQRGNQ DIISNTSSLH ELKTIDLSDS NNDLESPSTH 960
  961 AKNNKYFFSP DDGSIDVASP MKNVEELKSK FLKNESETNS NISGSVLTMD DIDINDTSSA1020
 1021 RNTRRANSES AFTGSLNKKN LNEIANMLDD SINDDPITVA LMKLEGTYEK IPEKPENTKS1080
 1081 SDAIGIKTSK LADEVEMLNL NNLPSFQNSP AEKRKSLLIE RRRQTIMNIP FTPDQSEKEG1140
 1141 FTSSSPEKID VSANVDVAVQ AAQIQELIGQ YRIHDSRLMI SNNESHVPFI LMYDSLSVAQ1200
 1201 QMTLIEKEIL GEIDWKDLLD LKMKHEGPQV ISWLQLLVRN ETLSGIDLAI SRFNLTVDWI1260
 1261 ISEILLTKSS KMKRNVIQRF IHVADHCRTF QNFNTLMEII LALSSSVVQK FTDAWRLIEP1320
 1321 GDLLTWEELK KIPSLDRNYS TIRNLLNSVN PLVGCVPFIV VYLSDLSANA EKKDWILEDK1380
 1381 VVNYNKFDTN VQIVKNFIQR VQWSKFYTFK VNHELLSKCV YISTLTQEEI NELST

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) LTE1 RPS3
    View Details Krogan NJ, et al. (2006) AI1 LTE1 TAZ1
    View Details Gavin AC, et al. (2006) BEM2 KEL1 LTE1
    View Details Gavin AC, et al. (2002) BLM10 CDC55 CIN1 ERG13 GUS1 HHF1, HHF2 HOS2 HOS4 IML1 KAP95 KEL1 LTE1 MYO5 PFK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RRD2 RTS1 RTS3 SCL1 SET3 SIF2 SNT1 SRP1 TDH2 TDH3 TEF4 TPD3 YBL104C YOR1 YRA1 ZDS1 ZDS2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data LTE1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..121] Pfam 23.154902 Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif No confident structure predictions are available.
    2 View Details [122..963] deduced N/A No confident structure predictions are available.
    3 View Details [964..1090] MSA 1.012983 View MSA. No confident structure predictions are available.
    4 View Details [1091..1161] deduced N/A No confident structure predictions are available.
    5 View Details [1162..1435] PSI-BLAST 109.457575 Son of sevenless protein homolog 1 (sos-1)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle