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View Structure Prediction Details

Protein: LTE1
Organism: Saccharomyces cerevisiae
Length: 1435 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LTE1.

Description E-value Query
Range
Subject
Range
LTE1_YEAST - Guanine nucleotide exchange factor LTE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
gi|190406672 - gi|190406672|gb|EDV09939.1| low temperature essential protein [Saccharomyces cerevisiae RM11-1a]
LTE1 - Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymme...
0.0 [1..1435] [1..1435]
RGRF1_MOUSE - Ras-specific guanine nucleotide-releasing factor 1 OS=Mus musculus GN=Rasgrf1 PE=1 SV=2
0.0 [989..1434] [823..1253]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [989..1434] [821..1251]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
0.0 [989..1434] [812..1235]
gi|57665 - gi|57665|emb|CAA47666.1| P140 RAS-GRF [Rattus rattus]
RGRF1_RAT - Ras-specific guanine nucleotide-releasing factor 1 OS=Rattus norvegicus GN=Rasgrf1 PE=1 SV=1
0.0 [989..1434] [812..1235]

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Predicted Domain #1
Region A:
Residues: [1-121]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIFSQKDYY PTPSSNVISY ESDCVSKPVN SADLPALIVH LSSPLEGVDY NASADFFLIY  60
   61 RNFITPQDLH DLLIYRFRWC IREITTNAAK AKRRRIGEVA LVRTFVLLRH SILNYFVQDF 120
  121 L

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 23.154902
Match: PF00618
Description: Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [122-963]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNITLRLRLI EFLNDKHIEQ YPKIISSCII NLKKNWVHCS KLVWENIELN EPDKLDFDAW  60
   61 LHYSLKDFTQ LESLHKRGSR LSIYARQSFA SPDFRNQSVL SLYKTSDVFR LPEKLQSSNS 120
  121 SKNQRSPSML LFPDNTSNVY SKHRIAKEPS VDNESEDMSD SKQKISHLSK VTLVSTLMKG 180
  181 VDYPSSYAVD KIMPPTPAKK VEFILNSLYI PEDLNEQSGT LQGTSTTSSL DNNSNSNSRS 240
  241 NTSSMSVLHR SAIGLLAKWM KNHNRHDSSN DKKFMSAIKP ANQKPEMDAF VKYVVSISSL 300
  301 NRKSSKEEEE EFLNSDSSKF DILSARTIDE VESLLHLQNQ LIEKVQTHSN NNRGPTVNVD 360
  361 CERREHIHDI KILQQNSFKP SNDNFSAMDN LDLYQTVSSI AQSVISLTNT LNKQLQNNES 420
  421 NMQPSPSYDA LQRRKVKSLT TAYYNKMHGS YSAESMRLFD KDNSSSRTDE NGPQRLLFHE 480
  481 TDKTNSEAIT NMTPRRKNHS QSQKSMTSSP LKNVLPDLKE SSPLNDSRED TESITYSYDS 540
  541 ELSSSSPPRD TVTKKSRKVR NIVNNTDSPT LKTKTGFLNL REFTFEDTKS LDEKKSTIDG 600
  601 LEKNYDNKEN QESEYESTKK LDNSLDASSE ANNYDITTRK KHSSCNHKIK QAVVRPASGR 660
  661 ISISRVQSIA ITPTKELSIV DPEQNKSNSV IEEISEIEPL NLEYNKKSAL YSDTSSTVIS 720
  721 ISTSKLFESA QNSPLKQTQN PQREFPNGTS VSETNRIRLS IAPTIESVVS DLNSITTGST 780
  781 VETFETSRDL PVPHQRIINL REEYQRGNQD IISNTSSLHE LKTIDLSDSN NDLESPSTHA 840
  841 KN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [964-1090]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKYFFSPDDG SIDVASPMKN VEELKSKFLK NESETNSNIS GSVLTMDDID INDTSSARNT  60
   61 RRANSESAFT GSLNKKNLNE IANMLDDSIN DDPITVALMK LEGTYEKIPE KPENTKSSDA 120
  121 IGIKTSK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [1091-1161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LADEVEMLNL NNLPSFQNSP AEKRKSLLIE RRRQTIMNIP FTPDQSEKEG FTSSSPEKID  60
   61 VSANVDVAVQ A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1162-1435]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQIQELIGQY RIHDSRLMIS NNESHVPFIL MYDSLSVAQQ MTLIEKEILG EIDWKDLLDL  60
   61 KMKHEGPQVI SWLQLLVRNE TLSGIDLAIS RFNLTVDWII SEILLTKSSK MKRNVIQRFI 120
  121 HVADHCRTFQ NFNTLMEIIL ALSSSVVQKF TDAWRLIEPG DLLTWEELKK IPSLDRNYST 180
  181 IRNLLNSVNP LVGCVPFIVV YLSDLSANAE KKDWILEDKV VNYNKFDTNV QIVKNFIQRV 240
  241 QWSKFYTFKV NHELLSKCVY ISTLTQEEIN ELST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 109.457575
Match: 1bkdS_
Description: Son of sevenless protein homolog 1 (sos-1)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle